Metástase, uma visão atualizada

Autores

  • Fernando A. B. Pitrez Oncologista da Santa Casa de Misericórdia de Porto Alegre/Hospital Santa Rita. Porto Alegre (RS), Brasil
  • Hélio F. Lemchem Oncologista da Santa Casa de Misericórdia de Porto Alegre/Hospital Santa Rita. Porto Alegre (RS), Brasil
  • Rogério Grossmann Oncologista da Santa Casa de Misericórdia de Porto Alegre/Hospital Santa Rita. Porto Alegre (RS), Brasil
  • José Pio Furtado Oncologista da Santa Casa de Misericórdia de Porto Alegre/Hospital Santa Rita. Porto Alegre (RS), Brasil
  • Richard Borba Magalhães Fundação Faculdade Federal de Ciências Médicas de Porto Alegre (FFFCMPA). Porto Alegre (RS), Brasil
  • Reginaldo Castilho Fundação Faculdade Federal de Ciências Médicas de Porto Alegre (FFFCMPA). Porto Alegre (RS), Brasil

DOI:

https://doi.org/10.32635/2176-9745.RBC.1995v41n2.2931

Palavras-chave:

Metástases, Cascata Metastática

Resumo

Os autores revisam a Cascata Metastática, nome que designa a seqüência de fenômenos que levam à implantação da célula metastática e sua multiplicação no órgão alvo. Através de uma revisão atualizada da literatura pertinente, expõem as múltiplas teorias e experimentos que tentam esclarecer os complexos mecanismos bioquímicos e enzimáticos que envolvem este fascinante processo, bem como sua implicação terapêutica.

Downloads

Não há dados estatísticos.

Referências

DUDJAK, L.A. - Cancer Metastasis. Semin Oncol Nurs, 8(1):40-50, 1992. DOI: https://doi.org/10.1016/0749-2081(92)90007-P

KUPEHELLA, C.E. - The spread of cancer: invasion and metastasis. Dimension of cancer. Belmont CA, Wadsworth, 1987.

EVANS, C.W. - Celi adhesion and metastasis. Cell Biol Int Rep, 16(1):1-10, 1992. DOI: https://doi.org/10.1016/S0309-1651(06)80150-5

LIOTTA, L.A. - Tumor invasion and metastasis – role of the extracellular matrix. Rhoads Memorial Award Lecture. Cancer Res, 46:1-7, 1986.

NAKAJIMA, M.; CHOP, A.M. - Tumor invasion and extraceilular matrix enzymes: regulation of activity by organ factors. Semin Cancer Biol, 2(2):1 15-27, 1991.

CAJOT, J.F.; SORDAT, B.; BACHMAN, E – Human primary colon carcinoma xenografted into nude mice. ll. Modulation of tumor plasminogen activator activity by the host tissue enviroriment. J Nati Cancer Inst, 77:1099-107, 1986. DOI: https://doi.org/10.1093/jnci/77.3.703

KHOKHA, R.; DENHARDT, D.T. - Matrix metalloproteinases and tissue inhibitor of metalloproteinases: a review of their role in tumorigenesis and tissue invasion. Invasion Metastasis, 9291-405, 1989.

BLASI, E; VERDE, P. - Urokinase-dependent ceil surface proteoiysis and cancer. Semin Cancer Biol, 1:117-26, 1990.

KANEMOTO, T et al. - Identification of an aminoacid sequence from the laminin Achain that stimulates metastasis and coliagenase IV production. Proc Nati Acad Sci USA, 87:2279-83, 1990. DOI: https://doi.org/10.1073/pnas.87.6.2279

POURREAU-SCHNEIDER, N. et al. - Modulation of plasminogem activator systems by matrix componentes in two breast cancer celi lines: MCF-7 and MDA-M13-231. J Nati Cancer Inst, 81.259-266, 1989. DOI: https://doi.org/10.1093/jnci/81.4.259

STRACKE, M.L. et al. - Celi motility, principal requirement for metastasis. Experientia Suppl, 59:147-62, 1991. DOI: https://doi.org/10.1007/978-3-0348-7494-6_10

FOLKMAN, I. - How is blood vessel growth regulated in normal and neoplastic tissue? Cancer Res, 46:467-73, 1986.

FOLKMAN, I.; KLAGSBRUM, M. -Angiogenic Factors. Science, 235:442-7, 1987. DOI: https://doi.org/10.1126/science.2432664

FIDLER, I.J.; BALCH, C.M. - The biology of cancer metastasis and impiication for therapy. Curr Probi Surg, 24:137-209, 1987. DOI: https://doi.org/10.1016/0011-3840(87)90002-5

POSTE, G.; FIDLER, I.J. -lhe pathogenesis of cancer metastasis. Nature, 283:139-46, 1980. DOI: https://doi.org/10.1038/283139a0

BRODLAND, D.G. et al. - Mechanisms of metastasis. J Am Acad Dermatol, 27(1):1 -8, 1992. DOI: https://doi.org/10.1016/0190-9622(92)70146-7

MCCARTHY, J.B.; SKUBITZ, A.P.N.; PALM, S.L. et al. - Metastasis inhibition of different tumor types by purified iaminin fragments and a heparin-binding fragment of fibronectin. J Nati Cancer Inst, 80:108-16, 1988. DOI: https://doi.org/10.1093/jnci/80.2.108

ZETTER, B.R. -The cellular basis of site-specific tumor metastasis. N Engi J Med, 332:605-12, 1990. DOI: https://doi.org/10.1056/NEJM199003013220907

LIOTTA, L.A.; KOHN, E. - Cancer invasion and metastasis. JAMA, 263:1123-6, 1990. DOI: https://doi.org/10.1001/jama.263.8.1123

PAGET, S. - Distribution of secondary growths in cancer of the breast. Lancet, 1:571-3, 1889. DOI: https://doi.org/10.1016/S0140-6736(00)49915-0

JOHNSON, R.C. et al. - Endothelial cell membrane vesicies in the study of organ preference of metastasis. Cancer Res, 51.294-9, 1991.

BERG, E.L. et al. - Homing receptors and vascular adressins: cell adhesion molecuies that direct lymphocyte traffic. ImmunoI Rev, 108.5-18, 1989. DOI: https://doi.org/10.1111/j.1600-065X.1989.tb00010.x

AlCE, G.E.; BEVILACQUA, M.P. - An inducible endothelial cell surface glycoprotein mediates melanoma adhesion. Science, 246:1303-6, 1989. DOI: https://doi.org/10.1126/science.2588007

GUNTHERT, U. et al. - A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell, 65:13-24, 1991. DOI: https://doi.org/10.1016/0092-8674(91)90403-L

N1COLS, G.L. - Cancer metastasis: tumor cells and host organ properties important in metastasis to specific secondary sites. Biochim Biophys Acta, 948:175-224, 1988. DOI: https://doi.org/10.1016/0304-419X(88)90010-8

LICHTNER, R.B.; BELLONI, P.N.; NICOLSON, G.L. - Differential adhesion of metastatic rat mammary carcinoma cells to organ-derived microvessei endotelial cells and subendothelial matrix. Expl Cell Biol, 57: 146-52, 1989. DOI: https://doi.org/10.1159/000163518

RUSCIANO, D. et al. - Why do cancer cells metastasis into particular organs? Bioessays, 14(3):1 85-94, 1992. DOI: https://doi.org/10.1002/bies.950140309

RADINSKY, R. - Groth factors and their receptors in metastasis. Semin Cancer Biol, 2(3):1 69-77, 1991.

MORIKAWA, K. et al. - invivo selection of highiy metastatic cells from surgical specimens of different colon carcinomas implanted into nude mice. Cancer, 48:1943-8, 1988.

BROWDER, T.M.; DUNBAR, C.E.; NIENHUIS, A.W. - Private and public autocrine loops in neoplasic cells. CancerCe/Is, 1.9-17, 1989.

RODECK, A. et al. - Metastatic but not primary melanoma cell lines grow in vitro independentiy of exogenous growth factors. Int J Cancer, 40:487-90, 1987. DOI: https://doi.org/10.1002/ijc.2910400520

RVOSLAHTI, E.; YAMAGUCHI, Y. - Proteogiycans as modulators of growth factor activities. Cell, 64:867-9, 1991. DOI: https://doi.org/10.1016/0092-8674(91)90308-L

CHACKAL-ROY, M. et al. - Stimulation of human prostatic carcinom ceM growth by factors present in human bone marrow. J Clin lnvest, 84.43-50, 1989. DOI: https://doi.org/10.1172/JCI114167

ANKLESARIA, P. et al. - Cell-cell adhesion mediated by binding of membrane-anchored transforming growth factor alfa to epidermal growth factor receptors promotes cell proliferation. Proc Nati Acad Sci USA, 872289-92, 1990. DOI: https://doi.org/10.1073/pnas.87.9.3289

PLOWMAN, G.D. et al. - The amphireguiin gene encodes a novel epidermai grow factor-reiated protein with tumor inhibitory activity. MoI Celi Biol, 10:1969-81, 1990. DOI: https://doi.org/10.1128/MCB.10.5.1969

MEAD, J.E.; FAUSTO, N. —Transforming growth fator may be a physiological regulator of liver regeneration by means of an autocrine mechanism. Proc Nati Acad Sci USA, 86:1558-62, 1989. DOI: https://doi.org/10.1073/pnas.86.5.1558

VAN DALE, P.; GALAND, P. - Effect of partial hepatectomy on experimental liver invasion by intraportaiiy injected colon carcinoma cells in rats. Invasion Metastasis, 8:217-27, 1988.

FOLKMAN, J.; MERLER, E.; ALBERNATHY, C. et al. - isolation of a tumor factor responsible for angiogenesis. J Exp Med, 133:275-88, 1971. DOI: https://doi.org/10.1084/jem.133.2.275

FURCHT, L.T. - Critical factors controlling angiogenesis: cell products, cell matrix, growth factors. Lab Invest, 55.505-9, 1986.

D'AMORE, P.A.; KLAGSBRUN, M. —Angiogenesis: factors and mechanisms, in Sirica, A.E. (ed): The pathobiology of neoplasia. Nova York, Plenun, pp. 513-32, 1989. DOI: https://doi.org/10.1007/978-1-4684-5523-6_27

SCHREIBER, A.B.; WINKLER, M.E.; DERNYCK, R. - Transforming growth factor-alpha: a more potent angiogenic mediator than epidermal growth factor. Science, 232:1250-3, 1986. DOI: https://doi.org/10.1126/science.2422759

LIOTTA, L.A.; STETLER-STEVENSON, W.G. - Principles of molecular cell biology of cancer: Cancer Metastasis, in Devita. V.T., Heliman, 5., Rosemberg, S.A. (eds): Cancer Principles and Practice of Oncology, Philadelphia, PA, Lippincott, pp 98-115, 1989.

OLDEN, K. - Experimental approaches for the prevention of hematogeneous metastasis. Oncology, 11.83-100, 1989.

GOLDFARB, R.H.; BRUNSON, K.W. - Overview of current understanding of tumor spread. Fundamental Aspects of Cancer. Dorchecht, Netherlands Kluwer Academic, 1989. DOI: https://doi.org/10.1007/978-94-009-1089-8_3

POLLACK, V.A. - Therapy of metastasis in animal models, in 011dfarb, R.H. (ed.). Fundamental Aspects of Cancer. Boston, MA, Kluwer Academic, 192-200, 1989. DOI: https://doi.org/10.1007/978-94-009-1089-8_18

ZACHARSKI, L.R. et al. - Effect of warfarin anticoagulant on survival in carcinoma of the lung. Cancer, 53.2046-52, 1984. DOI: https://doi.org/10.1002/1097-0142(19840515)53:10<2046::AID-CNCR2820531007>3.0.CO;2-F

GIRALDi, T.; SAVA, G. - Selective antimetastatic drugs (review). Anticancer Res, 1:1 63-74, 1987.

GORELIK, G.; GUNJI, Y; GOLDFARB, R.H. - interaction of tumor cells and immune system in the metastatic process. Biochem Cell Biol, 66:617-25, 1988. DOI: https://doi.org/10.1139/o88-071

FIDLER, I.J. - Macrophages and metastasis— biological approach to cancer therapy: Presidential Address. Cancer Res, 45:4714-26, 1985.

Downloads

Publicado

2023-06-02

Como Citar

1.
Pitrez FAB, Lemchem HF, Grossmann R, Furtado JP, Magalhães RB, Castilho R. Metástase, uma visão atualizada. Rev. Bras. Cancerol. [Internet]. 2º de junho de 2023 [citado 3º de julho de 2024];41(2):81-7. Disponível em: https://rbc.inca.gov.br/index.php/revista/article/view/2931

Edição

Seção

ARTIGO ORIGINAL

Artigos mais lidos pelo mesmo(s) autor(es)