Espectro de Atividade NK em um Pequeno Grupo Populacional Brasileiro
DOI:
https://doi.org/10.32635/2176-9745.RBC.1988v34n1.3151Palavras-chave:
Atividade NK, População NormalResumo
Um painel de atividade NK nos indivíduos normais de nossa população foi obtido através da realização de 221 ensaios em 40 indivíduos, sendo 26 do sexo masculino e 14 do sexo feminino; um padrão próprio de atividade NK para as pessoas testadas com maior freqüência foi encontrado, apesar da grande variabilidade intra-individual. Não foi encontrada diferença significativa entre a atividade NK de homens e mulheres e entre as diversas faixas etárias, sendo a literatura controversa em relação a esses parâmetros. Apesar do pequeno número de indivíduos testados, nossos dados coincidem com os obtidos de populações norte-americanas. A semelhança dos resultados apresentados pode decorrer do fato de a maioria de nossa amostra ser extraída de um padrão sócio-econômico elevado, não apresentando problemas de desnutrição, embora envolvesse pessoas de diferentes origens étnicas.
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Takasugi M, Míckey MR, Terasaki TI — Reactivity of lymphocytes from normal persons on cultured tumor cells. Cancer Res. 1973; 33: 3898-3902.
Kiesiling R, Klein E, Wigzeil H — 'Natural' killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype. Eur J Immunol, 1975: 5: 112-117. DOI: https://doi.org/10.1002/eji.1830050208
Weish RM, Hallenbeck LA — Effect of virus infections on target cell susceptibility to natural killer cell-mediated lysis. J Immunol. 1980; 124: 2491-2497. DOI: https://doi.org/10.4049/jimmunol.124.5.2491
Kirk patrick CE, Farrel JP — Splenic natural killer-cell activity in mice infected with Leishmania donovani. Cell Immunol. 1984; 85: 201-214. DOI: https://doi.org/10.1016/0008-8749(84)90290-9
Wiltrout RH, Herberman RB,Zhang S, Chirigos MA, Ortaldo JR, Green KM, Talmadge JE — Role of organ-associated NK cells in the decreased tormation of experimental metastases in lung and liver. J Immunol. 1985; 134: 4267-4275. DOI: https://doi.org/10.4049/jimmunol.134.6.4267
Uchida A, Misksche M — Augmentation of NK cell activity in cancer patients by OK-432: activation of NK cells ano reduction of suppressor cells. In: Herber man RB, ed, NK cells and other natural effector cells. New York: Academic Press. 1982; 1303-1308. DOI: https://doi.org/10.1016/B978-0-12-341360-4.50193-1
Abruzzo LY, Rowley DA — Homeostasis of the antibody response: immunoregulation by NK celfs. Science. 1983; 222: 581-585. DOI: https://doi.org/10.1126/science.6685343
Kimata H, Shanada.n F, Brogan M, Targan S, Saxon A - Modulation of on going human immunoglobulin synthesisby natural killer cells. Cell. Immunol. 1987; 107: 74 88. DOI: https://doi.org/10.1016/0008-8749(87)90267-X
Degliantoni G, Murphy M, Kobayashi M, Francis M, Perussia B, Trinchieri G —Natural killer (NK) cell-derived hematopoietic colony-inhibiting activity and NK cytotoxic factor. Relationship with tumor necrosis factor and synergism with immune interferon. J Exp Med. 1985; 162: 1512-1530. DOI: https://doi.org/10.1084/jem.162.5.1512
Hansson M, Kiessiing R, Beivn M — Natural killing of hematopoietic cells. In: Herberman RB, ed. NK cells and other natural effector cells. New York: Academic Press. 1982; 33: 1077-1084. DOI: https://doi.org/10.1016/B978-0-12-341360-4.50159-1
Roder JC, Haliotis T, Klein M, Korec S, Jett J, Ortaldo J, Herberman RB, Katz P, Fauci AS - A new immunodeficiency disorder in humans involving NK cells. Nature 1980; 284: 553-555. DOI: https://doi.org/10.1038/284553a0
Kirk patrick CE, Farrel JP — Mechanism of depression of spienic natural killer cell function in C57BL-6 mice infected with Leishmania donovani. Cell Immunol. 1984; 87: 601-612. DOI: https://doi.org/10.1016/0008-8749(84)90028-5
IjDtzová E - C. parvum-mediated suppression of the phenomenon of natural killing and itsanalysis. In: Herberman RB, ed. Natural cell-mediated immunity against tumors. New York: Academic Press. 1980; 735-752. DOI: https://doi.org/10.1016/B978-0-12-341350-5.50060-8
Son K, Kew M, Rabson AR — Depressed natural killer activity in patients with hepatocellularcarcinoma. In vitro effects of interferon and levamisole. Cancer. 1982; 50; 2820-2825. DOI: https://doi.org/10.1002/1097-0142(19821215)50:12<2820::AID-CNCR2820501222>3.0.CO;2-#
Tursz T Dokhelar MC, Lipinski M, Amiel JL - Low natural killer cell activity in patients with malignant lymphoma. Câncer. 1982; 50; 2333-2335. DOI: https://doi.org/10.1002/1097-0142(19821201)50:11<2333::AID-CNCR2820501119>3.0.CO;2-W
Welsh RM,Zinkernagel RM - Heterospecific cytotoxic cell activity induced during the first three days of acute lymphocytic choriomeningitis virus infection in mice. Nature, 1977; 268: 646-648. DOI: https://doi.org/10.1038/268646a0
Abe T, Forbes JT, Colley DG — Natural killer cell activity during murine schistosomiasis mansoni. J Parasitol. 1983; 69: 1001-1005. DOI: https://doi.org/10.2307/3280852
Hatcher FM, Kuhn RE — Modulation of natural killer cell activity during murine infection with Trypanosoma cruzi. In: Herberman RB, ed. NK cells and other na tural effector cells. New York: Academic Press, 1982; 503-509. DOI: https://doi.org/10.1016/B978-0-12-341360-4.50081-0
Kearns RJ, Leu RW — Modulation of natural killer activity in mice following infection with Listeria monocytogenes. Cell Immunol. 1984; 361-371. DOI: https://doi.org/10.1016/0008-8749(84)90108-4
Nagel JE, Coilins GD, Adier WH — Spontaneous or natural killer cytotoxicity of K562 erythroleukemic cells in normal patients. Cancer Res. 1961; 41: 2284-2288.
Noble RL, Warren RP — Age-related deveiopment of human natural killer cell activity. New Eng J Med. 1985; 313: 641-642. DOI: https://doi.org/10.1056/NEJM198509053131017
Pross HF, Baines MG — Studies of human natural killer cells. I. In vivo parameters affecting normal cytotoxic function. Int J Câncer. 1982; 29; 383-390. DOI: https://doi.org/10.1002/ijc.2910290404
Saxena QB, Saxena RK, AdIerWH — Effect of proteincalorie mainutrition on levels of natural and inducible cytotoxic activities in mouse spleen cells. Immunology. 1984; 727-733.
Saxena QB, Saxena RK, Adler WH — Effect of feeding a diet with halfof the recommended levels of all vitamins on the natural and inducible leveis of cytotoxic activity in mouse spleen cells. Immunology. 1984, 52: 41-48.
Ferson M, EdwardsA, Lind A, Milton FW, Hersey P - Low natural killer-cell activity and immunoglobulin leveis associated with smoking in human subjects. Int J Cancer. 1979; 23: 603-609. DOI: https://doi.org/10.1002/ijc.2910230504
Phillips B, Marshall ME.Brown S, Thompson JS — Effect of smoking on human natural killer cell activity. Câncer. 1985; 56: 2789-2792. DOI: https://doi.org/10.1002/1097-0142(19851215)56:12<2789::AID-CNCR2820561213>3.0.CO;2-2
Saxena QB, Mezey E, Adler WH - Regulation of natural killer activity in vivo. II. The effect of alcohol consumption on human peripheral blood natural killer activity. Int J Cancer. 1980; 26: 413-417. DOI: https://doi.org/10.1002/ijc.2910260405
Hersey P, Edwards A, Trilivas C, Shaw H, Milton GW — Relationship of natural killer-cell activity to Rhesus antigens in man. Br J Cancer. 1979; 39; 234-240. DOI: https://doi.org/10.1038/bjc.1979.46
Santoli D, Trinchieri G, Zmijewski CM, Koprowski H – HLA-Related control of spontaneous and antibody-dependent cell-mediated cytotoxic activity in humans. J Immunol. 1976; 117: 765-770. DOI: https://doi.org/10.4049/jimmunol.117.3.765
Hellstrom I, Hellstrom KE, SjOgren HQ, Warner GA - Destruction of cultivated melanoma cells by lymphocytes from healthy black Inorth american negro) donors. Int J Cancer. 1973; 11: 116-122. DOI: https://doi.org/10.1002/ijc.2910110113
Oldham RK, Djeu JY, Cannon GB, Siwarski D, Herberman RB — Cellular mycrocytotoxicity in human tumor Systems: analysis of results, J NatI Câncer Inst. 1975; 55; 1305-1318. DOI: https://doi.org/10.1093/jnci/55.6.1305
Abo T, Cooper MD, Balch CM. — Postnatal expansion of the natural killer and killer cell population in humans identified by the monoclonal HNK-1 antibody. J Exp Med. 1982; 155: 321-326. DOI: https://doi.org/10.1084/jem.155.1.321
Forbes JT, Greco FA, Oldham RK. — Natural cell-mediated cytotoxicity in human tumor patients. In: Herberman RB, ed. Natural cell-mediated immunity against tumors. New York: Academic Press. 1982; 33: 1031-1046. DOI: https://doi.org/10.1016/B978-0-12-341350-5.50081-5
Zalis MG, de La Rocque L, Goulart J, Rumjanek VM — Modulação da atividade "natural killer". Em: Meneghini R, ed. Biologia de células em cultura. São Paulo: Publicação ACIESP. 1985; 56-75.
Antonelli P, Stewart W, Dupont B — Distributíon of natural killer cell activity in peripheral blood, cord blood, thymus, lymph nodes, and spleen and effect of in vitro treatmént with interferon preparation. Clin Immunol Immunopathol. 1981; 19: 161-169. DOI: https://doi.org/10.1016/0090-1229(81)90059-3
Thvss A, Caldani C, Bourcier C, Benita G, Schneider M — Comparison of natural killer activity during the first and second halves of the menstruai cycle in women. Letter to the editor. Br J Câncer. 1984; 50: 127-128. DOI: https://doi.org/10.1038/bjc.1984.149
Sulke AN, Jones B, Wood TJ — Varíation in natural killer activity in peripheral blood during the menstrual cycle. Br Med J. 1985; 290: 884-886. DOI: https://doi.org/10.1136/bmj.290.6472.884
White D, Jones DB, CookeT, Kirkham N — Natural killer (NK) activity in peripheral blood lymphocytes of patients with benign and malignant breast disease. Br J Câncer. 1982; 46: 611-616. DOI: https://doi.org/10.1038/bjc.1982.245
Baley JD, Schacter BZ — Mechanism of diminished natural killer cell activity in pregnant women and neonates. J Immunol. 1985; 134: 3042-3047. DOI: https://doi.org/10.4049/jimmunol.134.5.3042
Rosenberg EB, Mc Coy JL, Green SS, Donnelly FC, Siwarski DF, Levine PH, Herberman RB — Destruction of human lymphoid tissue-culturecell lines by human peripheral lymphocytes in ^'Cr-release Cellular cytotoxicity assays. J Natl Cancer Inst. 1974; 52: 345-352. DOI: https://doi.org/10.1093/jnci/52.2.345
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