The analysis of DNA ploidy and the percentage of S phase cells determined by flow cytometry and other prognostic variables in primary breast carcinomas
DOI:
https://doi.org/10.32635/2176-9745.RBC.1998v44n1.2797Keywords:
Breast Cancer, Flow Cytometry, Cell Proliferation, DNA Contente, PrognosisAbstract
This stucly shows the content analysis of DNA ploidy and the percentage of S phase cells determined by flow cytometry and other prognostic variable in 69 specimens of breast carcinomas. A significant association between DNA ploidy and the tumor size, estrogen and progesterone receptors, was noticed. Also another association was identified between the percentage of S phase and menstrual status, estrogen receptors, and axillary node metastases. Tumors classified as DNA aneuploid, with Sphase higger than 7.15 presented more metastasis and smaller survival compared to DNA diploid tumors and S phase lower than 7.15. According to the prognostic point of view, the importance of the DNA study was demonstrated privately for the axillary node negative group.
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