Cancer biopsychosocial and psychoneuroimmunologic effects on patients and their families
DOI:
https://doi.org/10.32635/2176-9745.RBC.1997v43n2.2844Keywords:
Cancer, Psychoneuroimmunology, Stress, Quality of LifeAbstract
During the last tvvo decades, it has been stressed the somatic, psvchic and social problems of cancer patients, as weli as biopsvchosociai and psvchoneuroimmunoiogic theories have been emphasized on oncologic research. This paper presents clinical considerations about psychoneuroinnnunoiogic biopsychosocialjactors ia Oncology, and points cancer impact on patients and their relatives. Cancer and its treatments create a stress which is imposed upon patients and their relatives, with the power of onsetting adjustment disorders in all of them. An assessement of the quality of life must be incorporated in clinical studies, because it may improve therapeutic approaches. Patients' reports 0n somatic svmptoms are mainly associated with their emocional and social concerning rather than with their general health status. The staff responsible for the patients must understand the family/patient dynamics and be aware of the influence of psychosocial issues. Falure in recognizing that, and consequently imnpairing the family’s psychosocial support will deprive the patients of comfort, love, support, and friendship that they will need through the course of the disease. Physicians must be able to facilitate the adaptation process of their patients. Psvchologic treatment is always beneficial, at least to some extent.
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Latchman, D.S.- Transcription-factor mutations and disease. N Engi J Med, 334(1): 28-33, 1996. DOI: https://doi.org/10.1056/NEJM199601043340108
Bernhard, J.; Ganz, P.A. – Psychosocial issues in lung cancer patients (part 1). Chest, 99: 216-23, 1991. DOI: https://doi.org/10.1378/chest.99.1.216
Bovbjerg, D.H. - Psychoneuroimmunology: implications for Oncology? Cancer 67: 828-32, 1991. DOI: https://doi.org/10.1002/1097-0142(19910201)67:3+<828::AID-CNCR2820671413>3.0.CO;2-A
Deitos, F.H.; Gaspary, J.F.P. - Psiconeuroimunologia: Aspectos Biopsicossociais. J Bras Psiquiatria, in press, 1997.
Deitos, F.H.; Gaspary, J.F.P.; Lopes, S.A.; De Lima, G.L.; Staats, CO. – As implicações psiconeuroimunológicas do estresse no desencadeamento de doenças. JBM: in press, 1997.
Deitos, F.H.; Gaspary, J.F.P. – Implicações Clínicas das Teorias Psiconeuroimunológicas. Psiq Biol, 4(3): 127-136, 1996.
Hughes, J.E. - Depressive illness and lung cancer. II: follow-up of inoperable patients. EurJSurg Oncol, 11:21-4, 1985.
Solomon, G.F.; Amkraut, A.A. - Psychoneuroendocrinological effects on the immune response. Ann Rev Microbiol, 35: 155-84, 1981. DOI: https://doi.org/10.1146/annurev.mi.35.100181.001103
Surman, O.S. - Possible immunological effects of psychotropic medication. Psychosoniatics, 34(2): 139-43, 1993. DOI: https://doi.org/10.1016/S0033-3182(93)71904-0
Zonderman, A.B.; Costa, P.T.; McCrae, R.R. - Depression as a risk for câncer morbidity and mortality in a nationaily representative sample. JAMA, 262: 1191- 231, 1988. DOI: https://doi.org/10.1001/jama.1989.03430090053032
Walker, L.G.; Eremin, O. - Psychoneuroimmunology: a new fad or the fifth cancer treatment modality? Ani J Surgery, 170: 2-4, 1995. DOI: https://doi.org/10.1016/S0002-9610(99)80241-4
Paiva, L.; Da Silva, A. – Medicina Psicossomática, Artes Médicas, Porto Alegre (RS), 874, 1994.
Trzepacz, PT.; Levenson, J.L.; Tringali, R.A. - Psychopharmacology and neuropsychiatric syndromes in organ transplantation. Gen Hosp Psychiatry, 13: 223-45, 1991. DOI: https://doi.org/10.1016/0163-8343(91)90124-F
Razavi, D.; Delvaux, N. - The Psychiatrist's Persepctive on Quality of Life and Quality of Care in üncology: concepts, symptom management, communcation issues. Eur J Cancer,31A (Supp1. 6): S25-S29, 1995. DOI: https://doi.org/10.1016/0959-8049(95)00490-A
Kaasa, S. - Using quality of life assessment methods in patients with advanced cancer: a clinical perspective. Eur J Cancer, 31A(Supp1. 6): S 1, 1995. DOI: https://doi.org/10.1016/0959-8049(95)00493-3
Aapro, M.S. - Foreword. Eur J Cancer, 31A(Supp1. 6): Si, 1995. DOI: https://doi.org/10.1016/0959-8049(95)00360-U
Berkman, B.J.; Sampson, S.E. - Psychosocial effects of cancer economics on patients and their families. Cancer, 72: 2846-9, 1993. DOI: https://doi.org/10.1002/1097-0142(19931101)72:9+<2846::AID-CNCR2820721515>3.0.CO;2-3
Bernhard, J.; Ganz, P.A. – Psychosocial issues in lung cancer patients (part 2). Chesr, 99: 480-85, 1991. DOI: https://doi.org/10.1378/chest.99.2.480
Harrison, J.; Maguire, P. - Predictors of psychiatric morbidity in Cancer Patients. Br J Psychiatr 165: 593-598, 1994. DOI: https://doi.org/10.1192/bjp.165.5.593
Kissane, D.W. - Perceptions of family functioning and cancer. Psycho-Oncology, 3: 259-69, 1994. DOI: https://doi.org/10.1002/pon.2960030403
Mello, F.J. - Psicossomática hoje. Ed Artes Médicas, Porto Alegre (RS), 1992.
Trhsburg, R.W.; Van Knippenberg, F.C.; Rijpma, S.E. - Effects of psychological treatment on cancer patients: a critical review. Psychossomatic Med, 54: 489-517, 1992. DOI: https://doi.org/10.1097/00006842-199207000-00011
Derogatis, L.R.; Morrow, G.R.; Fetting, J. et al. - The prevalence of psychiatric disorders among cancer patients. JAMA, 249: 751-757, 1983. DOI: https://doi.org/10.1001/jama.249.6.751
Koller, M.; Kussman, J., Lorenz, W. et al. - Symptom Reporting in Cancer Patients. The role of negative affect and Experienced social stigma. Cancer 77: 983- 95, 1996. DOI: https://doi.org/10.1002/(SICI)1097-0142(19960301)77:5<983::AID-CNCR27>3.0.CO;2-Z
Ahmedzai, S. - Recent Clinical Trials of Pain Control: impact on quality of life. Eur J Cancer, 31A (Supp1. 6): S2-S7, 1995. DOI: https://doi.org/10.1016/0959-8049(95)00496-6
Biack, P.H. - Central Nervous System-Immune System Interactions: Psychoneuroendocrinology of Stress and its immune consequences. Antimicrobial Agents and Chemotheapy, 38(1): 1-6, 1994. DOI: https://doi.org/10.1128/AAC.38.1.1
Faliowfield, L. - Heiping the relatives of patients with cancer. Eur J Cancer, 31A(11): 1731-32, 1995. DOI: https://doi.org/10.1016/0959-8049(95)00471-T
Harrison, J.; Haddad, P.; Maguire, P. – The Impact of Cancer on Key Relatives: a comparison of relative and patient concerns. EurJ Cancer 31A(JI): 1736-40, 1995. DOI: https://doi.org/10.1016/0959-8049(95)00389-Z
Deitos, F.H.; Staats, C.G.; Lima, G.L.; Lopes, 5V.; Antoneilo, F.; Nascimento, L.L.; Gaspary, J.F.P. - Estresse e depressão, alterações neuroendócrinas e conseqüências imunológicas. Inform Psiq, 15(3): 83-89, 1996.
Breyer, J.- The adjustment of siblings of pediatric cancer patients - a sibling and parent perspective. Psycho-üncology, 2:201-208, 1993. DOI: https://doi.org/10.1002/pon.2960020306
Welch, A.S.; Wadsworth, M.E.; Compas, B.E. - Adjustment of chiidren and adolescents to parental cancer - Parents' and Children's perspectives. Cancer 77: 1409-18, 1996. DOI: https://doi.org/10.1002/(SICI)1097-0142(19960401)77:7<1409::AID-CNCR28>3.0.CO;2-4
Ader, R.; Cohen, N.; Felten, D. Psychoneuroimmunology: interactions between the nervous system and the imune system. Lancet, 345: 99-103, 1995. DOI: https://doi.org/10.1016/S0140-6736(95)90066-7
Khansari, D.N.; Murgo, A.J.; Faith, R.E. - Effects of stress on the immune system. Immunol Today 11: 170-5, 1990. DOI: https://doi.org/10.1016/0167-5699(90)90069-L
Ader, R. - On the Clinical relevance of Psychoneuroimmunoiogy. Clin Immunol Immunopathol, 64(1): 6-8, 1992. DOI: https://doi.org/10.1016/0090-1229(92)90051-O
Shea, J.D.; Burton, R.; Girgis, A. - Negative affect, absorption, and immunity. Physiology & Behavior, 53: 449-457, 1993. DOI: https://doi.org/10.1016/0031-9384(93)90138-6
Kiecolt-Glaser, J.K.; Glaser, R. - Psychoneuroimmunology: Can Psychological interventions modulate immunity? J Consulting Clin Psychol, 60(4): 569-75, 1992. DOI: https://doi.org/10.1037/0022-006X.60.4.569
Preger, J.; Gauer, G.C.; Von Mühlen, C.A. - Sistema Neuroendócrino e Atividade Imune no Estresse e Depressão. Psiquiatr Biol, 3(1): 14-25, 1995.
Ader, R.; Feltori, D.; Cohen, H. - Interactions between the brain and the immune system. Annu Rev Pharmacol Toxicol, 30: 561-602, 1990. DOI: https://doi.org/10.1146/annurev.pa.30.040190.003021
Cohen, S. - Psychological stress and susceptibility to upper respiratory infections. A,n J Respir Crít Care Mcd, 152: S53-S58, 1995. DOI: https://doi.org/10.1164/ajrccm/152.4_Pt_2.S53
Waidhauser, F.; Ehrhart, B.; Fiirster, E. - Clinical aspects of the melatonina action: impact of development, aging, and puberty, involvement of melatonin in psychiatric disease and importance of neuroimmunoendocrine interactions. Experientia, 49: 671-681, 1993. DOI: https://doi.org/10.1007/BF01923949
Watkins, A.D. - The role of alternative therapies in the treatment of allergic disease. Clinical and Experimental Allergy, 24: 813-25, 1994. DOI: https://doi.org/10.1111/j.1365-2222.1994.tb01804.x
Reiche, E.M.; Inouye, M.M.; Ponteilo, R. - Visão atual: a psiconeuroimunologia. Semina, 12(2): 91-94, 1991. DOI: https://doi.org/10.5433/1679-0367.1991v12n2p91
Glaser, R.; Kiecolt-Glaser, J. - Stress-associated immune suppression and acquired immune deficiency syndrome (AIDS). Adv Biochein Psychopharmacol, 44: 203-15, 1988.
O'Learly, A. - Stress, Emotion, and Human Immune Function. Psychological Bull, 108(3): 363-382, 1990. DOI: https://doi.org/10.1037/0033-2909.108.3.363
Kiecolt-Glaser, J.K.; Glaser, R. - Psy-choneuroimmunology and health consequences: data and shared mechanisms. Psychosom Mcd, 57(3): 269-74, 1995. DOI: https://doi.org/10.1097/00006842-199505000-00008
Whiteside, T.L.; Herberman, R.B. – The role of natural killer cells in human disease. Clin Jmmunol Immunopathol, 53: 1-23, 1989. DOI: https://doi.org/10.1016/0090-1229(89)90096-2
Brittenden, J.; Heys, S.D.; Ross, J. et al. - Natural Killer Cells and Cancer. Cance, 77: 1226-43, 1996. DOI: https://doi.org/10.1002/(SICI)1097-0142(19960401)77:7<1226::AID-CNCR2>3.0.CO;2-G
Holmes, G.P.; Kaplan, J.E.; Gantz, N.M. et al. - Chronic fatigue syndrome: a working case definition. Ann Int Mcd, 108: 387-89, 1988. DOI: https://doi.org/10.7326/0003-4819-108-3-387
Vollhardt, L.T. - Psychoneuroimmunology: a literature review. Amer J Orthopsychiat, 61(1): 35-47, 1991. DOI: https://doi.org/10.1037/h0079226
Irwin, M.; Lacher, U.; Caldwell, C. - Depression and reduced natural killer cytotoxicity: a longitudinal study of depressed patients and control subjects. Psychological Mcd, 22: 1045-1050, 1992. DOI: https://doi.org/10.1017/S0033291700038617
Lin, C.C.; Kuo, Y.C.; Huang, W.C.; Lin, C.Y - Natural Killer Celi activity in lung cancer patients. Chest, 92: 1022-24, 1987. DOI: https://doi.org/10.1378/chest.92.6.1022
Boyce, W.T.; Jensen, E.W.; Cassel, J.C.; Colher, A.M.; Smith, A.H.; Ramey, C.T. - Influence of live events and Family routines on childhood respiratory tract illness. Pediatrics, 60: 609-15, 1977. DOI: https://doi.org/10.1542/peds.60.4.609
Jacobs, M.A.; Spilken, A.Z.; Norman, M.M.; Anderson, L.S. - Life stress and respiratory illness. Psychosom Mcd, 32: 233-42, 1970. DOI: https://doi.org/10.1097/00006842-197005000-00003
Schindler, B.A. - Stress, affective Disorders, and immune function. Mcd Clin NorthAm, 69(3): 585-597, 1985. DOI: https://doi.org/10.1016/S0025-7125(16)31034-3
Fawzy, F.L.; Fawzy, N.W.; Arndt, LA.; Pasmau, R.O. - Critical review of psychosocial interventions in cancer care. Arch Gcn Psychiatr,4 52: 100-113, 1995. DOI: https://doi.org/10.1001/archpsyc.1995.03950140018003
Goldberg, R.J. - Diagnostic dilemas presented by patients with anxiety and depression. AmJMcd, 98: 278-284, 1995. DOI: https://doi.org/10.1016/S0002-9343(99)80375-1
Siegel, K.; Yates, J.W. – Psychosocial barriers to employment of the cancer survivor. J Psychosoc Oncology, 5: 97-109, 1988. DOI: https://doi.org/10.1300/J077v05n04_08
Fawzy, F.L.; Kemeny, M.E.; Fawzy, N.W. et al. -A structured psychiatric intervention for cancer patients. II. Changes over time in immunological mensures. Arch Gcn Psychiatr 47: 729-735, 1990. DOI: https://doi.org/10.1001/archpsyc.1990.01810200037005
Fawzy, F.L.; Fawzy, N.W.; Hyun, C.S. et al. - Malignant melanoma: effects of na early estructured psychiatric intervention, coping, and affective state on recurrence and survival 6 years later. Arch Gen Psychiatry, 50: 681-689, 1993. DOI: https://doi.org/10.1001/archpsyc.1993.01820210015002
Molin, C.; Arrigo, C. - Clinical Triais and Quality of Life Assessment: the nurses's viewpont. Eur J Cancer 31A(Supp1. 6): S8-S10, 1995. DOI: https://doi.org/10.1016/0959-8049(95)00495-5
Cohen, S.R.; Mount, B.M.; Tomas, J.N.; Mount, L.F. - Existencial WeI1-Being is an important determinat of quality of life. Evidence from the McGi11 quality of life questionnaire. Cance, 77: 576-86, 1996. DOI: https://doi.org/10.1002/(SICI)1097-0142(19960201)77:3<576::AID-CNCR22>3.0.CO;2-0
