Epidermoid carcinoma of the female urethra associated with human papillomavirus: a case report
DOI:
https://doi.org/10.32635/2176-9745.RBC.1997v43n3.2850Keywords:
Urethral Carcinoma, Epidermoid Carcinoma, Human Papillomavirus, Urinary ReservoirAbstract
Primary cancer of the female urethra is a rare malignant neoplasm. The authors report a case of a 32-year-old black female patient who came to the medical center with urinary obstruction. Diagnostic investigation showed urethral epidermoid carcinoma as the subjacent cause of the symptom. Radical cystourethrectomy combined with pelvic lymphadenectomy, total hysterectomy, and resection of the anterior vaginal wall with reconstruction of the urinary tract with a continente urinary reservoir (Indiana Pouch Surgery) were performed. A positive reaction, at the immunohistochemical study, for human papillomavirus (HPV) antigen was observed in the tumor. Now, after 12 months offollow-up, the patient is disease-free and has good quality of life.
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References
Hahn, P.; Krepart, G.; Malaker, K.- Carcinoma of female urethra. Manitoba experience: 1958-1987. Urology 37(2): 106-9,1991. DOI: https://doi.org/10.1016/0090-4295(91)80202-I
Wiener, J.S.; Walther, P.J. - A high association of oncogenic human papilloma-viruses with carcinomas of the female urethra: polymerase chain reaction-based analysis of multiple histological types. J Urol, 151:49-53,1994. DOI: https://doi.org/10.1016/S0022-5347(17)34870-X
Barrasso, R.; De Brux J.; Croissant, O.; Orth, G.- High prevalence of papilloma-virus-associated penile intraepithelial neoplasia in sexual partners of women with cervical intraepithelial neoplasia. N E J Med, 37(15): 916-23,1987. DOI: https://doi.org/10.1056/NEJM198710083171502
Wiener,J.S.; Walther, P.J.-The association of oncogenic human pappilomaviruses with urologic malignancy. Surg Oncol Clin N Am, 4(2): 257-76,1995. DOI: https://doi.org/10.1016/S1055-3207(18)30452-6
Wiener, J.S.; Liu, E.T.; Walther, P.J.- Oncogenic human papillomavirus type 16 associated with squamous cell câncer of the male urethra. Câncer Research, 52: 5018- 22,1992.
Villla, L.L.; Lopes, A.- Human papiloma virus DNA sequences in penile carcinomas in Brazil. Int J Cancer, 37: 853-55, 1986. DOI: https://doi.org/10.1002/ijc.2910370610
Grigsby, P.W.; Corn, B.W.-Localized urethral tumors in women: indications for conservative versus exenterati ve therapies. JUrol., 147: 1516-20, 1992 DOI: https://doi.org/10.1016/S0022-5347(17)37614-0