Um Estudo Experimental Sôbre a Dinâmica da Regeneração Hepática
DOI:
https://doi.org/10.32635/2176-9745.RBC.1964v20n27.3743Palavras-chave:
Regeneração Hepática, Regeneração Hepática/fisiologia, IntoxicaçãoResumo
O Autor desenvolve considerações iniciais sôbre a arquitetura hepática segundo os pontos de vista sustentados por Rappaport, acentuando também a existência de diferenças funcionais entre as duas zonas do acino hepático. Para demonstrar a validade dessas proposições estudou-se a intoxicação tioacetamídica nos seus aspectos morfológicos e dinâmicos. O autor também estuda e discute a influência do equilíbrio endócrino sôbre a regeneração bepática, concluindo por propor uma hipótese de trabalho, segundo a qual o estímulo desencadeador da regeneração hepática seria um excesso relativo de hormônios e metabolitos circulantes, que se seguiria a uma hepatectomia parcial ou a destruição do parênquima hepático.
Downloads
Referências
ELIAS, H. — Re-examination of the structure of the mammalian liver. I. Parenchymal Architecture. Am. J. Anat. 84; 311,1949. DOI: https://doi.org/10.1002/aja.1000840206
ELIAS, H. — The structure of the live of vertebrates. Acta Anat. 14: 297, 1952. DOI: https://doi.org/10.1159/000140715
RAPPAPORT, A. M. — “The structural and functional acinar unit of the liver; some histopathological considerations”. Hepatitis Frontiers, Little Brown, Co., 1957.
RAPPAPORT, A. M. — The Structural and functional unit in the human liver (liver acinus). The Anatomical Record, 130; 673, 1958. DOI: https://doi.org/10.1002/ar.1091300405
RAPPAPORT, A. M. e HIRAKI, G. Y. — Histopathologic changes in the structural and functional unit of the human liver. Acta Anatômica, 32; 240, 1958. DOI: https://doi.org/10.1159/000141326
RAPPAPORT, A. M. e HIRAKI, G. Y.— The anatomical pattern of lesions in the liver. Acta Anatômica, 32: 126, 1958. DOI: https://doi.org/10.1159/000141318
WACHENSTEIN, M. — Enzymatic histochemistry of the liver. Gastroenterology, 37: 525, 1959. DOI: https://doi.org/10.1016/S0016-5085(19)35357-0
NOVIKOFF, A. B. — The biochemical cytology of liver. Bulletin of the New York Academy of Medecine, 35: 67, 1958.
NOVIKOFF, A. B. e ESSNER, E. — The liver cell. The American Journal of Medicine, 29: 102, 1960. DOI: https://doi.org/10.1016/0002-9343(60)90011-5
WEINBREN, K. the liver. Regeneration of the liver Gastroenterology, 37; 657, 1959. DOI: https://doi.org/10.1016/S0016-5085(19)35367-3
BUCHER, N. R. L.; SCOTT, J. F. e AUB, J. C. — Regeneration of liver in parabiotic rats. Cancer Res., 11: 457, 1951.
FBIEDRICH-FREKSA, H. e ZAKI, F. G. — Spezifische Mitose-Auslosung in normaler ratten-Leber duch von partieel hepatectomierten ratten Zeit-schrift fur Naturforschung, 9b; 394, 1954. DOI: https://doi.org/10.1515/znb-1954-0603
ADIBI, S. K.; PASCHKIS, E. e CANTAROW, A. — Stimulation of liver mitosis by blood serum from hepatectomized rats. Exptl. Cell Res., 18; 396, 1959. DOI: https://doi.org/10.1016/0014-4827(59)90024-2
GLINOS, A. D. e GEY, G. O. — Hormonal factors involved in the induction of liver regeneration in the rat. Proc. Soc. Exp. Biol. Med., 80: 421, 1952. DOI: https://doi.org/10.3181/00379727-80-19643
GLINOS, A. D. Evidence for a negative feed-back system controling liver regeneration. Symposium on Information Theory in Biology, Pergamon Press, 1956.
GLINOS, A. D. — Environmental feedback control of cell division. Annals of the New York Academy of Sciences, 90: 592, 1960. DOI: https://doi.org/10.1111/j.1749-6632.1960.tb23275.x
KELLY, L.; HIRSCH, J. D.; BEACH, G. e PALMER, W. — The time function of P 32 incorporation into DNA of regenerating liver: the effect of irradiation. Câncer Res., 17: 117, 1957. DOI: https://doi.org/10.2172/4343660
CASPERSSON, T.; KLEIN, E. e Ringertz, N. R. — Cytochemical studies on some effects of X-radiation on three ascites tumors. Câncer Res., 18: 857, 1958.
WILLIAMS, R. B.; TO AL, J. N.; WHITE, J. e CARPENTER, H. M. — The effect of total-body x-radiations from near threashold to tissue lethal doses on the small bowell epithelium of the rat. Research Repport. NM 6202000201. Naval Medical Research Institute, Bethesda, Marynland.
TOAL, J. N.; REICH, J. C.; WILLIAMS, R. B. e WHITE, J. — Effect of totalbody x-irradiation from near threa shold to tissue lethal doses on the small bowell epithelium of the rat. Research Repport. NM 6202000202. Naval Medical Research Inst., Bethesda, Marynland.
DUCOFF, H. S. e EHRET, C. F. — Mitogenesis. The University of Chicago Press, 1956.
PRESCOT, D. M. — Relation between cell growth and cell division. IV. The synthesis of DNA, RNA and protein from division to division in Tetrahymema. Exptl. Cell Res., 19: 228, 1960 DOI: https://doi.org/10.1016/0014-4827(60)90004-5
GELFANT, S. — Initiation of mitosis in relation to the cell division cycle. Exptl. Cell Res., 26: 395, 1962. DOI: https://doi.org/10.1016/0014-4827(62)90191-X
PUCK, T. T. e MARCUS, P. I. — Action of x-rays on mammalian cells. J. Exper. Med., 103: 653, 1956. DOI: https://doi.org/10.1084/jem.103.5.653
TOLMACH, L. J. e MARCUS, P. I. — Development of x-ray induced giant Hela cells. Exptl. Cell Res., 20: 350, 1960. DOI: https://doi.org/10.1016/0014-4827(60)90163-4
SHEEK, M. R.; DESARMIER, R. M; SAGIK, B. P. e MAGEE, W. E. — Biochemical changes during the formation and growth of giant cells from irradiated Hela cells. Exptl. Cell Res., 19: 549, 1960. DOI: https://doi.org/10.1016/0014-4827(60)90063-X
MAC DONALD, R. A. e ROGERS, A. E. — Lack of effect of plasma from partially hepatectomized cirrhotic and normal rats on deoxyribonucleic acid synthesis and mitosis in rat liver. Gastroenterology, 41: 33, 1961.
ROGERS, A. E.; SHAKA, J. A.; PECHET G. e MAC DONALD, R. A. — Absence of a “humoral factor” affecting hepatic regeneration in parabiotic rats. Am. J. Path., 39: 561, 1961.
ALSTON, W. C. e THOMSON, R. Y. — Humoral and local factors in liver regeneration. Câncer Res., 23: 901. 1963.
FISHER, B.; FISHER, E. R. e SAFFER, E. Investigation concerning the role of a humoral factor in liver regeneration. Câncer Res., 23: 914, 1963
VAN POTTER, R. e AUERBACH, V. H Adaptive enzyme and feed-back mechanism. Lab. Investigat, 8: 495, 1959.
SCHAPIRA, F. — L’adaptation enzymatique chez les animaux superieurs. Revue Françoise cl’etudes cliniques ct biologiques, 5: 722, 1960.
QUASTLER, H. — Chemical communication Systems in the cell. Transactions of the New York Academy of Sciences, 25: 382, 1963. DOI: https://doi.org/10.1111/j.2164-0947.1963.tb01462.x
PITOT, H. C. e HEIDELBERGER, C. — Metabolic regulatory circuits and carcinogenesis. Cancer Res., 23: 1694, 1933
SWARTZ, F., SAMS, B. F. e BARTON. A. G. — Polyploidization of rat liver following castration of males and females. Exptl. Cell Res., 20: 438, 1930. DOI: https://doi.org/10.1016/0014-4827(60)90172-5
CHILDS, J. F. L. e SIEGLER, E. A. — Controlling orange decay. Industrial and Eng. Chem., 38: 82, 1346. DOI: https://doi.org/10.1021/ie50433a034
FITZHUGH O. G. e NIELSCN A. A. — Liver tumors in rats fed thiourea and thioacetamide. Science, 108: 626, 1948. DOI: https://doi.org/10.1126/science.108.2814.626
AMBROSE, A. M., DEEDS, F. e RATHER, L. J. — Toxicity of thioacetamide in rats. J. Industr. Higi. a Toxicol., 31: 158, 1949.
RATHER, L. J. — Experimental alteration of nuclear and cytoplasrnic componentes of the liver cell with thioacetamide. Bull. Johns Hopkins Hosp., 88: 38, 1951.
CARNES, W. H., BERNSTEIN, D. S. e RATHER, L. J. — Effect of thioacetamide on the desoxiribonucleic contente of liver cells. Federation Proc., 12: 385, 1953.
LAIRD, A. K. Nuclear changes induced in rat liver cells by thioacetamide. Arch. Biochem. and Biophysics, 46: 119, 1953. DOI: https://doi.org/10.1016/0003-9861(53)90175-1
NYGAARD, O., ELDJARN, L, e NAKKEN, K. F. — Studies on the metabolims of. thioacetamide — S35 in the intact rat. Cancer Res., 14: 625, 1954.
HEIZER, P. — Desoribose nucleic acid (DNA) content size and size of rat liver nuclei during thioacetamide intoxication and recovery. Chromossoma Band. 7: 281, 1955, DOI: https://doi.org/10.1007/BF00329729
GUPTA, D. N. — Production of cancer of the bile ducts with thioacetamide. Nature, 175: 257, 1955. DOI: https://doi.org/10.1038/175257a0
GUPTA, D. N. — Acute changes in the liver after administration of thioacetamide. J. Path. Bact. 72: 1953.
GUPTA, D. N. — Nodular cirrhosis and metastasizing tumors produced in the liver of the rats by prolonged feeding with thioacetamide. J. Path. Bact. 72: 415, 1956. DOI: https://doi.org/10.1002/path.1700720207
GALLAGHER, C. H., GUPTA, D. N., JUDAH, J. D. e REES, K. R. — Biochemical changes in liver in acute thioacetamide intoxication, J. Path. Bact., 72: 193, 1956. DOI: https://doi.org/10.1002/path.1700720125
KLEINFELD, R. G. — Early changes in rat. liver and kidney cells induced by thioacetamide. Câncer Res. 17: 954. 1957.
KLEINFELD, R. G. e HAAM, E. Von — The effect of thioacetamide on rat liver regeneration. I. Citolgical studies. Cancer Res., 19: 769, 1959.
KLEINFELD, R. G. HANN, E. Von — Effect of thioacetamide on rat liver regeneration. II. Nuclear RNA in mitosis, J. Biofhysic and Biochem Cytol, 6: 393, 1959. DOI: https://doi.org/10.1083/jcb.6.3.393
GRANT H. C. e REES, V. R. — The precancerous liver correlation of histological and histochemical changes in rats during prolonged administration of thioacetamide and butter yellow Proceedings of the Royal Society, 148: 930, 1958. DOI: https://doi.org/10.1098/rspb.1958.0010
BAKER, E. A., SMUCKLER, E. A. c BENDITT, E. P. —- Effect of thioacetamide and yellow phosphorus poisoning on protein synthesis in vivo. Lab. Investigat., 12: 995, 1963.
ADAMS, H. R. e BUSOH, H. — Effects of thioacetamide on incorporation of orotic acid-2-Ci4 into RNA fractions in liver. Câncer Research, 23: 576, 1963.
MURAMATSU, M. e BUSCH, H. — Effects of thioacetamide on metabolism of proteins of normal and regenerating liver. Câncer Res., 22: 1100, 1962.
SULKIN, N. M. A study of the nucleus in the normal and hyperplastic liver of the rat. Am. J. Anat., 73: 107, 1943. DOI: https://doi.org/10.1002/aja.1000730106
PCST, J., HIMES, M. B., KLEIN, A, e HOFFMAN, J. — Responses of liver to injury. Arch. Path., 64: 278, 1957.
HARKNESS, R. D. The spatial distribution of dividing cells in the liver of the rat after partial hepatectomy. J. Physiol., 116: 373, 1953. DOI: https://doi.org/10.1113/jphysiol.1952.sp004711
HARTROFT, W. S. — “Experimental hepatic injury” in Diseases of the liver. J. B. Lippincott Co., 1956.
MACKAY, E. M. e BARNES, R. H. — Choline and pancrea extract on fatty livers and ketosis due to anterior pituitary extract. Proc. Soc. Exper. Biol. Med., 38: 803, 1938. DOI: https://doi.org/10.3181/00379727-38-10022
SHIPLEY, R. A., CHADZIK, E. B. e GYORGY, P. Effect of extirpation of various giands ond production of fatty liver. Arch. Biochem., 16: 301. 1948.
EMERSON, W. J., ZANNARIK, P. C. e NATHANSON, I. T. — The effect of sex hormones on hepatic and renal lesions. Endodrinology, 48: 548, 1951. DOI: https://doi.org/10.1210/endo-48-5-548
HANDLER, P. e FOLLIS, R. H. — Role of thyroid activity in the pathogenesis of hepatic lesion due to choline and cystine deficiency. J. Nutrition, 35. 669, 1948. DOI: https://doi.org/10.1093/jn/35.6.669
TANNENBERG, J. Pathological changes in the heart, skeletal muscle and liver in rabbits treated with insulin in shock dosage. Am. J. Path., 15: 25, 1939.
DEANE, H. W. e GREEP, R. O. — A morphological and histochemical study of the rat adrenal cortex after hypophysectomy with comments on the liver. Am. J. Anat., 79: 117, 1946. DOI: https://doi.org/10.1002/aja.1000790104
DRABKIN, D. L, — Liver regeneration and cytochrome metabolism. J. Bioal. Chem., 171: 395, 1947. DOI: https://doi.org/10.1016/S0021-9258(17)41138-0
VESTLING, C. S. e KNOEPPELMACHER, A. A. — Lactic-dehidrogenase of liver and its relation to thyroide activity in the rat. J. Biol. Biochem., 183: 63, 1950. DOI: https://doi.org/10.1016/S0021-9258(18)56443-7
BIELCHOWSKY, F. — The role of hormonal factors in the development of tumors induced by 2-aminofluorene and related compounds. Acta. Inter, contra Cancrum, XVII: 121, 1961.
GRIFFIN, A. C., RINFRET A. P. e CORSIGLIA, V. F. — The inhibition of liver carcinogenesis with 3-methyl-4-dimethylaminoazobenzene in hypophysectomized rats. Câncer Res., 13: 77, 1953.
SYMEONIDES A., MULAY, A. S. e BURGOYNE, F. H. — Effect of adrenalectomy and of desoxicorticosterone acetate on the formation of liver lesions in rats fed p-dimethylaminoazo-benzene. J. Nat. Câncer Inst., 14: 805, 1954.
HOCH-LIGET, C. Effect of cortisone administration on induced and transplanted hepatomas. J. Nat. Cancer Inst., 15: 19663, 1955.
BIELCHOWSKY, F. e HALL, W. H. — Inhibition of the hepatoma inducing action of 2-amino and 2-acetylamino-fluorene by thyroidectomy. Proc. Univ. Otago med.'sch., 30: 26, 1952.
MILLER, W. L. e BAUMAN, C. A. — Basal metabolic rate and' liver tumors dué to'‘'azo-dyes. Cafícér Res., 11: 634, 1951.
RUMSFELD, H. W., MILLER, W. L. e BAUMAN, C. A. — A sex diference ih the development of livers tumors in rats fed 3-methyl-4-dymethylaminoa-zobenzene of 4-flüoro-4-dimethylami-noazobenzene. Câncer Res., 11: 814, 1951
LEATHEM,''J. H. — Influence of sex on 2-acetylaminofluorene-induced liver tumors in rats and mice. Câncer Res., 11: 266, 1951.
MORRIS, H. P. DUHNIK, c. s. e JOHNSON, J. M, Studies On the carcinogenic action in the rat of 2-nitro, 2-amino, 2-acetylamino and 2-diacetylaminofluorene after ingestion and after painting. J. Nat. Cancer Inst. 1: 1201, 1950.
FARBER, E., KOCH WESER, D. e POPPER, H. — The influence of sex and testosterone on fatty liver due to ethionine. Endodrinology, 48: 205, 1951. DOI: https://doi.org/10.1210/endo-48-2-205
BIELCHOWSKY, F. e BIELCHOWSKY, M. — Carcinogenesis in the pituitary dwarf mouse. The response to 2-ami-nofluorene. Brit, J. Câncer, 14: 195, 1960. DOI: https://doi.org/10.1038/bjc.1960.23
JACOBY, W. - Uber das rhytmische wachstern der Zelleu durch Verdoppelung ihres volumens. Arch. f. Entwck-lugsmech. d. Organ, 106: 124, 1925. DOI: https://doi.org/10.1007/BF02079531
POGO, A. O. POGO, B. G. T. e CORDERO — FUNNES, J. R. Corelation between desoxiribonucleic acid and volume in liver cells nuclei during potnatal growth. Exptl. Cell. Res., 20: 208. 1960. DOI: https://doi.org/10.1016/0014-4827(60)90237-8
SWARTZ, F. J. — The development in the human liver of multiple deoxiribose nucleic acid (DNA) classes and their relationship to the age of the individual. Chromosoma, 8: 53, 1956. DOI: https://doi.org/10.1007/BF01259493
STENRAM, V. — Nucleolus sizes in the liver of rats fed ou high and non-protein diets after starvation.. Acta Anatômica,,26: 352, 1956 DOI: https://doi.org/10.1159/000141108
--WILSON, J.W- Hepatomâs produced in mice by feeding bentonite in the diet. Annals of the New York Academy of Sciences, 57: 678/ 1954 DOI: https://doi.org/10.1111/j.1749-6632.1954.tb36444.x
FARBER, E. — Similarities in the sequence, of early histological changes induced ,in the liver of the rat by ethionine, 2-acetylaminofluorene, a 3-methyl-4dimmethylaminoazobeno. Cancer Res., 16: 142, 1956.
BULL, L. B. e DICK, A. T. – The chronic pathological effects on the liver of the rato f the pyrolizidine, and their N-oxides. J. Path. Bact.., 78: 483, 1959. DOI: https://doi.org/10.1002/path.1700780215
SCHOENTAL, R. e MAGEE, P. N. – Chronic liver changes in rats after a single dose of lasiocarpine, a pyrrolizidine (senécio) alkaloid. J. Path. Bact. 74; 305, 1957. DOI: https://doi.org/10.1002/path.1700740208
SCHOENTAL, R. e MAGEE, P. N. — Further observation on the subacute and chronic liver changes in rats after a single dose of varius pynolizidine (senécio) alkaloids. J. Path. Bact., 78; 471, 1959. DOI: https://doi.org/10.1002/path.1700780213
GUIMARÃES, J. P. — Lamerton, L. F. e CHRISTENSEN, W. R. — The late effects of thorotrast administration. A review and an experimental study. Brit. J. Câncer, 9; 253, 1955. DOI: https://doi.org/10.1038/bjc.1955.22
GUIMARÃES, J. P., LAMERTON, L. F. — Further observations on the late effects of thorotrast administration Brit. J. Câncer, 9; 527, 1956. DOI: https://doi.org/10.1038/bjc.1956.61
GUIMARÃES, J. P. morfológico dos efeitos do ouro radioativo (Aui98) sôbre o parênquima hepático. O Hospital, 63; 201, 1963.
HAREL, J., GUERIN, M., TUBIANA, J. e ABBATUCCI, J. — Production des tumeurs malignes (hepatomes et autres) par injections Intraperitoniales d’or radioactif chez le rat blanc. Bulletin F.p. etude du câncer, 43; 423, 1956.
CHRISTIE, G. S. e LE PAGE, R. N.— Enlargement of liver cell nuclei; effect of dimethylnitrosamine on size and desoxyribose nucleic acid content. Lab. Investigat. 10; 729, 1961.
ALFERT, M., GESCHWIND, L. I. — The development of polysomaty in rat li ver. Exptl. Cell Res., 15; 230, 1958. DOI: https://doi.org/10.1016/0014-4827(58)90079-X
DISTEFANO, H. S. e DIERMEIER, H. F. — Effects of hypohysectomy and growth hormone on ploidy distribution and mitotic activity of rat liver. Proc. Soc. Exp. Biol. Med., 92; 590, 1956. DOI: https://doi.org/10.3181/00379727-92-22553
CARRIÉRE, R., LEBLOND, C. P. e MESSIER, B. — Increase in the size of liver cell nuclei before mitosis. Exptl. Cell. Res., 23; 625, 1961. DOI: https://doi.org/10.1016/0014-4827(61)90025-8
HIMES, M., HCFFMAN, N. J., POLLISTER, A. W. e POST, J. — Origins of popyploid nuclei in rat liver during regeneration following carbon tetrachloride poisoning. J. Mt. Sinai Hosp., 24; 935, 1957.
GESCHWIND, II., ALFERT, M. e SCHOOLEY, C. Liver regeneration and hepatic polyploidy in the hypophysectomized rat. Exptl. Cell. Res., 15; 232, 1958. DOI: https://doi.org/10.1016/0014-4827(58)90080-6
SPAIN, J. D. — A histochemical study of glycogen alterations in the liver of rats following azo-dye administration. Cancer Res., 17; 3, 1957.
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.