Phospholipids Retard and Cholesterol and Its Derivatives Promote the Formation of Tumors Induced by Carcinogenic Hidrocarbons
DOI:
https://doi.org/10.32635/2176-9745.RBC.1968v24n38.4009Keywords:
Neoplasms/chemically induced, Neoplasms/etiology, Hydrocarbons/toxicity, Phospholipids, CholesterolAbstract
It could be experimentally proved that phospholipids retard and cholesterol and its derivatives promote the formation of tumors induced by carcinogenic hydrocarbons. No sufficient stress can be laid upon the important phenomenon that two very common groups of lipids, i. e. natural components of whatever animal cell, positively influence the mechanism of carcinogenesis. The fact that phospholipids and cholesterol, besides proteins, constitute quantitatively speaking the most important components of cell membranes, led to the logic reasoning that cell surfaces actually do represent a key position in cancer etiology. A series of thusfar ununderstood phenomena can thus be explained satisfactorily.
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ALTMAN, R. F. A.: The origin of the first caneer cell. Arch. Geschwulsforsch., 19; 1 e 97, 1962.
ALTMAN, R. F. A.; A possible definition of the câncer problem. O Hospital, 73: 1525, 1968.
BISCHOFF, F.: Carcinogenesis through cholesterol and derivatives. Progr. Exp. Tumor Res., 3: 412, 1963. DOI: https://doi.org/10.1159/000385969
BISCHOFF, F.: Solid State carcinogenesis (cholesterol-induced). 47th. Ann. Meeting of the Federation of Am. Soc. for Exp. Biology. 1963.
BUNGENBERG DE JONG, H. G. &: BONNER, J.: Phophatide auto-complex coacervates as ionic Systems and their relation to the protoplasmic membrane. Protoplasma, 24; 198, 1935. DOI: https://doi.org/10.1007/BF01605663
CHAPMAN, D.: Biological membranes Academic Press. London & New York, 1968.
DANIELLI, J. F.; Some properties of lipoid films in relation to the structuna of the plasma membrane. J. Cell. Comp. Physiol., 7; 393, 1936. DOI: https://doi.org/10.1002/jcp.1030070307
DAVSON, H. & DANIELLI, J. F.: The permeability of natural membranes. Cambridge Univ. Press. Cambridge, 1943.
DICKENS, F. & WEIL-MALHERBE, H.: Factors afecting carcinogenesis, I. The effect of lipid solvents on tumor production by 3.4-benzpyrene, Câncer Res., 2: 560, 1942.
DICKENS, F. & WEIL-MALHERBE, H.: Factors affecting carcinogenesis. III. The effect of hydrogenation of lipid solvents on carcinogenesis by 3.4-benzpyrene. Cancer Res., 6: 161, 1946.
EMMELOT, P.; BOSS, C. J.; BENEDETTI, E. L. & RÜMKE, P.: Studies on plasma membranes I. Chemical composition and enzyme content of plasma membranes isolated from rat liver. Biochim. Biophys. Acta, 90: 126, 1964. DOI: https://doi.org/10.1016/0304-4165(64)90125-4
FINEAN, J. B.; Phospholipid-cholesterol complexes in the struetUre of myelin. Experientia, 9: 17, 1953. DOI: https://doi.org/10.1007/BF02147697
FINEAN, J. B.: The nature and stability of the plasma membrane. Circulation, 26: 1151, 1962. DOI: https://doi.org/10.1161/01.CIR.26.5.1151
HISGER, I: Carcinogenesis by cholesterol. Brit. J. Câncer, 13: 439, 1959. DOI: https://doi.org/10.1038/bjc.1959.49
HIEGER, I: Cholesterol as carcinogen 1. Sarcoma inductlon by cholesterol in asensitive strain of mince. Brit. J. Câncer, 16: 716, 1962. DOI: https://doi.org/10.1038/bjc.1962.83
HIEGER, I. & ORR. S. F. D.: On the careinogenic aetlvity of purified cholesterol. Brit. J. Cancer, 8: 274, 1964. DOI: https://doi.org/10.1038/bjc.1954.28
Procedings of the Symposium on “Behavlor of lipids at interfaces and in biological membranes”. The American Oil Chemists’ Society at is 30th. Fali Meeting. Cincinnati, Ohio, 1965.
ROFFO, A. H.: Lesiones precancerosas definidas y su relación con la colesterina. Bol. Inst. Med. Exp. del Câncer (Buenos Aires), 3:11, 1926
ROFFO, A. H.: La colesterina segun la edad y su relación con el desarrollo del câncer. Ibid., 3: 195, 1926.
ROFFO, A. H.: Propriedades colesterogeneticas de los tejidos normales y neoplasicos. Ibid., 3; 584, 1926.
ROFFO, A. H.: Relación de la colesterina con el crescimiento de tecidos normales y neoplasicos in vitro. Ibid, 4: 55, 1927.
ROFFO, A. H.: Absorción de la colesterina por el tumor. La colesterina en su passaje por el tejido neoplasico. Ibid. 5: 101, 1928.
ROFFO, A. H. :Influencia de la colesterina sobre el desarrollo dei câncer de alquitrán. Ibid. 6: 144, 1929.
ROFFO, A. H.: La nutrición y el desarrollo de los tumores: Importância de los lipoides. Ibid. 6: 170, 1929.
STEIN, W. D.: The movement of moléculas across cell membranes. Academic Press. London, 1967.
STOECKENIUS, W.: The molecular structure of lipid-water systems and cell membrane models studied wlth the electron microscope. Symp. Intern. Soc. Cell Biology, I: 349, 1961. DOI: https://doi.org/10.1016/B978-1-4832-3079-5.50022-9
STOECKENIUS, W.: Structure of the plasma membrane. An electronmioroscope study. Circulation, 26: 1066, 1962.
Structure and Function of Mem.branes. British Medicai Bulletin, Vo. 24, N.» 2, May, 1968. DOI: https://doi.org/10.1093/oxfordjournals.bmb.a070609
Symposium on the Plasma Membrane. Circulation, Vol. 26, N.o 5, Part. 2. November, 1962. DOI: https://doi.org/10.1161/01.CIR.26.5.1066
SZPSENWOL, J.: Carcinogenic effect of egg whita, egg yolk and lipids in mice. Proc. Soc. Exp. Biol„ 112: 1073, 1963. DOI: https://doi.org/10.3181/00379727-112-28254
SZEPSENWOL, J.: The carcinogenic effect of alcohol extract of egg yolk in mice. 47th. Ann. Meeting of the Federation of Am. Soc. Exp. Biol., 1983; (c. BioL Abtst. 43 (4), Entry no 14.726, 1963).
WEIL-MALHERBE, H. & DICKENS, F.: Factors affecting carcinogenesis II. Incorporation of 3.4-benzypyrene in media containing puriíied licithin or cephalin. Câncer Res, 4; 425, 1944.
WEIL-MALHERBE, H. & DICKENS, F.: Factors affecting carcinogenesis IV. The effect of tricaprylin Solutions of cholesterol and phospholipins. Câncer Res., 6: 171, 1946.
WILMER, E. N.: Stroids and cell surfaces. Biol. Rev., 36: 1961. DOI: https://doi.org/10.1111/j.1469-185X.1961.tb01295.x
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