Poorly Differentiated Large Cell Neuroendocrine Carcinoma of the Transverse Colon: Case Report
DOI:
https://doi.org/10.32635/2176-9745.RBC.2024v70n3.4725Keywords:
Neoplasm Metastasis, Colon, Transverse/pathology, Liver Neoplasms, Neuroendocrine Carcinoma, Abdominal PainAbstract
Introduction: Neuroendocrine carcinomas (NECs) of the colon and rectum are extremely rare malignant subtypes of neuroendocrine tumors, with a reported incidence of 0.1% to 3.9% of all colorectal malignancies. Large cell neuroendocrine carcinomas of the colon (LCNECs) are even rarer, aggressive in nature and have a poor prognosis due to their tendency to early metastasis. Case report: Large cell neuroendocrine carcinoma in the transverse colon with liver metastasis of a 66 years- old male patient, who reported cramping abdominal pain for two months, weight loss of 12 kilos and melena during this period. Abdominal tomography showing circumferential parietal thickening with an infiltrative and stenosing appearance in the transverse colon on the right and multiple hypovascular solid hepatic nodules. Pathology of the lesion compatible with poorly differentiated carcinoma and liver metastases was metastatic adenocarcinoma. Material from the colon biopsy and liver lesions were sent for immunohistochemical studies confirming the diagnosis of high-grade neuroendocrine carcinoma. Conclusion: Early detection can offer a better prognosis for other patients and correct diagnosis is of great importance, as they are often misdiagnosed as adenocarcinoma or another malignant tumor on first imaging or histological study.
Downloads
References
Corbett V, Arnold S, Anthony L, et al. Management of large cell neuroendocrine carcinoma. Front Oncol. 2021;11(653162):1-20. doi: https://doi.org/10.3389/fonc.2021.653162 DOI: https://doi.org/10.3389/fonc.2021.653162
Alloucha A, Moussa MK, Dirany A, et al. Large cell neuroendocrine carcinoma of the colon with brain metastasis: a case report. Int J Surg Case Rep. 2020;76:421-4. doi: https://doi.org/10.1016%2Fj.ijscr.2020.10.015 DOI: https://doi.org/10.1016/j.ijscr.2020.10.015
Tejero-Pintor FJ, Sarmentero-Prieto JC, Bailón-Cuadrado M, et al. Doble metástasis hepática de doble neoplasia de colon: adenocarcinoma y tumor neuroendocrino. Gastroenterol Hepatol. 2019;42:624-5. doi: https://doi.org/10.1016/j.gastrohep.2019.05.004 DOI: https://doi.org/10.1016/j.gastrohep.2019.05.004
Pascarella MR, McCloskey D, Jenab-Wolcott J, et al. Large cell neuroendocrine carcinoma of the colon: a rare and aggressive tumor. J Gastrointest Oncol. 2011;2:250-3. doi: https://doi.org/10.3978/j.issn.2078-6891.2011.026
Felux K, McCarty B, Turner D, et al. Poorly differentiated large cell neuroendocrine carcinoma of the colon: a case report. Cureus.14(1):e20949. doi: https://doi.org/10.7759/cureus.20949 DOI: https://doi.org/10.7759/cureus.20949
Stoner P, Ghaffaripour T, Cohen D. Aggressive large-cell neuroendocrine carcinoma of the sigmoid colon in a patient with ulcerative colitis. BMJ Case Rep. 2017;2017:bcr2017220093. doi: https://doi.org/10.1136/bcr-2017-220093 DOI: https://doi.org/10.1136/bcr-2017-220093
Goksoy B, Tosun Y, Gunay MO. Multifocal diffuse large cell neuroendocrine carcinoma of the colon. J Clin Transl Res. 2022;8(4):272-5.
Khanna V, Reddy T, Nagar T, et al. Metastatic large cell neuroendocrine carcinoma of the colon: a case report. Cureus. 14(6):e26075. doi: https://doi.org/10.7759/cureus.26075 DOI: https://doi.org/10.7759/cureus.26075
Cha JW, Yang M, Mo A. Large cell neuroendocrine carcinoma in the unusual location of the descending colon. Radiol Case Rep. 2020;15(10):1841-4. doi: https://doi.org/10.1016/j.radcr.2020.07.045 DOI: https://doi.org/10.1016/j.radcr.2020.07.045
Bloom JR, Brickman A, Yang FJ, et al. Neuroendocrine carcinoma of the colon presenting as acute meningitis. BMC Neurol. 2019;19(76):1-4. doi: https://doi.org/10.1186/s12883-019-1310-x DOI: https://doi.org/10.1186/s12883-019-1310-x
Parra-Medina R, Moreno-Lucero P, Jimenez-Moreno J, et al. Neuroendocrine neoplasms of gastrointestinal tract and secondary primary synchronous tumors: a systematic review of case reports. casualty or causality? PLoS One. 2019;14(5):1-16. https://doi.org/10.1371/journal.pone.0216647 DOI: https://doi.org/10.1371/journal.pone.0216647
Conselho Nacional de Saúde (BR). Resolução n° 466, de 12 de dezembro de 2012. Aprova as diretrizes e normas regulamentadoras de pesquisas envolvendo seres humanos. Diário Oficial da União, Brasília, DF. 2013 jun 13; Seção I:59.
Lancellotti F, Solinas L, Telesco D, et al. A rare case of metachronous neuroendocrine tumor after a colorectal adenocarcinoma: qualitative critical review of synchronous and metachronous gastrointestinal NET. Clin J Gastroenterol. 2021;14:115-22. doi: https://doi.org/10.1007/s12328-020-01255-9. DOI: https://doi.org/10.1007/s12328-020-01255-9
Woischke C, Jung P, Jung A, et al. Mixed large cell neuroendocrine carcinoma and squamous cell carcinoma of the colon: detailed molecular characterisation of two cases indicates a distinct colorectal cancer Entity. J Pathol Clin Res. 2021;7:75-85. doi: https://doi.org/10.1002/cjp2.183 DOI: https://doi.org/10.1002/cjp2.183
Yoshida T, Kamimura K, Hosaka K, et al. Colorectal neuroendocrine carcinoma: a case report and review of the literature. World J Clin Cases. 2019;7(14):1865-75. doi: https://doi.org/10.12998/wjcc.v7.i14.1865 DOI: https://doi.org/10.12998/wjcc.v7.i14.1865
Published
How to Cite
Issue
Section
License
Os direitos morais e intelectuais dos artigos pertencem aos respectivos autores, que concedem à RBC o direito de publicação.
This work is licensed under a Creative Commons Attribution 4.0 International License.
