Diferenciação Celular: Um Problema em Oncologia
DOI:
https://doi.org/10.32635/2176-9745.RBC.1978v28n4.3607Palavras-chave:
Diferenciação Celular, Oncologia, Metaplasia, Gradação de TumoresResumo
Este trabalho é uma revisão do processo da diferenciação celular, enfocado, de modo especial, em nível molecular. O câncer pode ser considerado como uma doença da regulação gênica, fruto de uma aberrante modificação da expressão gênica. Algumas situações práticas, afora o câncer, são também consideradas no escrito, como, por exemplo, a metaplasia e a gradação histológica dos tumores malignos.
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BASERGA, R. and WIEBEL, F. - The cell cycle of mammalian cells. Acta Path. Et Microb. Scand. 214: 1 - 30, 1970.
BOLUND, L. RINGERTZ, NR and HARRIS, H. - Changes in the cytochemical properties of erytrocyte nuclel reactivated by cell fusion. J. Cell Sci. 4: 71-87, 1969. DOI: https://doi.org/10.1242/jcs.4.1.71
BRITTEN, RJ., and DAVIDSON, EH. – Gene regulation for higher cells: a theory. Science. 165: 349-357, 1969. DOI: https://doi.org/10.1126/science.165.3891.349
BRITTEN, RJ and DAVIDSON, EH. - Repetitiva and non-repetitive DNA sequences and a speculation on origens of evolucionary novelty. Quart. Rev. Biol. 46: 111-138, 1971. DOI: https://doi.org/10.1086/406830
BULLOUGH, WS. Growth regulation by tissue-specific factors or chalones. In Emmelot P and Muhibock, O (ED) — Cellular control mechanisms and cancer. EIsevier Publ. Co. Amsterdam. 1964.
DAVIDSON, EH and BRITTEN, RJ. - Proceedings molecular aspects of gene regulation in animal cells. Cancer Ret. 34: 2034-2043, 1974.
DE ROBERTIS, EDP, NOWINSKI WM. Y SAEZ, FA. — Biologia celular. El Atheneo. B. Aires. 1970.
DRIESCH, H. — Entwicklungsmechanische Studien. I. Der Werth der beiden ersten Furchungszellen in der Echinodermentwicklun. Experimentalle Erzeugung von Theil-und Doppel bildungen. 2 — Uber die Beziehungen des Lichtes zur ersten Etappe der thierischens Formbildung. Zeits f. wiss Zool. 53: 160-184, 1891. (In Hamilton e col.).
DUSTIN, Jr. P. - Cell differentiation and carcinogenesis. A criticai review. Cell tissue kineties. 5: 519-533, 1972. DOI: https://doi.org/10.1111/j.1365-2184.1972.tb00389.x
EMMELOT, P. - Introduction. In Cellular control mechanisms and cancer, pp. 1-7. Emmelot, P. and Muhibock, O. (ED). Elsevier. Publ. Co. Amsterdam. 1964.
FABRIKANT, Jl. - Studies on cell population Kineties in regerating liver. In Human tumor cell kineties. Monograph 30. Natl. Cancer Inst. Washington. 1968.
FELDMAN, M. YAFFE, D. and GLOBERSON, A. - Some cellular and molecular aspects of cytodifferentiation. In Cellular control mechanisms and cancer, pp. 60-79. Emmelot, P. and Muhibock, O (ED). Elsevier Publ. Co. Amsterdam. 1964.
FOULDS, L. — Tumor progression and neoplastic development. In Cellular control mechanisms and cancer. Emmelot. P. and Muhlbock. O. (ED). EIsivier Publ. Co. Amsterdam. 1964.
GROBSTEIN, C. — Differentiation of vertebrate cells. In The cell. J. Brachet and Mirsky, AE. (ED). Vol. 1 - p. 47. Academic Press. London. 1959. DOI: https://doi.org/10.1016/B978-0-12-123301-3.50017-3
GROBSTEIN, C. — Interaction among cells in relation to cytodifferentiation. In Differentiation and development. Littie Brown. Co. Boston, pp. 121-125, 1964. DOI: https://doi.org/10.1002/jez.1401570117
GURDON, JB and BROWN, DD. - Cytoplasmatic regulation of RNA synthesis and nucleous formation in developing embryos of Xenopus laevis. J. Mol. Biol. 12: 27-35, 1965. DOI: https://doi.org/10.1016/S0022-2836(65)80279-0
HAMILTON, WJ., BOYD, JD, and MOSSMAN, HW. — Human Embriology. The Williams and Wilkins Co. Baltimore. 2 sd. Ed. 1952.
HARRIS, H. SIDEBOTTOM, E., GRACE, DM and BRAMWELL, ME. - The expresion of genetic information: a study with hybrid animal cells. J. Cell. Sci. 4: 499-525, 1969. DOI: https://doi.org/10.1242/jcs.4.2.499
HOWARD, A. and PELC, SR. – SYNTHESIS of desoxyribonucleic acid in normal and irradiated cells and its relation to chromosome breakage. Heredity (suppl.) 6: 261-273, 1953.
INGRAN, VM. — The hemoglobin in genetics and evolution. Columbia Univ. Press. N.Y. 1963.
JACOB, F. and MONOD, J. Symp. Dev. Growth. 21 ;30, 1963 (In Dustin, Jr. P). DOI: https://doi.org/10.1016/B978-0-12-395555-5.50008-6
KAUFMAN, S. — Differentiation of malignant to begin cells. J. Theor. Biol. 31: 429-451, 1951. DOI: https://doi.org/10.1016/0022-5193(71)90020-8
LAJTHA, LG. - Differential sensivity of the cell life cycle. J. Cell. Comp. Physiol. 62 (suppl) 141-156, 1965. DOI: https://doi.org/10.1002/jcp.1030620413
MANIATIS, T. and PTASHINE, M. – DNA operator-repressor system. Scient. Amer. 38: 64-76, 1974. DOI: https://doi.org/10.1038/scientificamerican0176-64
MARKERT, CL. — Biochemical events during differentiation. In Differentiation and development. Little. Brown and Co. Boston. 1964. DOI: https://doi.org/10.1002/jez.1401570113
PIERCE, GB. and WALLACE, C. - Differentiation of malignant to benign cells. Cancer Res. 31: 127-134, 1971.
PITOT, H. and HEILDELBERGER, C. - Metabolic regulatory circuits and carcinogenesis. Cancer Res. 23: 1964-1983, 1963.
POTTER, VR. - Recent trends in cancer biochemistry: the importance of fetal tissue. Canadian Cancer Conf. 8: 9-31, 1969.
STONEHILL, EH. and BENDICH, A. - Retrogentic expression: the reapperance of embryonal antigen in cancer cells. Nature (London) 228: 370-372, 1970. DOI: https://doi.org/10.1038/228370a0
TSANEV, R. and SENDOV, BL. – Possible molecular mechanisms for cell differentiation in multicellular organisms. J. Theor. Biol. 30: 337-393, 1971. DOI: https://doi.org/10.1016/0022-5193(71)90059-2
WALKER, PM. - Repetitive DNA in higher organisms. Prog. Biophy. Mol. Biol. 23: 145-190, 1971. DOI: https://doi.org/10.1016/0079-6107(71)90019-8
WEISS, P. — Perspectives in the field of morphogenesis. Quaet. Rev. Biol. 25: 177-198, 1950. DOI: https://doi.org/10.1086/397540
WEISS, P. - Differential growth. Dynamics of development. Academic Press. New York. 1968. DOI: https://doi.org/10.1016/B978-1-4832-2919-5.50013-1
WEISTEIN, IB. Mollecular and cellular mechanisms of Chemical carcinogenesis. Adv. Pathobiol. 2: 4-9, 1976.
WESSELLS, NK. — Tissue interactions and óytodifferentiation. IN Differentiation and Development. Little. Brown. Co. Boston. 1964.
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