Integração de Dados Atuais dos Linfossarcomas na Classificação da OMS, Seu Valor Para Previsão do Prognóstico e Adaptação da Terapêutica do Prognóstico
DOI:
https://doi.org/10.32635/2176-9745.RBC.1978v28n4.3598Palavras-chave:
Linfoma/classificação, Linfoma não Hodgkin, PrognósticoResumo
A identificação dos linfossarcomas com os marcadores imunológicos enriqueceu o valor prognóstico da Classificação OMS. O prolinfocítico (centrofolicular) tipo B e o subtipo linfoblástico nulo* têm um bom prognóstico enquanto que o tipo Imunoblástico (T ou B) e o subtipo linfoblástico T têm um prognóstico pobre. Muitas classificações de Hematossarcomas ou Linfossarcomas malignos Não Hodgkin foram propostas (3, 9, 16, 17, 22, 23, 29). Algumas ainda são usadas, principalmente aquela de Rappaport (29), que foi concebida antes do estabelecimento do conceito da transformação de linfócitos pelo antígeno(s) em células grandes pironinofílicas, as quais eram confundidas com "histiócitos" antes desse conceito e foram chamadas Imunoblastos por Dameschek (7). A recente utilização de marcadores imunológicos e/ou citoquímicos capazes de reconhecer os linfócitos T e B e os assim chamados nulos (Tabela I) (6, 13, 31, 36, 38) não somente retiraram dos assim chamados tumores "histiocíticos" o Linfossarcoma Imunoblástico (20), mas também a Micose Fungóide identificada como um Linfossarcoma T. (18).
Trabalho publicado na Revista Biomedicine; Paris, França,26 (6) :377 - 384, 1977.
Traduzido por: J. C. Machado e M. L. S. Rodrigues (Comissão Nacional de Linfomas Malignos da Dinecrode e Instituto Butantan),
Downloads
Referências
BELPOMME D., LELARGE N., MATHÉ, G.& DAVIES, A.J.S.: Etiological, clinical and prognostic significance of theT-B immunological classification of primary acute lymphoid leukaemias and Non-Hodgkin's lymphomas. P. 33 in Immunological diagnosis of leukaemias and lymphomas. S. Theirfelder, H. Rodt &E. Thiel, eds. Springer-verlag Heidelberg — New York, 1977. DOI: https://doi.org/10.1007/978-3-642-66639-1_4
BELPOMME D., MATHÉ, G. & DAVIES, A. J. S. Clinical significance and prognostic value of the T-B immunological classification of human primary acute lymphoid leukaemias. Lancet, 1977, I, 555. DOI: https://doi.org/10.1016/S0140-6736(77)91994-8
BENNETT, M. H., FARRER-BROWN G., HENRY, K. & JELIFFE, A. M.: Classification of non-Hodgkin's lymphomas. Lancet, 1974, I, 1295. DOI: https://doi.org/10.1016/S0140-6736(74)90061-0
BILLING R., RAFIZADEH B., DRES I., HARTMAN G., GALE R. SiTERASAKI P.: Human B-lymphocyte antigen expressed by lymphocytic and myelocytic leukaemic cells. J. exp. Med., 1976, 144, 167. DOI: https://doi.org/10.1084/jem.144.1.167
BINET, J. L. & MATHÉ G.: Optical and electron microscopy studies of the immunological competent cells during the reaction of the graft versus host. N. Y. Acad. Sei., 1962, 99, 426. DOI: https://doi.org/10.1111/j.1749-6632.1962.tb45325.x
CATOWSKY D., GALETTO, J., OKOS A., MILANI E. 8(GALTON, D. A. G.: Cytochemical prolife of B and T leukaemic lymphocytes with special reference to acute lymphoblastic leukaemia. J. Clin. Pathol. 1974, 27, 767. DOI: https://doi.org/10.1136/jcp.27.10.767
DAMESHEK, W. ‘'Immunoblasts" and "Immunocytes": an attempt at a functional nomenclature. Blood, 1963, 21, 243. DOI: https://doi.org/10.1182/blood.V21.2.243.243
DANTCHEV D. &BELPOMME D.:Critical study of the mononuclear leukocyte morphology based on seanning electron microscopy in normal subjects and in patients with lymphoid or monocytoid proliferative disorders. Comparison with theT, B or null cell membrane phenotypes. Biomedicine, 1976, 26, 202.
DORFMAN, R. F. :The non-Hodgkin's lymphomas. P. 262 in Reticulo endothelial System. J. W. Rebuck, C. W. Berard & M. R. Abell, eds. Williams and Wilkins, Baltimore, 1975.
GREAVES, M.F., BROWN G., RAPSON, N. 8LISTER, T. A.: Antisera to acute lymphoblastic leukaemia cells. Clin. Immunol. Immunoth., 1975, 4, 67. DOI: https://doi.org/10.1016/0090-1229(75)90041-0
HAUSEN H. zur Oncogenic herpes virus. Biochim. Biophys. Acta, 1975, 417, 25. DOI: https://doi.org/10.1016/0304-419X(75)90007-4
JANOSSY, G., ROBERTS, M. & GREAVES, M. F. Target cell in chronic myeloid leukaemia and its relationship to acute lymphoid leukaemia. Lancet, 1976, I, 1058. DOI: https://doi.org/10.1016/S0140-6736(76)90970-3
JONDAL, M., HOLM, G. SiWIGZELL, H.. A large population of lymphocytes forming non- immune rosettes with sheep red blood cells. J. Exp. Med., 1972, 136, 207. DOI: https://doi.org/10.1084/jem.136.2.207
KADIN M. E., GARRATY E. &SCALAPINO, J.: Detection of a new B-membrane antigen in Hodgkin's disease and non-Hodgkin's lymphomas. Proc. Amer. Assoe. Cancer Res., 1977, 18, 29 (abst. 113).
KERSEY, J., SABAD, A., GAJL-PECZALSKA, K., HALLGREN H., YUNIS, E. &NESBIT M.: Acute lymphoblastic leukaemia cells with markers of T (thymus derived) lymphocytes. Science, 1973, 182, 1355. DOI: https://doi.org/10.1126/science.182.4119.1355
LENNERT, K., MOHRI, N. STEIN H, &KAISERLING, E.:The histopathology of malignant lymphoma. Brit. J. Haematol., 1975, 31 (suppl.), 193. DOI: https://doi.org/10.1111/j.1365-2141.1975.tb00911.x
LUKES, R.J &COLLINS, R.D.: A functional classification of malignant lymphomas. P. 213 in The reticulo-endothelial system. J.W. Rebuck, C.W. Berard & M.R. Abell, eds. Williams and Wilkins, Baltimore, 1975.
LUTZNER M., EDELSON R., SCHEIN, P., GREEN L, KIRKPATRICK C. &AHMED A.: Cutaneous T. Cell lymphomas: The Sezary syndrome mycosis fungoides and related disorders. Ann. Inter. Med., 1975, 83, 534. DOI: https://doi.org/10.7326/0003-4819-83-4-534
MANN, R. B., JAFFE, E. S., BRAYLAN R.C.; NANBA, K., FRANK, M.M., ZIEGLER, J.L. & BERARD C. W.: Non-endemic Burkitfs lymphoma. A B-cell tumor related to germinal centers. New EngI, J. Med. 1976, 295, 685. DOI: https://doi.org/10.1056/NEJM197609232951301
MATHÉ, G., BELPOMME, D., DANTCHEV D., KHALIL, A. M., AFIFl A. M., TALEB N., POUILLART P., SCHWARZENBERG L., HAYAT M., DE VASSAL F., JASMIN C., MISSET J. L. & MUSSET M.: Immunoblastic Lymphosarcoma. A cytological and clinical entity. Biomedicine, 1975, 22, 473.
MATHÉ, G. POUILART, P., STERESCU M., AMIELJ. L., SCHWARZENBERG L., SCHNEIDER M., HAYAT M., DE VASSAL F., JASMIN C. & LAFLEUR M.:Sub division of clinicai varieties of acute leukemia. Correlation With prognosís and cure expectancy Europ. J. Clin. Biol. Res., 1971, 16, 554.
MATHÉ G., RAPPAPORT, H., O'CONOR G. T. & TORLONI, H.; Histological and cytological typing of neoplastic diseases of haematopoietic and lymphoid tissues. World Health Organization, Geneva, 1976.
MATHÉ G. &SEMAN G.: Aspects histologiques et cytologiques des leucémies et hématosarcomes. Maloine, Paris, 1963.
MISSET J. L., MATHÉ G., TUBIANA M., CAILLOU B., POUILLART, P. GIL M., TENTAS C. & DELGADO, M.: Preliminary results of chemoradiotherapy followed or not by active immunotherapy of stage III and IV lymphosarcoma and reticulosarcoma. Correlation of the resuits with WHO categorisation. In Lymphoid neoplasias. G. Mathé, M. Seligmann &M. Tubiana, eds. Springer-verlag. Heidelberg-New-York, 1977, in press. DOI: https://doi.org/10.1007/978-3-642-81249-1_23
NATHWANI, B. N., KIM, H. &RAPPAPORT, H. Malignant Lymphoma lymphoblastic. Cancer, 1976, 38, 964. DOI: https://doi.org/10.1002/1097-0142(197608)38:2<964::AID-CNCR2820380248>3.0.CO;2-V
O'CONOR G. T. Histopathological classification of Burkitt's tumour. Bull. World Health Org., 1969,40,601.
OBERLING G: Les réticulosarcomes et les réticulo-endothéliosarcomes de Ia moelle osseuse (sarcome d'Ewing). Bull. Ass. Franç. Cancer, 1928, 17, 259.
PAZMINO.N. H., MAC EWAN, R. N.&IHLE J. N.; Terminal transferases: enzyme marker for a specific prothymocyte cell populations. Proc. Amer. Assoe. Câncer. Res., 1977, 18, 81 (abst. 322)
RAPPAPORT H.: Tumors of the hematopoietic Systems. In Atlas of tumor pathology. Section 3, Fase. 8. Armed Forces Institute Pathology, Washington, 1966.
SCFI L0SSMANN, S.S. personal commuhication.
SELIGMANN M., PREUD'HOMME J. L. & BROUET J.C.B. and T cell markers in human proliferative blood diseases and primary immunodeficiences with special references to membrane bound immunoglobulins. Transplant. Rev., 1973, 16, 85. DOI: https://doi.org/10.1111/j.1600-065X.1973.tb00118.x
SEN L. &BORELLA L.: Clinical importance of lymphoblasts with T markers in childhood acute leukaemia. New Engl. J. Med. 1975, 292, 828. DOI: https://doi.org/10.1056/NEJM197504172921604
STEINMAN R. M. &COHN Z.A. Identification of a novel cell type in peripheral lymphoid organs of mice. I . Morphology, quantitation, tissue distribution. J. exp. Med., 1973, 123. DOI: https://doi.org/10.1084/jem.137.5.1142
STEINMAN R. M., LUSTIG D.S. &COHN Z. A.: Identification of a novel cell type in peripheral lymphoid organs of mice. II. Functional properties in vivo. J. exp. Med., 1974, 139, 1431. DOI: https://doi.org/10.1084/jem.139.6.1431
STEINMAN R.M., Adams J.C. & COHN Z.A. Identification of a novel cell type in peripheral lymphoid organs of mice. I II. Identification and distribution in mouse spleen. J. exp. Med., 1975, 141, 804. DOI: https://doi.org/10.1084/jem.141.4.804
TAYLOR C.R. &BURNS J.: The demonstration of plasma cells and other immunoglobulin - containing cells in formalinfixed, paraffin embedded tissues using peroxidase-labelled antibody J. clin. Path., 1974, 27, 14. DOI: https://doi.org/10.1136/jcp.27.1.14
VAN FURTH R., COHN, Z.A., HIRSCH J.G. HUMPHREY, J.H. SPECTOR W.G. &LANGEVOORT, H. L.: The mononuclear phagocyte System: a new classification of macrophages, monocytes and their precursor cells. Bull. World Health Org., 1972, 46, 845.
WYBRAN, J., CAN M.C. &FUDENBERG H. H.: The human rosette forming cells as a marker of a population of thymus derived cells J. clin. Invest. 1972, 51, 2537. DOI: https://doi.org/10.1172/JCI107069
YAM, L. T., TAVASSOLI M. & JACOBS P.: Differential characterization of the "reticulum cell" in lymphoreticular neoplasma Amer. J. clin. Pathol. 1975,64, 171. DOI: https://doi.org/10.1093/ajcp/64.2.171
ZIEGLERJ. L. Treatment result of 54 American patients with Burkitt's lymphoma are similar to the African experience. New Engl. J. Med. 1977, 297, 75. DOI: https://doi.org/10.1056/NEJM197707142970202
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
