Gengibre (Zingiber officinale) no Manejo de Náuseas e Vômitos Induzidos por Quimioterapia em Pacientes com Câncer: Revisão Integrativa da Literatura
DOI:
https://doi.org/10.32635/2176-9745.RBC.2023v69n2.3592Palavras-chave:
neoplasias/tratamento farmacológico, gengibre/efeitos adversos, plantas medicinais, fitoterapiaResumo
Introdução: Náuseas e vômitos induzidos por quimioterapia (NVIQ) são importantes efeitos colaterais dos tratamentos antineoplásicos. Algumas plantas medicinais vêm sendo estudadas no manejo desses efeitos, como o gengibre (Zingiber officinale). Objetivo: Realizar uma revisão acerca do uso via oral do gengibre no manejo de NVIQ em pacientes com câncer. Método: Revisão integrativa da literatura realizada na base de dados MEDLINE, em setembro de 2022, adotando a combinação das palavras-chave “Zingiber officinale” e “Cancer”. Foram também aplicados filtros na seleção para incluir ensaios clínicos aleatórios publicados entre 2012 e 2022. Resultados: Ao todo, foram analisados nove estudos. O gengibre apresenta potencial de reduzir NVIQ em pacientes com câncer, refletindo positivamente na qualidade de vida e na melhora do apetite e da fadiga. Os estudos não observaram efeitos adversos da administração do gengibre. Conclusão: O uso por via oral do gengibre demonstra ser uma estratégia segura para o manejo de NVIQ em pacientes com câncer, na dose de 1 g/dia do gengibre em pó, podendo ser utilizado como terapia complementar juntamente com regimes antieméticos padrões.
Downloads
Referências
Instituto Nacional de Câncer [Internet]. Rio de Janeiro: INCA; [data desconhecida]. O que é câncer? 2022 maio 31 [atualizado 2022 jul 14; acesso 2022 out 14]. Disponível em: https://www.gov.br/inca/pt-br/assuntos/cancer/o-que-e-cancer
Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3): 209-49. doi: https://doi.org/10.3322/caac.21660 DOI: https://doi.org/10.3322/caac.21660
Santos MO, Lima FCS, Martins LFL, et al. Estimativa de incidência de câncer no Brasil, 2023-2025. Rev Bras Cancerol. 2023;69(1):e-213700. doi: https://doi.org/10.32635/2176-9745.RBC.2023v69n1.3700 DOI: https://doi.org/10.32635/2176-9745.RBC.2023v69n1.3700
Silva MPN. Síndrome da anorexia-caquexia em portadores de câncer. Rev Bras Cancerol. 2006;52(1):59-77. doi: https://doi.org/10.32635/2176-9745.RBC.2006v52n1.1910 DOI: https://doi.org/10.32635/2176-9745.RBC.2006v52n1.1910
Link W. Anti-cancer drugs: discovery, development and therapy. In: De Mello R, Mountzios G, Tavares A, editors. International manual of oncology practice. Paris: Springer, Cham; 2019. p. 95-111. doi: https://doi.org/10.1007/978-3-030-16245-0_6 DOI: https://doi.org/10.1007/978-3-030-16245-0_6
Crichton M, Marshall S, Marx W, et al. Efficacy of ginger (Zingiber officinale) in ameliorating chemotherapy-induced nausea and vomiting and chemotherapy-related outcomes: a systematic review update and meta-analysis. J Acad Nutr Diet. 2019;119(12):2055-68. doi: https://doi.org/10.1016/j.jand.2019.06.009 DOI: https://doi.org/10.1016/j.jand.2019.06.009
Saad GA, Léda PHO, Sá IM, et al. Fitoterapia contemporânea: tradição e ciência na prática clínica. 3 ed. Rio de Janeiro: Guanabara Koogan; 2021.
Ministério da Saúde (BR), Gabinete do Ministro. Portaria nº 971, de 03 de maio de 2006. Aprova a Política Nacional de Práticas Integrativas e Complementares (PNPIC) no Sistema único de Saúde. Diário Oficial da União, Brasília, DF. 2006 maio 4 [acesso 2022 out 14]; Seção 1:20. Disponível em: https://bvsms.saude.gov.br/bvs/saudelegis/gm/2006/prt0971_03_05_2006.html
Chang WP, Peng YX. Does the oral administration of ginger reduce chemotherapy-induced nausea and vomiting?: a meta-analysis of 10 randomized controlled trials. Cancer Nurs. 2019;42(6):E14-E23. doi: https://doi.org/10.1097/NCC.0000000000000648 DOI: https://doi.org/10.1097/NCC.0000000000000648
Souza MT, Silva MD, Carvalho R. Integrative review: What is it? How to do it? Einstein (São Paulo). 2010;8(1):102-6. doi: https://doi.org/10.1590/S1679-45082010RW1134 DOI: https://doi.org/10.1590/s1679-45082010rw1134
Uthaipaisanwong A, Oranratanaphan S, Musigavong N. Effects of ginger adjunct to the standard prophylaxis on reducing carboplatin and paclitaxel-induced nausea vomiting: a randomized controlled study. Support Care Cancer. 2020;28(8):3831-8. doi: https://doi.org/10.1007/s00520-019-05201-5 DOI: https://doi.org/10.1007/s00520-019-05201-5
Li X, Qin Y, Liu W, et al. Efficacy of ginger in ameliorating acute and delayed chemotherapy-induced nausea and vomiting among patients with lung cancer receiving cisplatin-based regimens: a randomized controlled trial. Integr Cancer Ther. 2018;17(3):747-54. doi: https://doi.org/10.1177/1534735417753541 DOI: https://doi.org/10.1177/1534735417753541
Bossi P, Cortinovis D, Fatigoni S, et al. A randomized, double-blind, placebo-controlled, multicenter study of a ginger extract in the management of chemotherapy-induced nausea and vomiting (CINV) in patients receiving high-dose cisplatin. Ann Oncol. 2017;28(10):2547-51. doi: https://doi.org/10.1093/annonc/mdx315 DOI: https://doi.org/10.1093/annonc/mdx315
Konmun J, Danwilai K, Ngamphaiboon N, et al. A phase II randomized double-blind placebo-controlled study of 6-gingerol as an anti-emetic in solid tumor patients receiving moderately to highly emetogenic chemotherapy. Med Oncol. 2017;34(4):69. doi: https://doi.org/10.1007/s12032-017-0931-4 DOI: https://doi.org/10.1007/s12032-017-0931-4
Marx W, McCarthy AL, Ried K, et al. The effect of a standardized ginger extract on chemotherapy-induced nausea-related quality of life in patients undergoing moderately or highly emetogenic chemotherapy: a double blind, randomized, placebo controlled trial. Nutrients. 2017;9(8):867. doi: https://doi.org/10.3390/nu9080867 DOI: https://doi.org/10.3390/nu9080867
Thamlikitkul L, Srimuninnimit V, Akewanlop C, et al. Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin - cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study. Support Care Cancer. 2017;25(2):459-64. doi: https://doi.org/10.1007/s00520-016-3423-8 DOI: https://doi.org/10.1007/s00520-016-3423-8
Ansari M, Porouhan P, Mohammadianpanah M, et al. Efficacy of ginger in control of chemotherapy induced nausea and vomiting in breast cancer patients receiving doxorubicin-based chemotherapy. Asian Pac J Cancer Prev [Internet]. 2016 [cited 2022 Dec 12];17(8):3877-80. Available from: http://www.koreascience.or.kr/article/JAKO201617847602754.page
Sanaati F, Najafi S, Kashaninia Z, et al. Effect of ginger and chamomile on nausea and vomiting caused by chemotherapy in Iranian women with breast cancer. Asian Pac J Cancer Prev [Internet]. 2016 [cited 2022 Dec 12];17(8):4125-9. Available from: http://www.koreascience.or.kr/article/JAKO201617847602969.page
Arslan M, Ozdemir L. Oral intake of ginger for chemotherapy-induced nausea and vomiting among women with breast cancer. Clin J Oncol Nurs. 2015;19(5):E92-7. doi: https://doi.org/10.1188/15.CJON.E92-E97 DOI: https://doi.org/10.1188/15.CJON.E92-E97
Ryan JL, Heckler CE, Roscoe JA, et al. Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients. Support Care Cancer. 2012;20(7):1479-89. doi: https://doi.org/10.1007/s00520-011-1236-3 DOI: https://doi.org/10.1007/s00520-011-1236-3
Silva RLM, Silva TTM, Pessoa RL, et al. Use of ginger to control nausea and vomiting caused by chemotherapy in patients with cervical cancer undergoing treatment: an experiment. Medicine (Baltimore). 2022;101(24):e29403. doi: https://doi.org/10.1097/MD.0000000000029403 DOI: https://doi.org/10.1097/MD.0000000000029403
Wazqar DY, Thabet HA, Safwat AM. A quasi-experimental study of the effect of ginger tea on preventing nausea and vomiting in patients with gynecological cancers receiving cisplatin-based regimens. Cancer Nurs. 2021;44(6):E513-9. doi: https://doi.org/10.1097/NCC.0000000000000939 DOI: https://doi.org/10.1097/NCC.0000000000000939
Tian L, Qian W, Qian Q, et al. Gingerol inhibits cisplatin-induced acute and delayed emesis in rats and minks by regulating the central and peripheral 5-HT, SP, and DA systems. J Nat Med. 2020;74(2):353-70. doi: https://doi.org/10.1007/s11418-019-01372-x DOI: https://doi.org/10.1007/s11418-019-01372-x
Fahimi F, Khodadad K, Amini S, et al. Evaluating the effect of Zingiber officinalis on nausea and vomiting in patients receiving cisplatin based regimens. Iran J Pharm Res. 2011;10(2):379-84. doi: https://doi.org/10.22037/ijpr.2011.969
Haniadka R, Saldanha E, Sunita V, et al. A review of the gastroprotective effects of ginger (Zingiber officinale Roscoe). Food Funct. 2013;4(6):845-55. doi: https://doi.org/10.1039/C3FO30337C DOI: https://doi.org/10.1039/c3fo30337c
Marx WM, Teleni L, McCarthy AL, et al. Ginger (Zingiber officinale) and chemotherapy-induced nausea and vomiting: a systematic literature review. Nutr Rev. 2013;71(4):245-54. doi: https://doi.org/10.1111/nure.12016 DOI: https://doi.org/10.1111/nure.12016
Zick SM, Ruffin MT, Lee J, et al. Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting. Support Care Cancer. 2009;17(5):563-72. doi: https://doi.org/10.1007/s00520-008-0528-8 DOI: https://doi.org/10.1007/s00520-008-0528-8
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Os direitos morais e intelectuais dos artigos pertencem aos respectivos autores, que concedem à RBC o direito de publicação.
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
