Profilaxia da Sindrome da Toxicidade Precoce por Quimioterapia pelo uso de Antiprostaglandínicos: Corticosteroides ou Cetoprofemo
DOI:
https://doi.org/10.32635/2176-9745.RBC.1986v32n2.3243Keywords:
Cancer Chemotherapy, Precocious Toxicity Syndrome, Anti-Prostaglandins, Ketoprohen, CorticosteroidsAbstract
Twenty-nine patients were studied prospectively and randomly allocated into 2 treatment grupos: treatment S-intravenous hydrocortison (500mg) or dexamethasone (20mg), and treatment K-intramuscular ketoprophen (50mg 3x); both treatments were associated with intravenous metoclopramide (20mg). All patients received non-cisplatin containing regimens of chemo therapy. We did not observe differences between the 2 treatments for nausea, vomiting, anorexia, asthenia, arthralgias/myalgias, somnolence, insomnia, and semi-quantitatively for all the symptoms of the precocious toxicity syndrome (PTS). We concluded that ketoprophen is as useful as corticosteroids for prophylaxis of PTS, and that results point to the pathogenic model which involves the mediation of prostaglandins and leucotriens in the genesis of PTS.
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References
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