Viabilidade de um Programa de Intervenção para Incentivo à Atividade Física e Alimentação Saudável para Sobreviventes ao Câncer de Endométrio
DOI:
https://doi.org/10.32635/2176-9745.RBC.2025v71n2.4737Palavras-chave:
Obesidade, Neoplasias do Endométrio, Sobreviventes de Câncer, Estilo de VidaResumo
Introdução: Sobreviventes de câncer apresentam maior risco de desenvolver doenças crônicas não transmissíveis (DCNT) e podem se beneficiar de intervenções focadas em mudanças no estilo de vida, escassas nos países em desenvolvimento. Objetivo: Avaliar a viabilidade de um programa de aconselhamento para alimentação saudável e atividade física em sobreviventes de câncer de endométrio. Método: Ensaio clínico randomizado aninhado à coorte prospectiva que incluiu mulheres com câncer de endométrio entre 20-69 anos, tratadas cirurgicamente e randomizadas em Grupo Controle (GC) e Grupo Intervenção (GI), após o procedimento. A viabilidade foi avaliada pelas taxas de recrutamento, adesão e retenção. A eficácia foi testada pela avaliação antropométrica, laboratorial, ingestão alimentar, testes de capacidade funcional e nível de atividade física. Para análise estatística, foram ajustados os modelos lineares mistos para avaliar o efeito da intervenção nos grupos, considerando as diferentes medidas repetidas dos desfechos ao longo do tempo. Foi considerado estatisticamente significativo p<0,05. Resultados: O GI apresentou redução estatisticamente significante na insulina sérica, no teste “levantar e caminhar”, e no consumo energético diário. Houve diferença estatisticamente significante entre os grupos para variáveis antropométricas, para as quais se observou variação positiva entre o Tempo 0 e Tempo 3 no GC e negativa no GI. Taxas de recrutamento, adesão e retenção foram de 52,1%, 64,5% e 90,3%, respectivamente. Conclusão: A intervenção mostrou-se viável nessa população, embora sejam necessários ajustes no formato da intervenção. No entanto, com resultados modestos nos parâmetros antropométricos e de ingestão alimentar, estudos com maior tamanho amostral são necessários para adequada avaliação da sua eficácia.
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Referências
Ferlay J, Ervik M, Lam F, et al. Global Cancer Observatory [Internet]. Lyon: International Agency for Research on Cancer; 2020. Cancer today [acesso 2025 jan 28]. Disponível: https://gco.iarc.fr/today
Instituto Nacional de Câncer. Estimativa 2023: incidência de câncer no Brasil [Internet]. Rio de Janeiro: INCA; 2022. [acesso 2025 jan 28]. Disponível em: https://www.inca.gov.br/sites/ufu.sti.inca.local/files//media/document//estimativa-2023.pdf
National Institute of Health [Internet]. Whasitgton, D. C.: NIH; [Sem data]. Cancer stat facts: uterine cancer. [acesso 2024 jun 1]. Disponível em: https://seer.cancer.gov/statfacts/html/corp.html
Everett E, Tamimi H, Greer B, et al. The effect of body mass index on clinical/pathologic features, surgical morbidity, and outcome in patients with endometrial cancer. Gynecol Oncol. 2003;90(1):150-7. doi: https://www.doi.org/10.1016/S0090-8258(03)00232-4 DOI: https://doi.org/10.1016/S0090-8258(03)00232-4
Arem H, Chlebowski R, Stefanick ML, et al. Body mass index, physical activity, and survival after endometrial cancer diagnosis: results from the Women's Health Initiative. Gynecol Oncol. 2013;128(2):181-6. doi: https://www.doi.org/10.1016/j.ygyno.2012.11.041 DOI: https://doi.org/10.1016/j.ygyno.2012.10.029
Kuiper JG, Phipps AI, Neuhouser ML, et al. Recreational physical activity, body mass index, and survival in women with colorectal cancer. Cancer Causes Control. 2012;23(12):1939-48. doi: https://www.doi.org/10.1007/s10552-012-0071-2 DOI: https://doi.org/10.1007/s10552-012-0071-2
Nelson SH, Marinac CR, Patterson RE, et al. Impact of very low physical activity, BMI, and comorbidities on mortality among breast cancer survivors. Breast Cancer Res Treat. 2016;155(3):551-7. doi: https://www.doi.org/10.1007/s10549-016-3694-2 DOI: https://doi.org/10.1007/s10549-016-3694-2
Demark-Wahnefried W, Aziz NM, Rowland JH, et al. Riding the crest of the teachable moment: promoting long-term health after the diagnosis of cancer. J Clin Oncol. 2005;23(24):5814-30. doi: https://www.doi.org/10.1200/JCO.2005.01.230 DOI: https://doi.org/10.1200/JCO.2005.01.230
Koutoukidis DA, Beeken RJ, Manchanda R. et al. Diet and exercise in uterine cancer survivors (DEUS pilot) - piloting a healthy eating and physical activity program: study protocol for a randomized controlled trial. Trials. 2016;17(1):130. doi: https://www.doi.org/10.1186/s13063-016-1260-1 DOI: https://doi.org/10.1186/s13063-016-1260-1
Adams SA, Choi SK, Khang L, et al. Decreased cancer mortality-to-incidence ratios with increased accessibility of federally qualified health centers. J Community Health. 2015;40(4):633-41. doi: https://www.doi.org/10.1007/s10900-014-9972-9 DOI: https://doi.org/10.1007/s10900-014-9978-8
Clinton SK, Giovannucci EL, Hursting SD. The world cancer research fund/American Institute for Cancer research third expert report on diet, nutrition, physical activity, and cancer: impact and future directions. J Nutr. 2020;150(4):663-71. doi: https://www.doi.org/10.1093/jn/nxz268 DOI: https://doi.org/10.1093/jn/nxz268
Silva GA, Rezende LFMD, Gomes FDS, et al. Modos de vida entre pessoas que tiveram câncer no Brasil em 2013. Ciênc saúde coletiva. 2016;21(2):379-88. doi: https://www.doi.org/10.1590/1413-81232015211.24722015 DOI: https://doi.org/10.1590/1413-81232015211.24722015
Hoedjes M, Kruif A, Mols F, et al. An exploration of needs and preferences for dietary support in colorectal cancer survivors: a mixed-methods study. PLoS One. 2017;12(12):e0189178. doi: https://www.doi.org/10.1371/journal.pone.0189178 DOI: https://doi.org/10.1371/journal.pone.0189178
Von Gruenigen VE, Courneya KS, Gibbons HE, et al. Feasibility and effectiveness of a lifestyle intervention program in obese endometrial cancer patients: a randomized trial. Gynecol Oncol. 2008;109(1):19-26. doi: https://www.doi.org/10.1016/j.ygyno.2007.12.026 DOI: https://doi.org/10.1016/j.ygyno.2007.12.026
Basen-Engquist K, Carmack C, Brown J, et al. Response to an exercise intervention after endometrial cancer: differences between obese and non-obese survivors. Gynecol Oncol. 2014;133(1):48-55. doi: https://www.doi.org/10.1016/j.ygyno.2014.01.046 DOI: https://doi.org/10.1016/j.ygyno.2014.01.025
McCarroll ML, Armbruster S, Pohle-Krauza RJ, et al. Feasibility of a lifestyle intervention for overweight/obese endometrial and breast cancer survivors using an interactive mobile application. Gynecol Oncol. 2015;137(3):508-15. doi: https://www.doi.org/10.1016/j.ygyno.2014.12.025 DOI: https://doi.org/10.1016/j.ygyno.2014.12.025
Guibu IA, Moraes JC, Guerra Junior AA, et al. Características principais dos usuários dos serviços de atenção primária à saúde no Brasil. Rev Saude Publica. 2017;51(Supl 2):17s. doi: https://www.doi.org/10.11606/S1518-8787.2017051007070 DOI: https://doi.org/10.11606/S1518-8787.2017051007070
Viacava F, Oliveira RADD, Carvalho CDC, et al. SUS: oferta, acesso e utilização de serviços de saúde nos últimos 30 anos. Ciênc saúde coletiva. 2018;23(6):1751-62. doi: https://www.doi.org/10.1590/1413-81232018236.06022018 DOI: https://doi.org/10.1590/1413-81232018236.06022018
Lima Júnior JCC, Santos SMS, Silva KT, et al. Perfil sociodemográfico e clínico de usuários assistidos por uma Estratégia Saúde da Família. RSD. 2022;11(13):e06111335071. doi: https://www.doi.org/10.33448/rsd-v11i13.35071 DOI: https://doi.org/10.33448/rsd-v11i13.35071
Dombrowski SU, Endevelt R, Steinberg DM, et al. Do more specific plans help you lose weight? Examining the relationship between plan specificity, weight loss goals, and plan content in the context of a weight management programme. Br J Health Psychol. 2016;21(4):989-1005. doi: https://www.doi.org/10.1111/bjhp.12212 DOI: https://doi.org/10.1111/bjhp.12212
Daley AJ, Crank H, Mutrie N, et al. Patient recruitment into a randomised controlled trial of supervised exercise therapy in sedentary women treated for breast cancer. Contemp Clin Trials. 2007;28(5):603-13. doi: https://www.doi.org/10.1016/j.cct.2007.02.009 DOI: https://doi.org/10.1016/j.cct.2007.02.009
Korde LA, Micheli A, Smith AW, et al. Recruitment to a physical activity intervention study in women at increased risk of breast cancer. BMC Med Res Methodol. 2009;9:27. doi: https://www.doi.org/10.1186/1471-2288-9-27 DOI: https://doi.org/10.1186/1471-2288-9-27
Department of Health (UK). Developing a specification for lifestyle weight management services [Internet]. London: Obesity and Food Policy Branch; 2013. [Acesso 2024 dez 10]. Disponível em: https://assets.publishing.service.gov.uk/media/5a75911f40f0b6360e475174/Weight_Management_Service_Spec_FINAL_with_IRB.pdf
Silva CL, Costa AF, Camara AO, et al. Association between ultra-processed food consumption and excess of weight in women with endometrial cancer. Nutr Cancer. 2022;74(3):927-37. doi: https://www.doi.org/10.1080/01635581.2021.1944230 DOI: https://doi.org/10.1080/01635581.2021.1944230
Fernandes JPA, Camara AO, Frajacomo FT, et al. Metabolic profile of patients with endometrial adenocarcinoma and association with tumor grade. Int J Gynecol Cancer. 2022;32(5):626-32. doi: https://www.doi.org/10.1136/ijgc-2021-003245 DOI: https://doi.org/10.1136/ijgc-2021-003245
Roberts HC, Denison HJ, Martin HJ, et al. A review of the measurement of grip strength in clinical and epidemiological studies: towards a standardised approach. Age Ageing. 2011;40(4):423-9. doi: https://www.doi.org/10.1093/ageing/afr051 DOI: https://doi.org/10.1093/ageing/afr051
Jones CJ, Rikli RE, Beam WC. A 30-s chair-stand test as a measure of lower body strength in community-residing older adults. Res Q Exerc Sport. 1999;70(2):113-9. doi: https://www.doi.org/10.1080/02701367.1999.10608028 DOI: https://doi.org/10.1080/02701367.1999.10608028
Podsiadlo D, Richardson S. The timed “Up & Go”: a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc. 1991;39(2):142-8. doi: https://www.doi.org/10.1111/j.1532-5415.1991.tb01616.x DOI: https://doi.org/10.1111/j.1532-5415.1991.tb01616.x
Rikli R, Jones C. Functional fitness normative scores for community-residing older adults, ages 60-94. J Aging Phys Act. 1999;7(1):162-81. doi: https://www.doi.org/10.1123/japa.7.2.162 DOI: https://doi.org/10.1123/japa.7.2.162
Schmidt K, Vogt L, Thiel C, et al. Validity of the six minute walk test in cancer patients. Int J Sports Med. 2013;34(7):631-6. doi: https://www.doi.org/10.1055/s-0032-1323746 DOI: https://doi.org/10.1055/s-0032-1323746
American Thoracic Society. ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med. 2002;166(1):111-7. doi: https://www.doi.org/10.1164/ajrccm.166.1.at1102 DOI: https://doi.org/10.1164/ajrccm.166.1.at1102
Burnetto AF, Paulin E, Yamaguti WPS. Comparação entre a escala modificada de Borg e a escala de Borg modificada analógico visual aplicadas em pacientes com dispneia. Braz j phys ther (Impr.). 2002;6(1):41-5. Disponível em: https://pesquisa.bvsalud.org/portal/resource/pt/lil-315309
Craig CL, Marshall AL, Sjöström M, et al. International physical activity questionnaire: 12-country reliability and validity. Med Science in Sports Exerc. 2003;35(8):1381-95. doi: https://www.doi.org/10.1249/01.MSS.0000078924.61453.FB DOI: https://doi.org/10.1249/01.MSS.0000078924.61453.FB
Matsudo S, Araújo T, Matsudo V, et al. International physical activity questionnaire (IPAQ): study of validity and reliability in Brazil. Rev Bras ativ fis saúde. 2001;6(2):5-18. doi: https://www.doi.org/10.12820/rbafs.v.6n2p5-18
SPSS®: Statistical Package for Social Science (SPSS) [Internet]. Versão 20.0. [Nova York]. International Business Machines Corporation. [acesso 2024 mar 9]. Disponível em: https://www.ibm.com/br-pt/spss?utm_content=SRCWW&p1=Search&p4=43700077515785492&p5=p&gclid=CjwKCAjwgZCoBhBnEiwAz35Rwiltb7s14pOSLocnooMOQh9qAL59IHVc9WP4ixhNTVMjenRp3-aEgxoCubsQAvD_BwE&gclsrc=aw.ds
R: The R Project for Statistical Computing [Internet]. Version 4.2.3 Chicago: The R foundation. 2021 Nov 2 - [acesso 2024 set 6]. Disponível em: https://www.r-project.org/
Conselho Nacional de Saúde (BR). Resolução n° 466, de 12 de dezembro de 2012. Aprova as diretrizes e normas regulamentadoras de pesquisas envolvendo seres humanos. Diário Oficial da União, Brasília, DF. 2013 jun 13; Seção I:59.
Ministério da Saúde (BR). Guia alimentar para a população brasileira [Internet]. Brasília, DF: MS; 2014. [acesso 2024 set 6]. Disponível em: https://bvsms.saude.gov.br/bvs/publicacoes/guia_alimentar_populacao_brasileira_2ed.pdf
Williams VA, Brown NI, Johnson R, et al. A web-based lifestyle intervention for cancer survivors: feasibility and acceptability of SurvivorSHINE. J Cancer Educat. 2022;37(6):1773-81. doi: https://www.doi.org/10.1007/s13187-021-02026-x DOI: https://doi.org/10.1007/s13187-021-02026-x
Lucas AR, Focht BC, Cohn DE, et al. A Mindfulness-based lifestyle intervention for obese, inactive endometrial cancer survivors: a feasibility study. Integrative cancer therapies. 2017;16(3):263-75. doi: https://www.doi.org/10.1177/1534735416668257 DOI: https://doi.org/10.1177/1534735416668257
Edbrooke L, Khaw P, Freimund A, et al. EnhAncing lifestyle behaviors in endometrial cancer (ENABLE): a pilot randomized controlled trial. Integr Cancer Ther. 2022:21. doi: https://www.doi.org/10.1177/15347354211069885 DOI: https://doi.org/10.1177/15347354211069885
Cooley ME, Sarna L, Brown JK, et al. Challenges of recruitment and retention in multisite clinical research. Cancer Nurs. 2003;26(5):276-86. doi: https://www.doi.org/10.1097/00002820-200310000-00006 DOI: https://doi.org/10.1097/00002820-200310000-00006
Crane TE, Badger TA, O'Connor P. Lifestyle intervention for Latina cancer survivors and caregivers: the nuestra salud randomized pilot trial. J Cancer Surviv. 2021;15(4):607-19. doi: https://www.doi.org/10.1007/s11764-020-00954-z DOI: https://doi.org/10.1007/s11764-020-00954-z
Lynch BM, Nguyen NH, Moore MM, et al. A randomized controlled trial of a wearable technology-based intervention for increasing moderate to vigorous physical activity and reducing sedentary behavior in breast cancer survivors: the ACTIVATE Trial. Cancer. 2019;125(16):2846-55. doi: https://www.doi.org/10.1002/cncr.32143 DOI: https://doi.org/10.1002/cncr.32143
Rees-Punia E, Leach CR, Westmaas JL, et al. Pilot randomized controlled trial of feasibility, acceptability, and preliminary efficacy of a web-based physical activity and sedentary time intervention for survivors of physical inactivity-related cancers. Int J Behav Med. 2022;29(2):220-9. doi: https://www.doi.org/10.1007/s12529-021-09999-5 DOI: https://doi.org/10.1007/s12529-021-09999-5
Lawn S, Zrim S, Leggett S, et al. Is self-management feasible and acceptable for addressing nutrition and physical activity needs of cancer survivors? Health Expect. 2015;18(6):3358-73. doi: https://www.doi.org/10.1111/hex.12327 DOI: https://doi.org/10.1111/hex.12327
Gorzelitz J, Costanzo E, Gangnon R, et al. Feasibility and acceptability of home-based strength training in endometrial cancer survivors. J Cancer Surviv. 2023;17(1):120-9. doi: https://www.doi.org/10.1007/s11764-021-00990-3 DOI: https://doi.org/10.1007/s11764-021-00990-3
Fleming S, Jones T, Janda M, et al. Physical activity trajectories following gynecological cancer: results from a prospective, longitudinal cohort study. Inter J Gynecol Cancer. 2020;30(11):1784-90. doi: https://www.doi.org/10.1136/ijgc-2020-001543 DOI: https://doi.org/10.1136/ijgc-2020-001543
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