Um Estudo Experimental Sôbre a Dinâmica da Regeneração Hepática
DOI:
https://doi.org/10.32635/2176-9745.RBC.1964v20n27.3743Keywords:
Liver Regeneration, Liver Regeneration/physiology, PoisoningAbstract
The Author makes preliminary considerations on the liver architecture according to the ideas presented by Rappaport and points out the functional differences observed between the two zones of the liver acinus. To demonstrate the truth of these propositions the thioacetamide intoxication has been studied in its morphological and dynamic aspects. The Author also studies and discuss the influence of the endocrine imbalance upon the liver regeneration and concludes by making the suggestion that the stimulus that initiates regeneration in the liver might well be the relative excess of circulating hormones and metabolites that follows a partial hepatectomy or a damage to the liver parenchyma.
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ELIAS, H. — Re-examination of the structure of the mammalian liver. I. Parenchymal Architecture. Am. J. Anat. 84; 311,1949. DOI: https://doi.org/10.1002/aja.1000840206
ELIAS, H. — The structure of the live of vertebrates. Acta Anat. 14: 297, 1952. DOI: https://doi.org/10.1159/000140715
RAPPAPORT, A. M. — “The structural and functional acinar unit of the liver; some histopathological considerations”. Hepatitis Frontiers, Little Brown, Co., 1957.
RAPPAPORT, A. M. — The Structural and functional unit in the human liver (liver acinus). The Anatomical Record, 130; 673, 1958. DOI: https://doi.org/10.1002/ar.1091300405
RAPPAPORT, A. M. e HIRAKI, G. Y. — Histopathologic changes in the structural and functional unit of the human liver. Acta Anatômica, 32; 240, 1958. DOI: https://doi.org/10.1159/000141326
RAPPAPORT, A. M. e HIRAKI, G. Y.— The anatomical pattern of lesions in the liver. Acta Anatômica, 32: 126, 1958. DOI: https://doi.org/10.1159/000141318
WACHENSTEIN, M. — Enzymatic histochemistry of the liver. Gastroenterology, 37: 525, 1959. DOI: https://doi.org/10.1016/S0016-5085(19)35357-0
NOVIKOFF, A. B. — The biochemical cytology of liver. Bulletin of the New York Academy of Medecine, 35: 67, 1958.
NOVIKOFF, A. B. e ESSNER, E. — The liver cell. The American Journal of Medicine, 29: 102, 1960. DOI: https://doi.org/10.1016/0002-9343(60)90011-5
WEINBREN, K. the liver. Regeneration of the liver Gastroenterology, 37; 657, 1959. DOI: https://doi.org/10.1016/S0016-5085(19)35367-3
BUCHER, N. R. L.; SCOTT, J. F. e AUB, J. C. — Regeneration of liver in parabiotic rats. Cancer Res., 11: 457, 1951.
FBIEDRICH-FREKSA, H. e ZAKI, F. G. — Spezifische Mitose-Auslosung in normaler ratten-Leber duch von partieel hepatectomierten ratten Zeit-schrift fur Naturforschung, 9b; 394, 1954. DOI: https://doi.org/10.1515/znb-1954-0603
ADIBI, S. K.; PASCHKIS, E. e CANTAROW, A. — Stimulation of liver mitosis by blood serum from hepatectomized rats. Exptl. Cell Res., 18; 396, 1959. DOI: https://doi.org/10.1016/0014-4827(59)90024-2
GLINOS, A. D. e GEY, G. O. — Hormonal factors involved in the induction of liver regeneration in the rat. Proc. Soc. Exp. Biol. Med., 80: 421, 1952. DOI: https://doi.org/10.3181/00379727-80-19643
GLINOS, A. D. Evidence for a negative feed-back system controling liver regeneration. Symposium on Information Theory in Biology, Pergamon Press, 1956.
GLINOS, A. D. — Environmental feedback control of cell division. Annals of the New York Academy of Sciences, 90: 592, 1960. DOI: https://doi.org/10.1111/j.1749-6632.1960.tb23275.x
KELLY, L.; HIRSCH, J. D.; BEACH, G. e PALMER, W. — The time function of P 32 incorporation into DNA of regenerating liver: the effect of irradiation. Câncer Res., 17: 117, 1957. DOI: https://doi.org/10.2172/4343660
CASPERSSON, T.; KLEIN, E. e Ringertz, N. R. — Cytochemical studies on some effects of X-radiation on three ascites tumors. Câncer Res., 18: 857, 1958.
WILLIAMS, R. B.; TO AL, J. N.; WHITE, J. e CARPENTER, H. M. — The effect of total-body x-radiations from near threashold to tissue lethal doses on the small bowell epithelium of the rat. Research Repport. NM 6202000201. Naval Medical Research Institute, Bethesda, Marynland.
TOAL, J. N.; REICH, J. C.; WILLIAMS, R. B. e WHITE, J. — Effect of totalbody x-irradiation from near threa shold to tissue lethal doses on the small bowell epithelium of the rat. Research Repport. NM 6202000202. Naval Medical Research Inst., Bethesda, Marynland.
DUCOFF, H. S. e EHRET, C. F. — Mitogenesis. The University of Chicago Press, 1956.
PRESCOT, D. M. — Relation between cell growth and cell division. IV. The synthesis of DNA, RNA and protein from division to division in Tetrahymema. Exptl. Cell Res., 19: 228, 1960 DOI: https://doi.org/10.1016/0014-4827(60)90004-5
GELFANT, S. — Initiation of mitosis in relation to the cell division cycle. Exptl. Cell Res., 26: 395, 1962. DOI: https://doi.org/10.1016/0014-4827(62)90191-X
PUCK, T. T. e MARCUS, P. I. — Action of x-rays on mammalian cells. J. Exper. Med., 103: 653, 1956. DOI: https://doi.org/10.1084/jem.103.5.653
TOLMACH, L. J. e MARCUS, P. I. — Development of x-ray induced giant Hela cells. Exptl. Cell Res., 20: 350, 1960. DOI: https://doi.org/10.1016/0014-4827(60)90163-4
SHEEK, M. R.; DESARMIER, R. M; SAGIK, B. P. e MAGEE, W. E. — Biochemical changes during the formation and growth of giant cells from irradiated Hela cells. Exptl. Cell Res., 19: 549, 1960. DOI: https://doi.org/10.1016/0014-4827(60)90063-X
MAC DONALD, R. A. e ROGERS, A. E. — Lack of effect of plasma from partially hepatectomized cirrhotic and normal rats on deoxyribonucleic acid synthesis and mitosis in rat liver. Gastroenterology, 41: 33, 1961.
ROGERS, A. E.; SHAKA, J. A.; PECHET G. e MAC DONALD, R. A. — Absence of a “humoral factor” affecting hepatic regeneration in parabiotic rats. Am. J. Path., 39: 561, 1961.
ALSTON, W. C. e THOMSON, R. Y. — Humoral and local factors in liver regeneration. Câncer Res., 23: 901. 1963.
FISHER, B.; FISHER, E. R. e SAFFER, E. Investigation concerning the role of a humoral factor in liver regeneration. Câncer Res., 23: 914, 1963
VAN POTTER, R. e AUERBACH, V. H Adaptive enzyme and feed-back mechanism. Lab. Investigat, 8: 495, 1959.
SCHAPIRA, F. — L’adaptation enzymatique chez les animaux superieurs. Revue Françoise cl’etudes cliniques ct biologiques, 5: 722, 1960.
QUASTLER, H. — Chemical communication Systems in the cell. Transactions of the New York Academy of Sciences, 25: 382, 1963. DOI: https://doi.org/10.1111/j.2164-0947.1963.tb01462.x
PITOT, H. C. e HEIDELBERGER, C. — Metabolic regulatory circuits and carcinogenesis. Cancer Res., 23: 1694, 1933
SWARTZ, F., SAMS, B. F. e BARTON. A. G. — Polyploidization of rat liver following castration of males and females. Exptl. Cell Res., 20: 438, 1930. DOI: https://doi.org/10.1016/0014-4827(60)90172-5
CHILDS, J. F. L. e SIEGLER, E. A. — Controlling orange decay. Industrial and Eng. Chem., 38: 82, 1346. DOI: https://doi.org/10.1021/ie50433a034
FITZHUGH O. G. e NIELSCN A. A. — Liver tumors in rats fed thiourea and thioacetamide. Science, 108: 626, 1948. DOI: https://doi.org/10.1126/science.108.2814.626
AMBROSE, A. M., DEEDS, F. e RATHER, L. J. — Toxicity of thioacetamide in rats. J. Industr. Higi. a Toxicol., 31: 158, 1949.
RATHER, L. J. — Experimental alteration of nuclear and cytoplasrnic componentes of the liver cell with thioacetamide. Bull. Johns Hopkins Hosp., 88: 38, 1951.
CARNES, W. H., BERNSTEIN, D. S. e RATHER, L. J. — Effect of thioacetamide on the desoxiribonucleic contente of liver cells. Federation Proc., 12: 385, 1953.
LAIRD, A. K. Nuclear changes induced in rat liver cells by thioacetamide. Arch. Biochem. and Biophysics, 46: 119, 1953. DOI: https://doi.org/10.1016/0003-9861(53)90175-1
NYGAARD, O., ELDJARN, L, e NAKKEN, K. F. — Studies on the metabolims of. thioacetamide — S35 in the intact rat. Cancer Res., 14: 625, 1954.
HEIZER, P. — Desoribose nucleic acid (DNA) content size and size of rat liver nuclei during thioacetamide intoxication and recovery. Chromossoma Band. 7: 281, 1955, DOI: https://doi.org/10.1007/BF00329729
GUPTA, D. N. — Production of cancer of the bile ducts with thioacetamide. Nature, 175: 257, 1955. DOI: https://doi.org/10.1038/175257a0
GUPTA, D. N. — Acute changes in the liver after administration of thioacetamide. J. Path. Bact. 72: 1953.
GUPTA, D. N. — Nodular cirrhosis and metastasizing tumors produced in the liver of the rats by prolonged feeding with thioacetamide. J. Path. Bact. 72: 415, 1956. DOI: https://doi.org/10.1002/path.1700720207
GALLAGHER, C. H., GUPTA, D. N., JUDAH, J. D. e REES, K. R. — Biochemical changes in liver in acute thioacetamide intoxication, J. Path. Bact., 72: 193, 1956. DOI: https://doi.org/10.1002/path.1700720125
KLEINFELD, R. G. — Early changes in rat. liver and kidney cells induced by thioacetamide. Câncer Res. 17: 954. 1957.
KLEINFELD, R. G. e HAAM, E. Von — The effect of thioacetamide on rat liver regeneration. I. Citolgical studies. Cancer Res., 19: 769, 1959.
KLEINFELD, R. G. HANN, E. Von — Effect of thioacetamide on rat liver regeneration. II. Nuclear RNA in mitosis, J. Biofhysic and Biochem Cytol, 6: 393, 1959. DOI: https://doi.org/10.1083/jcb.6.3.393
GRANT H. C. e REES, V. R. — The precancerous liver correlation of histological and histochemical changes in rats during prolonged administration of thioacetamide and butter yellow Proceedings of the Royal Society, 148: 930, 1958. DOI: https://doi.org/10.1098/rspb.1958.0010
BAKER, E. A., SMUCKLER, E. A. c BENDITT, E. P. —- Effect of thioacetamide and yellow phosphorus poisoning on protein synthesis in vivo. Lab. Investigat., 12: 995, 1963.
ADAMS, H. R. e BUSOH, H. — Effects of thioacetamide on incorporation of orotic acid-2-Ci4 into RNA fractions in liver. Câncer Research, 23: 576, 1963.
MURAMATSU, M. e BUSCH, H. — Effects of thioacetamide on metabolism of proteins of normal and regenerating liver. Câncer Res., 22: 1100, 1962.
SULKIN, N. M. A study of the nucleus in the normal and hyperplastic liver of the rat. Am. J. Anat., 73: 107, 1943. DOI: https://doi.org/10.1002/aja.1000730106
PCST, J., HIMES, M. B., KLEIN, A, e HOFFMAN, J. — Responses of liver to injury. Arch. Path., 64: 278, 1957.
HARKNESS, R. D. The spatial distribution of dividing cells in the liver of the rat after partial hepatectomy. J. Physiol., 116: 373, 1953. DOI: https://doi.org/10.1113/jphysiol.1952.sp004711
HARTROFT, W. S. — “Experimental hepatic injury” in Diseases of the liver. J. B. Lippincott Co., 1956.
MACKAY, E. M. e BARNES, R. H. — Choline and pancrea extract on fatty livers and ketosis due to anterior pituitary extract. Proc. Soc. Exper. Biol. Med., 38: 803, 1938. DOI: https://doi.org/10.3181/00379727-38-10022
SHIPLEY, R. A., CHADZIK, E. B. e GYORGY, P. Effect of extirpation of various giands ond production of fatty liver. Arch. Biochem., 16: 301. 1948.
EMERSON, W. J., ZANNARIK, P. C. e NATHANSON, I. T. — The effect of sex hormones on hepatic and renal lesions. Endodrinology, 48: 548, 1951. DOI: https://doi.org/10.1210/endo-48-5-548
HANDLER, P. e FOLLIS, R. H. — Role of thyroid activity in the pathogenesis of hepatic lesion due to choline and cystine deficiency. J. Nutrition, 35. 669, 1948. DOI: https://doi.org/10.1093/jn/35.6.669
TANNENBERG, J. Pathological changes in the heart, skeletal muscle and liver in rabbits treated with insulin in shock dosage. Am. J. Path., 15: 25, 1939.
DEANE, H. W. e GREEP, R. O. — A morphological and histochemical study of the rat adrenal cortex after hypophysectomy with comments on the liver. Am. J. Anat., 79: 117, 1946. DOI: https://doi.org/10.1002/aja.1000790104
DRABKIN, D. L, — Liver regeneration and cytochrome metabolism. J. Bioal. Chem., 171: 395, 1947. DOI: https://doi.org/10.1016/S0021-9258(17)41138-0
VESTLING, C. S. e KNOEPPELMACHER, A. A. — Lactic-dehidrogenase of liver and its relation to thyroide activity in the rat. J. Biol. Biochem., 183: 63, 1950. DOI: https://doi.org/10.1016/S0021-9258(18)56443-7
BIELCHOWSKY, F. — The role of hormonal factors in the development of tumors induced by 2-aminofluorene and related compounds. Acta. Inter, contra Cancrum, XVII: 121, 1961.
GRIFFIN, A. C., RINFRET A. P. e CORSIGLIA, V. F. — The inhibition of liver carcinogenesis with 3-methyl-4-dimethylaminoazobenzene in hypophysectomized rats. Câncer Res., 13: 77, 1953.
SYMEONIDES A., MULAY, A. S. e BURGOYNE, F. H. — Effect of adrenalectomy and of desoxicorticosterone acetate on the formation of liver lesions in rats fed p-dimethylaminoazo-benzene. J. Nat. Câncer Inst., 14: 805, 1954.
HOCH-LIGET, C. Effect of cortisone administration on induced and transplanted hepatomas. J. Nat. Cancer Inst., 15: 19663, 1955.
BIELCHOWSKY, F. e HALL, W. H. — Inhibition of the hepatoma inducing action of 2-amino and 2-acetylamino-fluorene by thyroidectomy. Proc. Univ. Otago med.'sch., 30: 26, 1952.
MILLER, W. L. e BAUMAN, C. A. — Basal metabolic rate and' liver tumors dué to'‘'azo-dyes. Cafícér Res., 11: 634, 1951.
RUMSFELD, H. W., MILLER, W. L. e BAUMAN, C. A. — A sex diference ih the development of livers tumors in rats fed 3-methyl-4-dymethylaminoa-zobenzene of 4-flüoro-4-dimethylami-noazobenzene. Câncer Res., 11: 814, 1951
LEATHEM,''J. H. — Influence of sex on 2-acetylaminofluorene-induced liver tumors in rats and mice. Câncer Res., 11: 266, 1951.
MORRIS, H. P. DUHNIK, c. s. e JOHNSON, J. M, Studies On the carcinogenic action in the rat of 2-nitro, 2-amino, 2-acetylamino and 2-diacetylaminofluorene after ingestion and after painting. J. Nat. Cancer Inst. 1: 1201, 1950.
FARBER, E., KOCH WESER, D. e POPPER, H. — The influence of sex and testosterone on fatty liver due to ethionine. Endodrinology, 48: 205, 1951. DOI: https://doi.org/10.1210/endo-48-2-205
BIELCHOWSKY, F. e BIELCHOWSKY, M. — Carcinogenesis in the pituitary dwarf mouse. The response to 2-ami-nofluorene. Brit, J. Câncer, 14: 195, 1960. DOI: https://doi.org/10.1038/bjc.1960.23
JACOBY, W. - Uber das rhytmische wachstern der Zelleu durch Verdoppelung ihres volumens. Arch. f. Entwck-lugsmech. d. Organ, 106: 124, 1925. DOI: https://doi.org/10.1007/BF02079531
POGO, A. O. POGO, B. G. T. e CORDERO — FUNNES, J. R. Corelation between desoxiribonucleic acid and volume in liver cells nuclei during potnatal growth. Exptl. Cell. Res., 20: 208. 1960. DOI: https://doi.org/10.1016/0014-4827(60)90237-8
SWARTZ, F. J. — The development in the human liver of multiple deoxiribose nucleic acid (DNA) classes and their relationship to the age of the individual. Chromosoma, 8: 53, 1956. DOI: https://doi.org/10.1007/BF01259493
STENRAM, V. — Nucleolus sizes in the liver of rats fed ou high and non-protein diets after starvation.. Acta Anatômica,,26: 352, 1956 DOI: https://doi.org/10.1159/000141108
--WILSON, J.W- Hepatomâs produced in mice by feeding bentonite in the diet. Annals of the New York Academy of Sciences, 57: 678/ 1954 DOI: https://doi.org/10.1111/j.1749-6632.1954.tb36444.x
FARBER, E. — Similarities in the sequence, of early histological changes induced ,in the liver of the rat by ethionine, 2-acetylaminofluorene, a 3-methyl-4dimmethylaminoazobeno. Cancer Res., 16: 142, 1956.
BULL, L. B. e DICK, A. T. – The chronic pathological effects on the liver of the rato f the pyrolizidine, and their N-oxides. J. Path. Bact.., 78: 483, 1959. DOI: https://doi.org/10.1002/path.1700780215
SCHOENTAL, R. e MAGEE, P. N. – Chronic liver changes in rats after a single dose of lasiocarpine, a pyrrolizidine (senécio) alkaloid. J. Path. Bact. 74; 305, 1957. DOI: https://doi.org/10.1002/path.1700740208
SCHOENTAL, R. e MAGEE, P. N. — Further observation on the subacute and chronic liver changes in rats after a single dose of varius pynolizidine (senécio) alkaloids. J. Path. Bact., 78; 471, 1959. DOI: https://doi.org/10.1002/path.1700780213
GUIMARÃES, J. P. — Lamerton, L. F. e CHRISTENSEN, W. R. — The late effects of thorotrast administration. A review and an experimental study. Brit. J. Câncer, 9; 253, 1955. DOI: https://doi.org/10.1038/bjc.1955.22
GUIMARÃES, J. P., LAMERTON, L. F. — Further observations on the late effects of thorotrast administration Brit. J. Câncer, 9; 527, 1956. DOI: https://doi.org/10.1038/bjc.1956.61
GUIMARÃES, J. P. morfológico dos efeitos do ouro radioativo (Aui98) sôbre o parênquima hepático. O Hospital, 63; 201, 1963.
HAREL, J., GUERIN, M., TUBIANA, J. e ABBATUCCI, J. — Production des tumeurs malignes (hepatomes et autres) par injections Intraperitoniales d’or radioactif chez le rat blanc. Bulletin F.p. etude du câncer, 43; 423, 1956.
CHRISTIE, G. S. e LE PAGE, R. N.— Enlargement of liver cell nuclei; effect of dimethylnitrosamine on size and desoxyribose nucleic acid content. Lab. Investigat. 10; 729, 1961.
ALFERT, M., GESCHWIND, L. I. — The development of polysomaty in rat li ver. Exptl. Cell Res., 15; 230, 1958. DOI: https://doi.org/10.1016/0014-4827(58)90079-X
DISTEFANO, H. S. e DIERMEIER, H. F. — Effects of hypohysectomy and growth hormone on ploidy distribution and mitotic activity of rat liver. Proc. Soc. Exp. Biol. Med., 92; 590, 1956. DOI: https://doi.org/10.3181/00379727-92-22553
CARRIÉRE, R., LEBLOND, C. P. e MESSIER, B. — Increase in the size of liver cell nuclei before mitosis. Exptl. Cell. Res., 23; 625, 1961. DOI: https://doi.org/10.1016/0014-4827(61)90025-8
HIMES, M., HCFFMAN, N. J., POLLISTER, A. W. e POST, J. — Origins of popyploid nuclei in rat liver during regeneration following carbon tetrachloride poisoning. J. Mt. Sinai Hosp., 24; 935, 1957.
GESCHWIND, II., ALFERT, M. e SCHOOLEY, C. Liver regeneration and hepatic polyploidy in the hypophysectomized rat. Exptl. Cell. Res., 15; 232, 1958. DOI: https://doi.org/10.1016/0014-4827(58)90080-6
SPAIN, J. D. — A histochemical study of glycogen alterations in the liver of rats following azo-dye administration. Cancer Res., 17; 3, 1957.