Resistência a múltiplas drogas: um problema da clínica oncológica com solução na pesquisa básica

Autores

  • Ludmila S. Medina da Cunha Departamento de Clínica Médica. Universidade estadual de Campinas (UNICAMP). Campinas (SP), Brasil.
  • Fernando Medina da Cunha Departamento de Clínica Médica. Universidade estadual de Campinas (UNICAMP). Campinas (SP), Brasil.
  • Mary da Silva Thereza Departamento de Clínica Médica. Universidade estadual de Campinas (UNICAMP). Campinas (SP), Brasil.
  • Regina A. Martinho Departamento de Clínica Médica. Universidade estadual de Campinas (UNICAMP). Campinas (SP), Brasil.
  • André Augusto Jr. G. Moraes Departamento de Clínica Médica. Universidade estadual de Campinas (UNICAMP). Campinas (SP), Brasil.
  • Ricardo Lima Zoliner Departamento de Clínica Médica. Universidade estadual de Campinas (UNICAMP). Campinas (SP), Brasil.

DOI:

https://doi.org/10.32635/2176-9745.RBC.1991v37n1/4.3110

Palavras-chave:

Quimioterapia, Resistência a Múltiplas Drogas

Resumo

A resistência que as células neoplásicas apresentam aos agentes quimioterápicos sempre é um grande problema para o oncologista clínico. A descoberta da glicoproteína (170 Pgp) responsável pela resistência a múltiplas drogas (MDR) abriu novas perspectivas de se superar este difícil tipo de resistência. Neste trabalho, apresentamos uma retrospectiva do trabalho de pesquisa realizado até a definição do modelo que hoje rege os trabalhos clínicos no emprego de agentes reversores da MDR.

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Publicado

2023-07-26

Como Citar

1.
Cunha LSM da, Cunha FM da, Thereza M da S, Martinho RA, Moraes AAJG, Zoliner RL. Resistência a múltiplas drogas: um problema da clínica oncológica com solução na pesquisa básica. Rev. Bras. Cancerol. [Internet]. 26º de julho de 2023 [citado 17º de maio de 2024];37(1/4):51-5. Disponível em: https://rbc.inca.gov.br/index.php/revista/article/view/3110

Edição

v. 37 n. 1/4 (1991): jan./dez.

Seção

ARTIGO ORIGINAL

Licença

Creative Commons License
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

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