Valor do Antígeno Carcinoembriônico no Acompanhamento das Neoplasias Malignas do Trato Gastrentérico
DOI:
https://doi.org/10.32635/2176-9745.RBC.1986v32n2.3245Keywords:
Carcinoembrionic Antigen, Cancer Marker, Radioimmunoassay, ScintigraphyAbstract
The role of sequential determination of CEA levels in patients with malignant tumors of the G. I. tract was evaluated. Sixty one patients had their history reviewed: 22 beared rectal lesions (36,06%), 18 had large bowel lesions (29,54%), eight had gastric tumors (13,11%), five had sigmoid lesions (8,19%), four had anal canal lesions (6,55%) and four had cecum lesions (6,55%). High levels of CEA and the presence of tumor were associated in 63% of the patients, and in 60,6% of those with metastatic disease high levels of CEA were also found. Adenocarcinoma was the most common histologic type found and CEA levels were high in all well differentiated tumors. High levels of CEA correlated better with the presence of metastatic disease than did liver scintigraphy. This was made clear by the findings of abnormal levels of CEA and normal scintigraphy. Survival of patients with normal preoperative levels of CEA was 100%. Of those patients with abnormal preoperative CEA levels, only 40% were alive af ter 36 months. The possible interferences in serum dosages of CEA and its interpretation, the importance of measuring the tumor marker in tissues, and the need of establishing preoperative follow-up protocols for the better assesment of the CEA dosages and the better evaluation of malignant G. I. tract tumors are stressed.
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References
Gold P, Freedman SO. Specific Carcinoembryonic Antigens of the Human Digestive System. J Expti Med. 1965; 122: 467-481. DOI: https://doi.org/10.1084/jem.122.3.467
Mach JP, Pusztaszeri G. lmmunochemistry. 1972; 9: 1031-1033. DOI: https://doi.org/10.1016/0019-2791(72)90113-9
Thomson DMP, Krupey J, Freedman SO, et al. The radioimmunoassay of circulating carcinoembryonic antigen of the human digestive system. Proc Nati Acad USA. 1972; 64: 161-169. DOI: https://doi.org/10.1073/pnas.64.1.161
Zamcheck N, Moore TL, Dhar P, Kupchik H. lmmunologic diagnosis and prognosis of human tract Cancer: Carcinoembrionic antigens. N Engiand J Me. 1972; 286:83-86. DOI: https://doi.org/10.1056/NEJM197201132860207
Pathologic Basis of Disease, 2 Edition. Edited Stanley R Robbins, 1982.
Staab HJ, Auderer FA, Stumpf E, Fischer - Are circulating CEA immune complexes a prognostic marker in patients with carcinoma of the gastrointestinal tract. Br J Cancer. 1980; 42: 26-33. DOI: https://doi.org/10.1038/bjc.1980.199
Staab HJ, Auderer FA, Ahlemann L. Frammhold W. CEA - Monitoring of patients with carcinomas of the breast, lung bladder and esophagus in radiotherapy in Lenman F ed Carcinoembryonic Proteins, New York: Elsevier. 1979: 151. 172.
Vay Liang W Go, Norman Zamcheck. The role of tumors markers in the management of colorectal cancer. Cancer 1982; SO: 261 8-2623.
Staab H, Auderer FA, Stumpf E, Fischer R. Post operative differentiation of focal tumor recurrence and generalized metastasing in patients with adenocarcinomas of the digestives system by CEA follow-up study. Seand J lmmunol. 1978; 8: 459-464. DOI: https://doi.org/10.1111/j.1365-3083.1978.tb03960.x
Mansour E, Hstert M, Park C, Petreili M. lmmunohistochemical localization of carcinoembryonic antigen in breast cancer tissue and correlation with serum calues and pathology. Am Assoc Cancer Res. 1980; 21:193-201.
Attiyeh FF, Stearns MW. Second-book laparotomy based on CEA elevations in colorectal cancer. Cancer. 1981; 47: 2119-2125. DOI: https://doi.org/10.1002/1097-0142(19810501)47:9<2119::AID-CNCR2820470903>3.0.CO;2-7
Goldenberg DM, Nevilie M, Carter AC, et al. Carcinoembryonic antigen: Its role as a marker in the management of cancer. A National Inst of Health Consensus Development Conference. 1981; 94: 402-409. DOI: https://doi.org/10.7326/0003-4819-94-3-407
