Treatment of differentiated carcinoma of thyroid gland with surgery and adjuvante Radioiodine- 131
DOI:
https://doi.org/10.32635/2176-9745.RBC.1996v42n4.2901Keywords:
Differentiated Thyroid Carcinoma, Thyroidectomy, Adjuvant Radioiodine- 131 TreatmentAbstract
Aim: To analyse the results of differentiated thyroid cancer treatment by surgery and adjunctive radioiodine- 131. Material and methods: We analysed retrospectively 96 patients, from 1978 to 1993, with median age of 4l. 7 ± 15.0 years old (SD = 1), inciuding 86fema1es and with median time follow-up of 5.3 ± 4.0 years (SD = 1); they corresponded to 50 cases of papillary carcinoma (PC), 40 cases of follicular carcinoma (FC) and six cases of Hurthle cells (HC). These cases were divided in two groups: A. 81 cases (47PC, 28FC and 6HC) treated by thyroidectomy and complemental radioiodine; B. 15 cases (3PC and I2FC) treated by thyroidectomy and radíoiodine to metastases, the study groups were analysed by age: less than 50 years old (72 cases) and more than 50 years old (24 cases), survival time and associated diseases. Results: Group A showed one death (1.21%) and three cases (3.65%) of metastases in progression, Group B, five deaths (33.33%) andfive (33.33%) of metastases in progression. In patients less than 50 years old, mortality was 4.16% and metastases in progression = 5.55%; above 50 years old, the proportion were 12.5% and 16.66% respectively. All deaths and majority of distant metastases in progression occurred within 10 years of treatment. Nodular autonomous goitre was associated in seven cases (7.29%). General mortality and metastases in progression rates were 6.25% and 8.33% respectively, with all deaths and the most of distant metastases in progression being due to follicular carcinoma. Conclusions: 1. Total thyroidectomy and ablation of residual thyroid tissue with radioiodine may yeald the best results and be more safe. 2. Above 50 years of age the tumor has more aggressive evolution. 3. The highest incidence of mortality and distant progressive disease occurred within 10 years of treatment. 4. Follicular carcinoma must considered as prognostic factor of risk. 5. The association with nodular autonomous goitre is more common than usually thought considered.
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