Estudo de Fase II do Uso da Associação de Interferon Alfa e Isotretinoína no Tratamento de Tumores Sólidos Avançados
DOI:
https://doi.org/10.32635/2176-9745.RBC.1995v41n1.2911Keywords:
Interferon, Retinoic Acid, Cervical Cancer, Head and Neck Cancer, Kaposi's SarcomaAbstract
Some pre-clinical and clinical data support the efficacy and synergism of the combination of retinoids and interferons in the treatment of several so!id tumors. In this prospective phase II trial, thirty patients with advanced and refractoty so!id fumors received interferon alpha-2a, 6 MU/m2 subcutaneously dailay, 5 days a week and 13-cis-retinoic acid, 1 mg/kg orally, daily, for at Ieast 2 months, depending on the response or toxicity. Eighteen had squamous cell cervical carcinoma; 6, squamous cell carcinoma of head and neck; 5, Kaposi'sarcoma already refractory to interferon therapy and 1, xeroderma pigmentosum and several basaloid and squamous cell carcinoma of the skin. There were 5 (16.6%) objective responses, includíng 4 partial responders and 1 complete responder. Additionally, there were 4 disease stabilization. No patient with Kaposi's sarcoma has responded. Median time to progression was 6 months (range 3-11). Toxicity was very mild and mana geable, including Iow fever, fatigue, dry skin and mialgia. These results are encouraging and the use of such a combination as an initial treatment of squamous cell tumors, mainly in neoadjuvant setting is warranted
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