Radiotherapy of Cancer of the Cervix Utery - Occurrence of Actinic Fibrosis in the Subcutaneous Tissue

Authors

  • Marcos Valdemar Laderman Radioterapeuta do Instituto de Radioterapia Osvaldo Cruz. Rio de Janeiro (RJ), Brasil

DOI:

https://doi.org/10.32635/2176-9745.RBC.1978v28n1.3544

Keywords:

Uterine Cervical Neoplasms/radiotherapy, Ichthyosis, Radiotherapy/adverse effects

Abstract

It is well known today that radiotherapy is the most efficient method of treatment of the carcinoma of the cervix. It is usually accepted aiso that the incidence of some sequels is justifiable as soon as it be kept in the lowest level possible. Trying to find out if this has correlation with the incidence of hypogastrium subcutaneous fibrosis, in the cervix carcinoma treatment, 96 patients treated at Instituto de Radioterapia Osvaldo Cruz were analysed. The incidence of fibrosis was related to treatment technics, tumor dose and TDF factor. The results indicated that TDF factor is the only one that can be directiy related to the incidence of this sequeis. The critical value for TDF factor was formed as 110, and any increase on it elevates the fibrosis incidence by a factor of 5. It is recommended finally that the TDF calculation should be utilized as the main factor in the selection of the several parameters envolved in this kind of treatment.

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References

BERGONIE, J. & TRIBONDEAU, L. - Interprétation de quelques resultats de Ia radiothérapie et essai defixationd'unetechnique rationnelle. C. R. Acad. Sci. 143: 983-985, 1906.

BERRY, R.J.JWIERNIK, G. & PATTERSON, T.J.S. — Skin tolerance to fractionated X irradiation in the pig — how good a predictor is the NSD formula? Brit. J. Radiol. 47: 185-190, 1974. DOI: https://doi.org/10.1259/0007-1285-47-555-185

BOTSTEIN, C. - Periodic fractionation of treatment. Progress in Radiation Therapy 2: 84-93, 1962.

BRASIL. MINISTÉRIO DA SAÚDE. (REG.CAN. S. PAULO) — Incidência de câncer no Município de São Paulo, 1969 - 1975.

BRITISH INSTITUTE OF RADIOLOGY Depth dose for use in radiotherapy. Brit. J. Radiol. SuppI. 10, 1961.

BROWN, J.M. & PROBERT, J.C. - Long time recovery of connective tissue after radiation. Radiology 108: 205—207, 1973. DOI: https://doi.org/10.1148/108.1.205

BUCHLER, A.D. & KLINE; J.C. – Radiation reactions in cervical câncer therapy. Amer. J. Obstet. Gynecol. 111: 745-750, 1971. DOI: https://doi.org/10.1016/0002-9378(71)90483-2

BUSCHKE, F. & PARKER, R. Câncer of the female genitalia. In: Radiation Therapy in Cancer Management. New York, Grune &Stratton, 1972, p. 270-293.

CHAU, P.M.; FLETCHER, G.H.; RUTLEDGE, F.N. & DOOD, G.D. — Complications in high whole pélvis irradiation in female pelvic cancer. Am. J. Rozentg. 87: 22-40, 1962.

COLE, M.P. — Radiotherapy for cervical cancer — Radium In: EASSON, E.C., ed. — Cancer of the Uterine Cervix. London, W.B. Saunders Co., 1973, p. 37-52.

COLE, M. P. — Radiotherapy for cervical cancer - X — rays. In: EASSON, E.C., ed. - Cancer of the Uterine Cervix. London, W.B. Saunders, Co., 1973, p. 53-76.

DEELEY, T.J. & HALE, B.T. - The past seventy-five years in radiotherapy. Brit. J. Radiol. 46: 906-909, 1973. DOI: https://doi.org/10.1259/0007-1285-46-550-906

EINHORN, N. - Frequency of severe complication after radiation therapy for cervical carcinoma. Acta Radiol. 14: 42-48, 1975. DOI: https://doi.org/10.3109/02841867509132260

ELLIS, F. — Fractionation and dose rate. Brit. J. Radiol. 36: 153-162, 1963. DOI: https://doi.org/10.1259/0007-1285-36-423-153

ELLIS, F — Dose, time and fractionation. A clinical hypotesis. Clin Radiol. 20: 1—7, 1969. DOI: https://doi.org/10.1016/S0009-9260(69)80043-7

ELLIS, F. - Nominal standard dose and the ret. Brit. J. Radiol. 44: 101—108, 1971. DOI: https://doi.org/10.1259/0007-1285-44-518-101

ELLIS, F.; SORENSEN, A. & LESCRENIER, Radiation therapy schedules for opposing parallel fields and their biological effects. Radiology 111: 701-707, 1974. DOI: https://doi.org/10.1148/111.3.701

FICHARDT; T. & JANSEN, C.R. - Cancer of the cervix uteri. Is there a "best method for its management? Med. Proceedings 16: 247-252, 1970.

FISCHER, J.J. & FISCHER, D.B. – The determination of time dose relationships from clinical data. Brit. J. Radiol. 44: 785-792, 1971. DOI: https://doi.org/10.1259/0007-1285-44-526-785

FLETCHER, G.H. — Squamous cell carcinomas of the uterine cervix. In: Textbook of Radiotherapy. 2nd. Phil, Lea & Febiger, 1973, p. 620-665.

FLETCHER, G.H. & CHASSAGNE, D. - Causes possibles de recto sigmoidites et de sigmoidites survenant après radiotherapie pour câncer du col. J. Radiol. Eletrol. Med. Nucl. 49: 639-641, 1968.

FOWLER, J.F. — Experimental animal results relating to time-dose relationships in radiotherapy and the "ret" concept. Brit. J. Radiol. 44; 81-90, 1971. DOI: https://doi.org/10.1259/0007-1285-44-518-81

FOWLER, J.F. — Dose time relationships in radiotherapy and the validity of cell survival curve models. Brit. J. Radiol. 36: 163-173, 1963. DOI: https://doi.org/10.1259/0007-1285-36-423-163

FRANCIOSI, V.P. - Tumores de colo de útero. Rev. Med. (São Paulo) 53: 139-146, 1969.

FRANCIOSI, V.P. & LEDERMAN, M.V. - Noções físicas de Radioterapia. Rev. Med. (São Paulo) 53: 99-106, 1969.

HAGEMANN, R.F. & CONCANNON, J.P. - Time/dose relationships in abdominal irradiation: a definiton of principies and experimental evaluation. Brit. J. Radiol. 48: 545-555, 1975. DOI: https://doi.org/10.1259/0007-1285-48-571-545

HALL, E.J. — Radiation dose-rate: a factor of importance in radiobiology and radiotherapy. Brit. J. Radiol. 45: 81-97, 1972. DOI: https://doi.org/10.1259/0007-1285-45-530-81

HELLMAN, S. - Cell kinetics, models and cancer treatment. Some principies for the radiation oncologist. Radiology 114: 219-223, 1975. DOI: https://doi.org/10.1148/114.1.219

HENDEE, W.R. - Radiation dose. In: Medical Radiation Physics. Chicago, Year Book Medical Publishers, 1970, p. 169-184.

HEWITT, H. Rationalizing radiotherapy: some historical aspects of the endeavour. Brit. J. Radiol. 46: 917-925, 1973. DOI: https://doi.org/10.1259/0007-1285-46-550-917

JOHNS, H.E. & CUNNINGHAM, J.R. - Radium and radium dosage. In: The Physics of Radiology. 3rd ed., Illinois, Charles C. Thomaz, 1969, p. 471-531.

KALLMAN, R.F. - Methods for the Study of Radiation Effects on Cancer Cells. Manuscripto, 1975, a ser publicado.

KAPLAN H.S. — Radiobiology's contribution to Radiotherapy: Promise or mirage? Failia Memorial Lecture. Radiat. Research 43: 460-476, 1970. DOI: https://doi.org/10.2307/3573049

LAJTHA, L.G. & OLIVER, R. - Some radiobiological considerations in radiotherapy. Brit. J. Radiol. 34: 252-257. 1961. DOI: https://doi.org/10.1259/0007-1285-34-400-252

LEDERMAN, M.V. - Reações orgânicas ao tratamento radioterápico. Rev. Med. (São Paulo) 53: 163-164, 1969.

LEDERMAN, M.V. & VIZEU, D.M. - Installation, operation and maintenance of the L.A. Clinac 4 at Instituto de Radioterapia Osvaldo Cruz. Proc. 19Conf. Latino Americana de Física em Medicina e Proteção Radiológica, São Paulo, 1972.

LEDERMAN, M.V. - Estudo da dose terapêutica equivalente em tratamentos radioterápicos de meduloblastoma. Rev. Bras. Cancerologia 1: 15—40, 1973 (Tese, Fac. Med. USP, 1972).

LEDERMAN, M.V.; BARRETO LINS, J.R.; MONTENEGRO, R.B. & MIOLA, U.J. - Cervix cancer treatment — Coxo femural sequela. Int. J. Radiat. Oncol. Biol. Physics suppi. 1: 144, 1976.

LEE, K.H.; KAGAN, A.R. & NORMAN, A. - Analysis of dose, dose-rate and treatment time on the production of injuries by radium treatment for cancer of the uterine cervix. Brit. J. Radiol. 49: 430—440, 1976. DOI: https://doi.org/10.1259/0007-1285-49-581-430

LITTBRAND, 3. & EDINYR, F.-Preliminary results of bladder carcinoma irradiated with low individual doses and a high total dose. Int. J. Radiat. Oncol. Biol. Physics 1: 1059-1062,1976. DOI: https://doi.org/10.1016/0360-3016(76)90076-6

LIVERSAGE, W.E. - A critical look at the ret. Brit. J. Radiol. 44: 91-100, 1971. DOI: https://doi.org/10.1259/0007-1285-44-518-91

MANTELL, B.S. - The technical aspects of radiotherapy. In: HOPE STONE, H.F. - Radiotherapy in Modem Clinical Practice. London, Crosby Lookwood, 1976, p. 1 -23.

MANZIONE, A. — Retite actínica por irradiação do carcinoma do colo uterino. São Paulo, 1972 (Tese de Doutoramento, FMUSP).

MIOLA, U.J. & VIZEU, D.M. - Construção e uso de um aplicador tipo "Afterloading para o tratamento do câncer do colo de útero. Proc: 2ª Conf. Latino Americana de Física Médica e Proteção Radiológica, Brasil, 1975.

MOSS, W. T.; BRAND, W.N. & BATTIFORA, H. - The cervix in Radiation Oncology, 4th ed. — Saint Louis, C.V. Mosby Co., 1973, p. 408-453.

MOTT, T.J.; MOULD, R.F. & NEWTON, K.A. — Experience in the treatment of carcinoma of the cervix using a rotational technique. Brit. J. Canar. 29: 66-71, 1974. DOI: https://doi.org/10.1038/bjc.1974.8

NAGELL, J.R. Jr.; PARKER, J.C. Jr.; MARUYAMA, Y.; UTLEY, J & LUCKETT, P. — Bladder or rectal injury following radiation therapy for cervical cancer. Amer. J. Obstetr. Gynecol. 119: 727—732, 1974. DOI: https://doi.org/10.1016/0002-9378(74)90082-9

NELSON, J.H. Jr. HOLLAND, J.F. & FREI, E. III. Cancer Medicine. Phil. Lea & FEBIGER, 1973 p. 1733-1743.

NEWMAN, A.; KATSARIS, J. & BLENDIS, L.M. — Small bond injury following pelvic irradiation: A common complication of Radiotherapy. GUT 14: 826, 1973.

NIAS, A.H.W. — Some comparisons of fractionation effects by erythema measurements on human skin. Brit. J. Radiol. 36: 183-187, 1963. DOI: https://doi.org/10.1259/0007-1285-36-423-183

OLIVER, R. - Theoretical implications of cell survival data in relation to fractionated radiotherapy treatments. Brit. J. Radiol. 36: 178-182, 1963. DOI: https://doi.org/10.1259/0007-1285-36-423-178

ORTON, C.G. & ELLIS, F. - A simplification in the use of the NSD concept in practical radiotherapy Brit. J. Radioi. 46: 529—533, 1973. DOI: https://doi.org/10.1259/0007-1285-46-547-529

ORTON, C.G. — Time dose factors (TDFs) in brachytherapy. Brit. J. Radiol. 47: 603-607, 1974. DOI: https://doi.org/10.1259/0007-1285-47-561-603

PATERSON, R. - The uterine cervix. In: The Treatment of Malignant Diseasesby Radiotherapy, 2nd ed, London, Edward Arnolds Publishers, 1963, p. 337—363.

PATERSON, R. - General Principies. In: The treatment of Malignant Diseases by Radiotherapy. 2nd ed, London Edward Arnalds Publishers, 1963, p. 1—18.

REGATO, J.A. — Wilhelm Conrad Roentgen. Int. J. Radiat. Oncol. Biol. Physics 1: 133-139, 1975. DOI: https://doi.org/10.1016/0360-3016(75)90021-8

ROBBINS, S.L. — Lesões por agentes químicos e físicos. In: Patologia. 2ª ed. – Rio de Janeiro, Guanabara Koogan SA, 1969, p. 210-234.

RUBIN. P. & CASARETT, C.W. Radiation histopathology. In: Clinicai Radiation Pathology. Phil. W.B. Saunders Co., 1968. p. 38-62.

RUBIN, P. & CASARETT. C.W. - Skin and adnexa. In: Clinical Radiation Pathology. Phil. W.B. Saunders, Co., 1968, p. 62-120.

RUBIN, P. & CASARETT, C.W. - Radiopathologic basis of the modification of radiation response. In: Clinicai Radiation Pathology. Phil. W.B. Saunders, Co., 1968, p. 894-934.

RUBIN, P. & PULTER. C. - Principies of radiation oncology and cancer radiotherapy. In: RUBIN, P. - Clinical Oncology for Medical Students and Physicians. 4fh ed N. York of Rochester, 1974, p. 66-87.

RUDOLPH, J. — Cancer of the female genital tract. In: RUBIN, P. Clinical Oncology for Medical Students and General Physicians. 4th ed. N. York, Univ. of Rochester, 1974, p. 217-230.

RUSSEL, J.G.B. & RICHARDS, B. - A review of pelvimetry data. Brit. J. Radiol. 44: 780-784, 1971. DOI: https://doi.org/10.1259/0007-1285-44-526-780

RUTLEDGE, F.N. & FLETCHER, G.H. - The role of surgery in irradiation therapy for cervical cancer. In: FLETCHER, G.H. — Textbook of Radiotherapy. Phil. Lea & Febiger, 1966, p. 474-484.

SAMBROOK, D.K. Clinical aspects of fractionation and dose time relationships. Brit. J. Radiol. 36: 174-177, 1963. DOI: https://doi.org/10.1259/0007-1285-36-423-174

SAMPAIO GOES Jr. J. — O problema do cancer de útero no Brasil. MIN. SAÚDE — Cancer of the Uterus in Developing Areas. Brasil, Editora do Min. Saúde, 1973, p. 49-58.

SÃO PAULO, FAC. MEDICINA - Manual de Regulamentos e Rotinas. CLINICA GINECOLÓGICA DO DEPTO. OBST. GINECOLOGIA., São Paulo, Hospital das Clínicas, 1975.

SPALTHOLZ, W. — Músculos Abdominais. In: Atlas de Anatomia Humana. R. Janeiro. — Guanabara Koogan S.A. 1956, fig. 144-a 145-146.

STRANDQUIST, M. - Studien ueber die kumulative wirkung den Roentgenstrahien bei Fraktionierung. Acta Radiol. suppl. 55: 1-300, 1944.

TURESSON, I & NOTTER, C. - Skin reactions after different fractionation schedulles giving the same cumulative radiation effect. Acta Radiol. 14: 475-484, 1975. DOI: https://doi.org/10.3109/02841867509132688

U.I.C.C. - TNM Classification of Malignant Tumours, 2nd. Genève, 1974.

U.K. — The Hospital Physicist Association. A code of practice for the dosimetry of 2 to 35 MV X-rays and Caesium—137 and Cobalt—60 Gamma-ray beam. Phys. Med. Biol. 1: 1-8, 1969. DOI: https://doi.org/10.1088/0031-9155/14/1/001

U.S.A. — Research Plan for Radiation Therapy. Comittee for Radiation Oncology Studies. A.C.R. 1975.

U.S.A. — Clinical Staging for Carcinoma of the Uterus. American Joint Committee for Cancer Staging and End Results Reporting, Washington, 1972.

VIZEU, D.M. — Simuladores em Radioterapia. Um luxo ou uma necessidade? Rev. Assoc. Bras. Físicas em Medicina. 13: 3-5. 1976.

WANG, C.C. & DOPPKE, K. - Osteoradionecrosis of the temporal bone. Consideration of Nominal Standard Dose. Int. J. Radiol. Oncol. Biol. Phisies 1: 881-884, 1976. DOI: https://doi.org/10.1016/0360-3016(76)90112-7

WILSON, C.S. & HALL, E.J. - On the advisability of treating all fields at each radiotherapy session. Radiology 98: 419-423, 1971. DOI: https://doi.org/10.1148/98.2.419

Published

2023-08-11

How to Cite

1.
Laderman MV. Radiotherapy of Cancer of the Cervix Utery - Occurrence of Actinic Fibrosis in the Subcutaneous Tissue. Rev. Bras. Cancerol. [Internet]. 2023 Aug. 11 [cited 2024 Jul. 22];28(1):5-38. Available from: https://rbc.inca.gov.br/index.php/revista/article/view/3544

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ORIGINAL ARTICLE