Câncer Avançado da Mama: Conduta de Tratamento

Autores

  • Celso Werneck Ribeiro Chefe da unidade de Mastopatias Funcionantes. Assistente do Instituto Nacional de Câncer. Serviço Nacional de Câncer. Rio de Janeiro (RJ), Brasil

DOI:

https://doi.org/10.32635/2176-9745.RBC.1967v23n33.4057

Palavras-chave:

Neoplasias da Mama/terapia, Neoplasias da Mama/radioterapia, Neoplasias da Mama/cirurgia, Metástase Neoplásica, Terapia de Reposição Hormonal, Antineoplásicos, Hipofisectomia, Preparações Farmacêuticas

Resumo

A autor inicialmente define câncer avançado da mama, discutindo a seguir as diversas formas de tratamento. Em relação ao tratamento cirúrgico, contra-indica as operações radicais, esquematizando as de caráter paliativo. Considera a radioterapia, como o melhor tratamento para as metástases isoladas, havendo entretanto outras indicações em que seu emprego é justificado. Ressalta a importância do tratamento geral da paciente visando à correção dos desvios carenciais e metabólicos oriundos da presença do tumor. Na terapêutica hormonal. são comentados separadamente, as modalidades supressiva e aditiva, expondo o autor igualmente, os novos critérios de dependência, baseados na determinação de sexo morfológico nuclear das células tumorais. Finalizando, discute o emprego dos quimioterápicos, com breve comentário sobre as substâncias atualmente empregadas.

Downloads

Não há dados estatísticos.

Referências

ADAIR, F. — Câncer of the breast “Surgical clinics of North America” 33: 313, 1953- Ed. Saunders - Philadelphia. DOI: https://doi.org/10.1016/S0039-6109(16)33881-6

ADAIR, F. — Use of Estrogens and Androgens in Advanced Mamary Câncer. Jama 140: 1193, 1949. DOI: https://doi.org/10.1001/jama.1949.02900500001001

AMERICAN CÂNCER SOCIETY — Facts and Figures, 1960.

ATKINS, H. — Comparison and results of Adrenalectomy and hipophysectomy in Endocrine Aspects of Breast Câncer — Livingstone, Edinburgh.

BINNIE, G. C. Regression of Tumors Following Treatment with Stilbestrol and X — Ray notes on a Case of Breast tumour which Regressed ith Stilboestrol Alone. Brit J. Radiol 17: 42, 1944. DOI: https://doi.org/10.1259/0007-1285-17-194-42

BRENNAN, M. J., VAITKEVICIUS, V. K. — Clinical Câncer Experience whith Fluorow in 155 Patiens. Câncer Chemoter 6: 8, 1960.

BRINKEY, D. M., KINGALEY — PILLERS, E. Treatmente of Advanced Carcinoma of Breast by Bilateral Oophorectomy and Prednisone. Lancet 1: 123, 1960. DOI: https://doi.org/10.1016/S0140-6736(60)90050-7

BUCALOSSI, P. GRATTAROLA, R. and CATANIA V. — L’attivita estrogena dopo ovaro surrennectomia in donne portractici di carcinoma avanzato della mammella Tumori. 43: 525, 1957. DOI: https://doi.org/10.1177/030089165704300508

BUCALOSSI, P., CATANIA V. MISSIROCHI, E. and ROMANINI, A. Radiosiderazione delia mammella. Tumori 46: 185, 1960. DOI: https://doi.org/10.1177/030089166004600204

BULBROOK, R., GREENwOOD, F. and WILLIANS, P. — Parallel Chemical and biological assays of urinary estrogens after adrenalectomy and hypophysectomy In Endocrine aspects of Breast Câncer, Livingstone, Edinburgh, 1958, page 181.

CATANIA, V., LADO P. — Lovarosurrenectomia e la radiosiderazione ipofisaria nel Cancro metastatizzato della mammella. Considerazioni sul comportamento degli Steroidi urinari Tumori. 47; 32, 1961. DOI: https://doi.org/10.1177/030089166104700104

CHU G. C. H. and col. — Management of Advanced Breast Carcinoma with Special Reference to Combined Radiation and Hormone Therapy. Amer J. Roetgen 77: 438, 1957.

CROOKE, C. A. — Urinary gonadotropinas In Endocrine aspects of breast câncer. Livingstone Edinburgh 1958, page 173.

CUTTER, M. — The treatment of Advanced Mammary Câncer with Estrogens. Surgery 26: 567, 1949.

DAO, T. L. Adrenalectomy for Mammary Câncer. Rev. Quart Surg Obst y Ginec. 17: 75, 1960.

DOODS, C. — Endocrinologiae Progressus In Endocrin. Colloquia. Ed. Comitê Médico Espana — Francia, Playa de Haio, May 1961.

DUCUING, J. — Statistiques et commentaires sur une série personnele de 1037 cas de cancers du sein 51 Congress Français de Chirurgie. Paris, 1948.

FARRONE, J. J. — Effect of Sex Hormones ou Sketal Metastases from Breast Carcinoma. Surgery 16: 141, 1944.

GESCHIKTER, C. — Diseases of the Breast. Ed. Lippicott — Philadelphia, 1947.

HOLLEB, A. I., LUCAS, J. C. Jr. — Palliative Intercaspulathoracic Ampution in Management of Breast Câncer Patient. Câncer, 12: 643, 1959. DOI: https://doi.org/10.1002/1097-0142(195907/08)12:4<643::AID-CNCR2820120403>3.0.CO;2-I

HORMONAL ALTERATIONS in the Palliative treatment of Advanced Breast Câncer Ed. Williams 8 — Wükins, Baltimore, 1955.

HUGGINS, C. and DAO, T. — Adrenalectomy and Aophorectomy in tretment of Advanced carcinoma of the breast Jama 151; 13338, 1953.

JESSIMAN, A., MATSON, D. and MOORE, F. — Hypophysectomy in the treatment of Breast Câncer New Eng. J. Med., 261: 1199, 1959. DOI: https://doi.org/10.1056/NEJM195912102612401

KAUFMAN R. J., ESCHER, B. C. — Rebound Regression; Improvement After Cessation of Additive Hormonal Treatment in Women with Advanced Mammary Carcinoma. Proc. Amer Ass Sancer Res. 3: 124, 1960.

KOFMAN, S., NAGAMANI. D., BUENGER, R. E., TAYLOR, S. G. — Use of Prednisolone in treatment of Disseminated Breast Câncer. Câncer, 11; 226 1958. DOI: https://doi.org/10.1002/1097-0142(195801/02)11:1<226::AID-CNCR2820110135>3.0.CO;2-S

KOFMAN, S., GARVIN, J. S., TAYLOR, S. G. — Treatmente of Cerebral Metastases from Breast Câncer with prednisolone. Jama 163: 1473, 1957. DOI: https://doi.org/10.1001/jama.1957.02970510039008

LEMON, H. M. — Prednisolone Therapy of Advanced Mammary Câncer. Câncer, 12: 93, 1959. DOI: https://doi.org/10.1002/1097-0142(195901/02)12:1<93::AID-CNCR2820120115>3.0.CO;2-I

LI, M. C., WITHMORE W. F. Jr., GOLBEY, R. y Grabstald, H. — Effects of Combined Drug Therapy on metastatic Câncer of Testis Jama 174: 1291, 1961. DOI: https://doi.org/10.1001/jama.1960.03030100059013

LUFT, R., OLINECRONA, R. — Hypophysectomy in man Experiences in metastatic Câncer of the Breast. Câncer 8: 261, 1955. DOI: https://doi.org/10.1002/1097-0142(1955)8:2<261::AID-CNCR2820080205>3.0.CO;2-7

MAC DONALD, I. — Current Concepts of Endocrine Ablative Procedures in Disseminated Mammary Carcinoma. Fourth National Câncer Conference, 1960.

MAGLI, G. B., col. — Pharmacological and Initial Therapeutic Observations on in Human Neoplasic Disease. Câncer 10: 1138, 1957. DOI: https://doi.org/10.1002/1097-0142(195711/12)10:6<1138::AID-CNCR2820100608>3.0.CO;2-K

PEARSON, O. H., col. — Use Of Hydrocortisone in Câncer. Amer New York Acad. Sci. 61: 353, 1955. DOI: https://doi.org/10.1111/j.1749-6632.1955.tb42489.x

PEARSON, O. H., RAY, B. S. — Hypophysectomy in Treatment of metastatic mammary carcinoma. Amer J. Surg 99: 544, 1960. DOI: https://doi.org/10.1016/0002-9610(60)90149-5

PEARSON, O. H. — Evaluation of endocrine therapy for advanced breast câncer Jama 154: 234, 1954. DOI: https://doi.org/10.1001/jama.1954.02940370046013

PERRAULT, M. — Etat actuel des therapeutiques hormoneles et anti-hormonales dans le traitment du câncer du sein et des ses metastases chez la femme. In Bilbert etc. Câncer: Les diagnosties cytologiques: le câncer du sein Ed. Masson, Paris, 1954.

PERRAULT, M. — L’hypophysectomie et câncer du sein. Presse Med. 61: 1639, 1953.

DANDHAL, T. H. — Surgical Aspects of Hormonal Treatmente of Câncer. Mod Med. 28: 132, 1960. DOI: https://doi.org/10.1177/002581726002800303

RAY, B. S., PEARSON, O. H. — Hypophysectomy in the treatment of Advanced câncer of the breast. Ann Sur 144: 394, 1956. DOI: https://doi.org/10.1097/00000658-195609000-00009

SANTOS-SILVA, M. Cancer de mama — Considerações Gerais e Orientação de Tratamento Paliativo. Rev. Brasileira de Cancerologia, 18: (23) 7-14, 1963. DOI: https://doi.org/10.32635/2176-9745.RBC.1963v18n23.3725

SEGALLOFF, A., YCOL — Hormonal Therapy in Câncer of Breast VI. Effects of ACTH and Cortisone on clinical Course and Hormonal Excretion. Câncer, 7: 331, 1954. DOI: https://doi.org/10.1002/1097-0142(195403)7:2<331::AID-CNCR2820070218>3.0.CO;2-Y

SERTORI, C.; PIZETTI, F. and CATANIA V. — Studio istologico and intochimico del surreni e delle ovaie in pazienti portatrici de carcinoma mamario. Tumori 44: 263, 1958. DOI: https://doi.org/10.1177/030089165804400401

STRONG — The place of hormone assay in human breast Câncer in Endocrine aspects of breast Câncer. Livingstone Edinburgh, 1958, page 141.

TAN, C. T. C., col. — Clinical Experinence with Actinomycins D., K. S. 2, and Fl. (KS4). Ann N. Y. Acad. Sci. 89: 426, 1960. DOI: https://doi.org/10.1111/j.1749-6632.1960.tb20167.x

TREVES, N., FINKBEINER, J. A. — Evaluation of Therapeutic Surgical Castration in Treatment of Metastatic Recurrent, and Primará Inoperable Mammary Carcinoma in Women. Cancer, 11: 421, 1958. DOI: https://doi.org/10.1002/1097-0142(195803/04)11:2<421::AID-CNCR2820110226>3.0.CO;2-L

TREVES, N. Evaluation of Prophylatic Castration in Treatment of Mammary Carcinoma. Câncer, 10: 393, 1957. DOI: https://doi.org/10.1002/1097-0142(195703/04)10:2<393::AID-CNCR2820100223>3.0.CO;2-T

U. S. DEPARTMENT OF HEALTH and WELFARE — Morbidity from Cancer in the United Sstates, Public Health Monogr. 56, 1959.

WATNE, A. L., col. — Clinical studies with Actinomycin, D: Ann N. Y. Acad. Sci., 89, 445, 1960. DOI: https://doi.org/10.1111/j.1749-6632.1960.tb20168.x

WATSONG. W. TURNER R. L. — Breast Câncer, A. new Approach to Therapy Brit. Med. J., 1: 1315, 1959. DOI: https://doi.org/10.1136/bmj.1.5133.1315

Downloads

Publicado

2023-08-21

Como Citar

1.
Ribeiro CW. Câncer Avançado da Mama: Conduta de Tratamento. Rev. Bras. Cancerol. [Internet]. 21º de agosto de 2023 [citado 2º de novembro de 2024];23(33):93-108. Disponível em: https://rbc.inca.gov.br/index.php/revista/article/view/4057

Edição

Seção

ARTIGO ORIGINAL