Cryotherapy in the Management of Chemotherapy-Induced Alopecia: Integrative Review

Authors

DOI:

https://doi.org/10.32635/2176-9745.RBC.2024v70n2.4587

Keywords:

Drug Therapy, Alopecia, Cryotherapy/methods, Review

Abstract

Introduction: Chemotherapy is currently one of the most widely used cancer treatments; however, its systemic action leads to various side effects, including alopecia, which impacts the self-image and consequently the self-esteem of oncology patients. In an effort to prevent this adverse effect, scalp cryotherapy has emerged as a therapeutic option. Objective: To analyze the scientific knowledge produced on the use of cryotherapy to prevent chemotherapy-induced alopecia. Method: Integrative literature review conducted on the MEDLINE, PubMed, IBECS databases, and on the catalog of CAPES theses and dissertations, utilizing the descriptors “cold therapy”, “hair loss”, “scalp cooling”, “cryotherapy”, “alopecia” and “chemotherapy” from January 2015 to January 2023. Results: Eighteen studies were selected based on inclusion and exclusion criteria. Scalp cryotherapy is considered effective in preventing grade 2 alopecia and shows benefits related to the speed of hair growth post chemotherapy-induced alopecia (CIA). However, the technique did not yield good results for the black population analyzed. The most common adverse effects of the technique are headache, mandibular pain, and chills. Conclusion: The use of the technique has proven to be a good conduct to prevent CIA in individuals undergoing treatment for solid tumors due to its safety and effectiveness. However, further research is needed in black individuals due to the discrepancy in success rates, aiming to encompass all races and hair textures.

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References

Instituto Nacional de Câncer José Alencar Gomes da Silva. ABC do câncer: abordagens básicas para o controle do câncer [Internet]. 6. ed. rev. Atual. Rio de janeiro: INCA; 2020. [acesso em 2024 jan 15]. Disponível em: https://www.inca.gov.br/sites/ufu.sti.inca.local/files//media/document/livro_abc_6ed_0.pdf

Leite MAC, Nogueira DA, Terra FS. Evaluation of self-esteem in cancer patients undergoing chemotherapy treatment. Rev Lat Am Enfermagem. 2015;23(6):1082-9. doi: https://doi.org/10.1590%2F0104-1169.0575.2652 DOI: https://doi.org/10.1590/0104-1169.0575.2652

Silva LCA, Signor AC, Pilati ACL, et al. abordagem educativa ao paciente oncológico: estratégias para orientação acerca do tratamento quimioterápico. Rev Bras Cancerol. 2019;65(1):e-06305. doi: https://doi.org/10.32635/2176-9745.RBC.2019v65n1.305 DOI: https://doi.org/10.32635/2176-9745.RBC.2019v65n1.305

Rugo HS, Voigt J. Scalp hypothermia for preventing alopecia during chemotherapy. a systematic review and meta-analysis of randomized controlled trials. Clin Breast Cancer. 2018;18(1):19-28. doi: https://doi.org/10.1016/j.clbc.2017.07.012 DOI: https://doi.org/10.1016/j.clbc.2017.07.012

Kang D, Kim I, Choi E, et al. Permanent chemotherapyinduced alopecia in patients with breast cancer: a 3‐year prospective cohort study. Oncologist. 2019;24(3):414-20. doi: https://doi.org/10.1634%2Ftheoncologist.2018-0184 DOI: https://doi.org/10.1634/theoncologist.2018-0184

National Cancer Institutes [Internet]. Washington, D.C: NCI; 2010. FDA Clears Wider Use of Cooling Cap to Reduce Hair Loss during Chemotherapy. 2017 jul 21. [acesso 2024 jan]. Disponível em: https://www.cancer.gov/news-events/cancer-currents-blog/2017/fda-coolingcap-chemotherapy

Page MJ, Moher D, Bossuyt PM, et al. Prisma 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews. BMJ. 2021;372:n160. doi: https://doi.org/10.1136/bmj.n160 DOI: https://doi.org/10.1136/bmj.n160

Bajpai J, Kagwade S, Chandrasekharan A, et al. “Randomised controlled trial of scalp cooling for the prevention of chemotherapy induced alopecia”. The Breast. 2020;49:187-93. doi: https://doi.org/10.1016/j.breast.2019.12.004 DOI: https://doi.org/10.1016/j.breast.2019.12.004

Munzone E, Bagnardi V, Campennì G, et al. Preventing chemotherapy-induced alopecia: a prospective clinical trial on the efficacy and safety of a scalp-cooling system in early breast cancer patients treated with anthracyclines. Br J Cancer. 2019;121(4):325-31. doi: https://doi.org/10.1038/s41416-019-0520-8 DOI: https://doi.org/10.1038/s41416-019-0577-4

Mitric C, How B, Matanes E, et al. Scalp cooling for reducing alopecia in gynecology oncology patients treated with dose-dense chemotherapy: a pilot project. Gynecol Oncol Rep. 2021;37:100842. doi: https://doi.org/10.1016%2Fj.gore.2021.100842 DOI: https://doi.org/10.1016/j.gore.2021.100842

Dilawari A, Gallagher C, Alintah P, et al. Does scalp cooling have the same efficacy in black patients receiving chemotherapy for breast cancer? Oncologist. 2021;26(4):292-e548. DOI: https://doi.org/10.1002/onco.13690

Kate S, Patil R, Pathan D, et al. Safety and efficacy of scalp cooling system in preventing chemotherapy induced alopecia - a single center prospective study. Cancer Treat Res Commun. 2021;26:100280. doi: https://doi.org/10.1016/j.ctarc.2020.100280 DOI: https://doi.org/10.1016/j.ctarc.2020.100280

Kinoshita T, Nakayama T, Fukuma E, et al. Efficacy of scalp cooling in preventing and recovering from chemotherapy-induced alopecia in breast cancer patients: the HOPE study. Front Oncol. 2019;9:733. doi: https://doi.org/10.3389/fonc.2019.00733 DOI: https://doi.org/10.3389/fonc.2019.00733

Lugtenberg RT, van den Hurk CJG, Smorenburg CH, et al. Comparable effectiveness of 45- and 20-min postinfusion scalp cooling time in preventing paclitaxelinduced alopecia — a randomized controlled trial. Suppor Care Cancer. 2022;30(8):6641-8. doi: https://doi.org/10.1007/s00520-022-07090-7 DOI: https://doi.org/10.1007/s00520-022-07090-7

Carbognin L, Accetta C, Giorgio D, et al. Prospective study investigating the efficacy and safety of a scalp cooling device for the prevention of alopecia in women undergoing (Neo)adjuvant chemotherapy for breast cancer. Curr Oncol. 2022;29(10):7218-28. doi: https://doi.org/10.3390/curroncol29100569 DOI: https://doi.org/10.3390/curroncol29100569

Brunner C, Emmelheinz M, Kofler R, et al. Hair safe study: effects of scalp cooling on hair preservation and hair regrowth in breast cancer patients receiving chemotherapy - a prospective interventional study. Breast. 2022;64:50-5. doi: https://doi.org/10.1016/j.breast.2022.04.008 DOI: https://doi.org/10.1016/j.breast.2022.04.008

Ohsumi S, Kiyoto S, Takahashi M, et al. Prospective study of hair recovery after (neo)adjuvant chemotherapy with scalp cooling in Japanese breast cancer patients. Support Care Cancer. 2021;29(10):619-25. doi: https://doi.org/10.1007%2Fs00520-021-06168-y DOI: https://doi.org/10.1007/s00520-021-06168-y

Bitto FF, König A, Phan-Brehm T, et al. EVA-Scalp: evaluation of patient satisfaction with a scalp cooling device to prevent chemotherapy-induced alopecia in breast cancer patients. Breast Care (Basel). 2019;15(2):1-7. doi: https://doi.org/10.1159%2F000501393 DOI: https://doi.org/10.1159/000501393

Gianotti E, Razzini G, Bini M, et al. Scalp cooling in daily clinical practice for breast cancer patients undergoing curative chemotherapy: a multicenter interventional study. Asia Pac J Oncol Nurs. 2019;6(3):277. doi: https://doi.org/10.4103/apjon.apjon_4_19 DOI: https://doi.org/10.4103/apjon.apjon_4_19

Saad M, Alip A, Chong FT, et al. The efficacy and tolerability of scalp cooling in preventing chemotherapyinduced alopecia in patients with breast cancer receiving anthracycline and taxane-based chemotherapy in an Asian setting. Indian J Cancer. 2018;55(2):157-61. doi: https://doi.org/10.4103/ijc.ijc_581_17 DOI: https://doi.org/10.4103/ijc.IJC_581_17

Fehr MK, Welter J, Sell W, et al. Sensor-controlled scalp cooling to prevent chemotherapy-induced alopecia in female cancer patients. Curr Oncol. 2016;23(6):576. doi: https://doi.org/10.3747%2Fco.23.3200 DOI: https://doi.org/10.3747/co.23.3200

Rugo HS, Melin SA, Voigt J. Scalp cooling with adjuvant/neoadjuvant chemotherapy for breast cancer and the risk of scalp metastases: systematic review and meta-analysis. Breast Cancer Res Treat. 2017;163(2):199-205. doi: https://doi.org/10.1007/s10549-017-4185-9 DOI: https://doi.org/10.1007/s10549-017-4185-9

Belum VR, Barros Silva G, Laloni MT, et al. Cold thermal injury from cold caps used for the prevention of chemotherapy-induced alopecia. Breast Cancer Res Treat. 2016;157(2):395-400. doi: https://doi.org/10.1007%2Fs10549-016-3799-7 DOI: https://doi.org/10.1007/s10549-016-3799-7

Keim S, Hempel L, Ebner F, et al. Scalp cooling for prevention of chemotherapy-induced alopecia for women and men with various cancer entities: a twoyears survey of an outpatient cancer center in Germany. Oncol Res Treat. 2022;45(7-8):395-9. doi: https://doi.org/10.1159/000523759 DOI: https://doi.org/10.1159/000523759

Monteiro DE. Resultados da crioterapia capilar na redução da alopecia em pacientes com câncer de mama em tratamento quimioterápico [dissertação]. Niterói: Universidade Federal Fluminense; 2021. [acesso 2023 jan 23]. Disponível em: https://app.uff.br/riuff/handle/1/23393

National Institutes of Health. Common Terminology Criteria for Adverse Events (CTCAE). Version 4.0. Washington, D.C: NIH/NCI; 2010. [acesso 2023 out 14]. Disponível em: https://evs.nci.nih.gov/ftp1/CTCAE/CTCAE_4.03/CTCAE_4.03_2010-06-14_QuickReference_8.5x11.pdf

Instituto Nacional de Câncer José Alencar Gomes da Silva. Estimativa 2023: Incidência de Câncer no Brasil. Rio de Janeiro: Instituto Nacional de Câncer José Alencar Gomes da Silva; 2022.

Published

2024-06-03

How to Cite

1.
Santana NCS de, Góes Ângela CF. Cryotherapy in the Management of Chemotherapy-Induced Alopecia: Integrative Review. Rev. Bras. Cancerol. [Internet]. 2024 Jun. 3 [cited 2024 Jul. 22];70(2):e-094587. Available from: https://rbc.inca.gov.br/index.php/revista/article/view/4587

Issue

Section

LITERATURE REVIEW