Crioterapia no Manejo da Alopecia Induzida por Quimioterapia: Revisão Integrativa

Autores

DOI:

https://doi.org/10.32635/2176-9745.RBC.2024v70n2.4587

Palavras-chave:

Tratamento Farmacológico, Alopecia, Crioterapia/métodos, Revisão

Resumo

Introdução: A quimioterapia é atualmente um dos tratamentos mais utilizados contra o câncer, porém, por possuir ação sistêmica, acarreta diversos efeitos colaterais, entre os quais, a alopecia, que impacta na autoimagem e consequentemente na autoestima do paciente oncológico. Visando prevenir esse efeito adverso, a crioterapia capilar passou a ser utilizada como uma opção terapêutica. Objetivo: Analisar o conhecimento científico produzido sobre o uso da crioterapia para prevenir alopecia decorrente de quimioterapia. Método: Revisão integrativa da literatura realizada nas bases de dados MEDLINE, PubMed, IBECS e no catálogo de teses e dissertações da CAPES, com os descritores cold therapy, hair loss, scalp cooling, cryotherapy, alopecia e chemotherapy, no período de janeiro de 2015 a janeiro de 2023. Resultados: Dezoito estudos foram selecionados com base nos critérios de inclusão e exclusão. A crioterapia capilar é considerada eficaz na prevenção da alopecia grau 2, além de mostrar benefícios relacionados à velocidade de crescimento capilar após alopecia induzida por quimioterapia (AIQ), porém a técnica não mostrou bons resultados na população negra analisada. Os efeitos adversos mais comuns da técnica são cefaleia, algia mandibular e calafrios. Conclusão: O uso da técnica mostra-se como boa conduta para prevenir a AIQ em indivíduos em tratamento para tumores sólidos em razão da sua segurança e eficácia, porém, ainda são necessárias mais pesquisas em indivíduos de raça negra, por causa da discrepância na taxa de sucesso, visando contemplar todas as raças e curvaturas capilares.

Downloads

Não há dados estatísticos.

Referências

Instituto Nacional de Câncer José Alencar Gomes da Silva. ABC do câncer: abordagens básicas para o controle do câncer [Internet]. 6. ed. rev. Atual. Rio de janeiro: INCA; 2020. [acesso em 2024 jan 15]. Disponível em: https://www.inca.gov.br/sites/ufu.sti.inca.local/files//media/document/livro_abc_6ed_0.pdf

Leite MAC, Nogueira DA, Terra FS. Evaluation of self-esteem in cancer patients undergoing chemotherapy treatment. Rev Lat Am Enfermagem. 2015;23(6):1082-9. doi: https://doi.org/10.1590%2F0104-1169.0575.2652 DOI: https://doi.org/10.1590/0104-1169.0575.2652

Silva LCA, Signor AC, Pilati ACL, et al. abordagem educativa ao paciente oncológico: estratégias para orientação acerca do tratamento quimioterápico. Rev Bras Cancerol. 2019;65(1):e-06305. doi: https://doi.org/10.32635/2176-9745.RBC.2019v65n1.305 DOI: https://doi.org/10.32635/2176-9745.RBC.2019v65n1.305

Rugo HS, Voigt J. Scalp hypothermia for preventing alopecia during chemotherapy. a systematic review and meta-analysis of randomized controlled trials. Clin Breast Cancer. 2018;18(1):19-28. doi: https://doi.org/10.1016/j.clbc.2017.07.012 DOI: https://doi.org/10.1016/j.clbc.2017.07.012

Kang D, Kim I, Choi E, et al. Permanent chemotherapyinduced alopecia in patients with breast cancer: a 3‐year prospective cohort study. Oncologist. 2019;24(3):414-20. doi: https://doi.org/10.1634%2Ftheoncologist.2018-0184 DOI: https://doi.org/10.1634/theoncologist.2018-0184

National Cancer Institutes [Internet]. Washington, D.C: NCI; 2010. FDA Clears Wider Use of Cooling Cap to Reduce Hair Loss during Chemotherapy. 2017 jul 21. [acesso 2024 jan]. Disponível em: https://www.cancer.gov/news-events/cancer-currents-blog/2017/fda-coolingcap-chemotherapy

Page MJ, Moher D, Bossuyt PM, et al. Prisma 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews. BMJ. 2021;372:n160. doi: https://doi.org/10.1136/bmj.n160 DOI: https://doi.org/10.1136/bmj.n160

Bajpai J, Kagwade S, Chandrasekharan A, et al. “Randomised controlled trial of scalp cooling for the prevention of chemotherapy induced alopecia”. The Breast. 2020;49:187-93. doi: https://doi.org/10.1016/j.breast.2019.12.004 DOI: https://doi.org/10.1016/j.breast.2019.12.004

Munzone E, Bagnardi V, Campennì G, et al. Preventing chemotherapy-induced alopecia: a prospective clinical trial on the efficacy and safety of a scalp-cooling system in early breast cancer patients treated with anthracyclines. Br J Cancer. 2019;121(4):325-31. doi: https://doi.org/10.1038/s41416-019-0520-8 DOI: https://doi.org/10.1038/s41416-019-0577-4

Mitric C, How B, Matanes E, et al. Scalp cooling for reducing alopecia in gynecology oncology patients treated with dose-dense chemotherapy: a pilot project. Gynecol Oncol Rep. 2021;37:100842. doi: https://doi.org/10.1016%2Fj.gore.2021.100842 DOI: https://doi.org/10.1016/j.gore.2021.100842

Dilawari A, Gallagher C, Alintah P, et al. Does scalp cooling have the same efficacy in black patients receiving chemotherapy for breast cancer? Oncologist. 2021;26(4):292-e548. DOI: https://doi.org/10.1002/onco.13690

Kate S, Patil R, Pathan D, et al. Safety and efficacy of scalp cooling system in preventing chemotherapy induced alopecia - a single center prospective study. Cancer Treat Res Commun. 2021;26:100280. doi: https://doi.org/10.1016/j.ctarc.2020.100280 DOI: https://doi.org/10.1016/j.ctarc.2020.100280

Kinoshita T, Nakayama T, Fukuma E, et al. Efficacy of scalp cooling in preventing and recovering from chemotherapy-induced alopecia in breast cancer patients: the HOPE study. Front Oncol. 2019;9:733. doi: https://doi.org/10.3389/fonc.2019.00733 DOI: https://doi.org/10.3389/fonc.2019.00733

Lugtenberg RT, van den Hurk CJG, Smorenburg CH, et al. Comparable effectiveness of 45- and 20-min postinfusion scalp cooling time in preventing paclitaxelinduced alopecia — a randomized controlled trial. Suppor Care Cancer. 2022;30(8):6641-8. doi: https://doi.org/10.1007/s00520-022-07090-7 DOI: https://doi.org/10.1007/s00520-022-07090-7

Carbognin L, Accetta C, Giorgio D, et al. Prospective study investigating the efficacy and safety of a scalp cooling device for the prevention of alopecia in women undergoing (Neo)adjuvant chemotherapy for breast cancer. Curr Oncol. 2022;29(10):7218-28. doi: https://doi.org/10.3390/curroncol29100569 DOI: https://doi.org/10.3390/curroncol29100569

Brunner C, Emmelheinz M, Kofler R, et al. Hair safe study: effects of scalp cooling on hair preservation and hair regrowth in breast cancer patients receiving chemotherapy - a prospective interventional study. Breast. 2022;64:50-5. doi: https://doi.org/10.1016/j.breast.2022.04.008 DOI: https://doi.org/10.1016/j.breast.2022.04.008

Ohsumi S, Kiyoto S, Takahashi M, et al. Prospective study of hair recovery after (neo)adjuvant chemotherapy with scalp cooling in Japanese breast cancer patients. Support Care Cancer. 2021;29(10):619-25. doi: https://doi.org/10.1007%2Fs00520-021-06168-y DOI: https://doi.org/10.1007/s00520-021-06168-y

Bitto FF, König A, Phan-Brehm T, et al. EVA-Scalp: evaluation of patient satisfaction with a scalp cooling device to prevent chemotherapy-induced alopecia in breast cancer patients. Breast Care (Basel). 2019;15(2):1-7. doi: https://doi.org/10.1159%2F000501393 DOI: https://doi.org/10.1159/000501393

Gianotti E, Razzini G, Bini M, et al. Scalp cooling in daily clinical practice for breast cancer patients undergoing curative chemotherapy: a multicenter interventional study. Asia Pac J Oncol Nurs. 2019;6(3):277. doi: https://doi.org/10.4103/apjon.apjon_4_19 DOI: https://doi.org/10.4103/apjon.apjon_4_19

Saad M, Alip A, Chong FT, et al. The efficacy and tolerability of scalp cooling in preventing chemotherapyinduced alopecia in patients with breast cancer receiving anthracycline and taxane-based chemotherapy in an Asian setting. Indian J Cancer. 2018;55(2):157-61. doi: https://doi.org/10.4103/ijc.ijc_581_17 DOI: https://doi.org/10.4103/ijc.IJC_581_17

Fehr MK, Welter J, Sell W, et al. Sensor-controlled scalp cooling to prevent chemotherapy-induced alopecia in female cancer patients. Curr Oncol. 2016;23(6):576. doi: https://doi.org/10.3747%2Fco.23.3200 DOI: https://doi.org/10.3747/co.23.3200

Rugo HS, Melin SA, Voigt J. Scalp cooling with adjuvant/neoadjuvant chemotherapy for breast cancer and the risk of scalp metastases: systematic review and meta-analysis. Breast Cancer Res Treat. 2017;163(2):199-205. doi: https://doi.org/10.1007/s10549-017-4185-9 DOI: https://doi.org/10.1007/s10549-017-4185-9

Belum VR, Barros Silva G, Laloni MT, et al. Cold thermal injury from cold caps used for the prevention of chemotherapy-induced alopecia. Breast Cancer Res Treat. 2016;157(2):395-400. doi: https://doi.org/10.1007%2Fs10549-016-3799-7 DOI: https://doi.org/10.1007/s10549-016-3799-7

Keim S, Hempel L, Ebner F, et al. Scalp cooling for prevention of chemotherapy-induced alopecia for women and men with various cancer entities: a twoyears survey of an outpatient cancer center in Germany. Oncol Res Treat. 2022;45(7-8):395-9. doi: https://doi.org/10.1159/000523759 DOI: https://doi.org/10.1159/000523759

Monteiro DE. Resultados da crioterapia capilar na redução da alopecia em pacientes com câncer de mama em tratamento quimioterápico [dissertação]. Niterói: Universidade Federal Fluminense; 2021. [acesso 2023 jan 23]. Disponível em: https://app.uff.br/riuff/handle/1/23393

National Institutes of Health. Common Terminology Criteria for Adverse Events (CTCAE). Version 4.0. Washington, D.C: NIH/NCI; 2010. [acesso 2023 out 14]. Disponível em: https://evs.nci.nih.gov/ftp1/CTCAE/CTCAE_4.03/CTCAE_4.03_2010-06-14_QuickReference_8.5x11.pdf

Instituto Nacional de Câncer José Alencar Gomes da Silva. Estimativa 2023: Incidência de Câncer no Brasil. Rio de Janeiro: Instituto Nacional de Câncer José Alencar Gomes da Silva; 2022.

Publicado

2024-06-03

Como Citar

1.
Santana NCS de, Góes Ângela CF. Crioterapia no Manejo da Alopecia Induzida por Quimioterapia: Revisão Integrativa. Rev. Bras. Cancerol. [Internet]. 3º de junho de 2024 [citado 23º de dezembro de 2024];70(2):e-094587. Disponível em: https://rbc.inca.gov.br/index.php/revista/article/view/4587

Edição

Seção

REVISÃO DE LITERATURA