Metástases ósseas: opções de tratamento sistêmico
DOI:
https://doi.org/10.32635/2176-9745.RBC.1995v41n2.2932Palavras-chave:
Metástases Ósseas, Tratamento Sistêmico, Radioisótopos, Nitrato De Gálio, BifosfonatosResumo
As metástases ósseas podem ser um dos primeiros indicativos de doença disseminada nos pacientes com câncer, principalmente de mama, pulmão e próstata. Embora a maior parte desses pacientes tenha sua sobrevida diminuída após o diagnóstico de doença metastática, uma proporção considerável sobreviverá por um período de tempo suficientemente grande para que a doença óssea provoque sintomas significativos, causando dor e afetando a qualidade de vida do indivíduo. Alternativas de tratamento vêm sendo pesquisadas para esses pacientes, em tentativas de interferência no processo fisiopatológico da doença óssea. Radioisótopos e agentes sem atividade citotóxica têm se destacado neste aspecto, e este artigo sobrepassa as diversas alternativas terapêuticas em investigação clínica para esse grupo de pacientes.
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