A Linhagem Linfóide: Para Correlação com as Doenças Linfoproliferativas Malignas
DOI:
https://doi.org/10.32635/2176-9745.RBC.1986v32n4.3283Palavras-chave:
Fenótipo Imunológico, Anticorpos Monoclonais, Linhagem LinfóideResumo
O autor faz uma síntese dos conhecimentos atuais a respeito da linhagem linfóide normal. Mostra que a evolução nesse campo foi possível às custas da identificação de moléculas nas superfícies das células linfóides, principalmente por intermédio de anticorpos monoclonais. Apresenta esquema da linhagem linfóide com seus dois principais eixos, T e B, e destaca as diversas etapas de diferenciação desde a célula mais primitiva até a mais "madura". Tece comentários sobre as etapas de transformação blástica que tem início após o contato do linfócito com o antígeno. Às custas do conhecimento detalhado da linhagem linfóide são feitas as tipagens das doenças linfoproliferativas malignas.
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