Crioterapia en el Manejo de la Alopecia Inducida por Quimioterapia: Revisión Integradora

Autores/as

DOI:

https://doi.org/10.32635/2176-9745.RBC.2024v70n2.4587

Palabras clave:

Quimioterapia, Alopecia, Crioterapia/métodos, Revisión

Resumen

Introducción: La quimioterapia es actualmente uno de los tratamientos más utilizados contra el cáncer; sin embargo, debido a su acción sistémica, conlleva diversos efectos secundarios, entre los cuales se encuentra la alopecia, que impacta en la autoimagen y, consecuentemente, en la autoestima del paciente oncológico. Con el objetivo de prevenir este efecto adverso, la crioterapia capilar ha emergido como una opción terapéutica. Objetivo: Analizar el conocimiento científico producido sobre el uso de la crioterapia para prevenir la alopecia inducida por quimioterapia. Metodología: Se trata de una revisión integrativa de la literatura realizada en las bases de datos MEDLINE, PubMed, IBECS y en el catálogo de tesis y disertaciones de CAPEs, utilizando los descriptores “cold therapy”, “hair loss”, "scalp cooling", "cryotherapy", "alopecia" y "chemotherapy", en el período de enero de 2015 a enero de 2023. Resultados: Dieciocho estudios fueron seleccionados según criterios de inclusión y exclusión. La crioterapia capilar se considera efectiva en la prevención de la alopecia de grado 2, además de mostrar beneficios relacionados con la velocidad de crecimiento capilar post alopecia inducida por quimioterapia (AIQ); sin embargo, la técnica no mostró buenos resultados en la población negra analizada. Los efectos adversos más comunes de la técnica son dolor de cabeza, algia mandibular y escalofríos. Consideraciones finales: El uso de la técnica se muestra como una buena práctica para prevenir la AIQ en individuos en tratamiento para tumores sólidos debido a su seguridad y eficacia; no obstante, se necesitan más investigaciones en individuos de raza negra debido a la discrepancia en la tasa de éxito, con el objetivo de abarcar todas las razas y curvaturas capilares.

Descargas

Los datos de descargas todavía no están disponibles.

Citas

Instituto Nacional de Câncer José Alencar Gomes da Silva. ABC do câncer: abordagens básicas para o controle do câncer [Internet]. 6. ed. rev. Atual. Rio de janeiro: INCA; 2020. [acesso em 2024 jan 15]. Disponível em: https://www.inca.gov.br/sites/ufu.sti.inca.local/files//media/document/livro_abc_6ed_0.pdf

Leite MAC, Nogueira DA, Terra FS. Evaluation of self-esteem in cancer patients undergoing chemotherapy treatment. Rev Lat Am Enfermagem. 2015;23(6):1082-9. doi: https://doi.org/10.1590%2F0104-1169.0575.2652 DOI: https://doi.org/10.1590/0104-1169.0575.2652

Silva LCA, Signor AC, Pilati ACL, et al. abordagem educativa ao paciente oncológico: estratégias para orientação acerca do tratamento quimioterápico. Rev Bras Cancerol. 2019;65(1):e-06305. doi: https://doi.org/10.32635/2176-9745.RBC.2019v65n1.305 DOI: https://doi.org/10.32635/2176-9745.RBC.2019v65n1.305

Rugo HS, Voigt J. Scalp hypothermia for preventing alopecia during chemotherapy. a systematic review and meta-analysis of randomized controlled trials. Clin Breast Cancer. 2018;18(1):19-28. doi: https://doi.org/10.1016/j.clbc.2017.07.012 DOI: https://doi.org/10.1016/j.clbc.2017.07.012

Kang D, Kim I, Choi E, et al. Permanent chemotherapyinduced alopecia in patients with breast cancer: a 3‐year prospective cohort study. Oncologist. 2019;24(3):414-20. doi: https://doi.org/10.1634%2Ftheoncologist.2018-0184 DOI: https://doi.org/10.1634/theoncologist.2018-0184

National Cancer Institutes [Internet]. Washington, D.C: NCI; 2010. FDA Clears Wider Use of Cooling Cap to Reduce Hair Loss during Chemotherapy. 2017 jul 21. [acesso 2024 jan]. Disponível em: https://www.cancer.gov/news-events/cancer-currents-blog/2017/fda-coolingcap-chemotherapy

Page MJ, Moher D, Bossuyt PM, et al. Prisma 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews. BMJ. 2021;372:n160. doi: https://doi.org/10.1136/bmj.n160 DOI: https://doi.org/10.1136/bmj.n160

Bajpai J, Kagwade S, Chandrasekharan A, et al. “Randomised controlled trial of scalp cooling for the prevention of chemotherapy induced alopecia”. The Breast. 2020;49:187-93. doi: https://doi.org/10.1016/j.breast.2019.12.004 DOI: https://doi.org/10.1016/j.breast.2019.12.004

Munzone E, Bagnardi V, Campennì G, et al. Preventing chemotherapy-induced alopecia: a prospective clinical trial on the efficacy and safety of a scalp-cooling system in early breast cancer patients treated with anthracyclines. Br J Cancer. 2019;121(4):325-31. doi: https://doi.org/10.1038/s41416-019-0520-8 DOI: https://doi.org/10.1038/s41416-019-0577-4

Mitric C, How B, Matanes E, et al. Scalp cooling for reducing alopecia in gynecology oncology patients treated with dose-dense chemotherapy: a pilot project. Gynecol Oncol Rep. 2021;37:100842. doi: https://doi.org/10.1016%2Fj.gore.2021.100842 DOI: https://doi.org/10.1016/j.gore.2021.100842

Dilawari A, Gallagher C, Alintah P, et al. Does scalp cooling have the same efficacy in black patients receiving chemotherapy for breast cancer? Oncologist. 2021;26(4):292-e548. DOI: https://doi.org/10.1002/onco.13690

Kate S, Patil R, Pathan D, et al. Safety and efficacy of scalp cooling system in preventing chemotherapy induced alopecia - a single center prospective study. Cancer Treat Res Commun. 2021;26:100280. doi: https://doi.org/10.1016/j.ctarc.2020.100280 DOI: https://doi.org/10.1016/j.ctarc.2020.100280

Kinoshita T, Nakayama T, Fukuma E, et al. Efficacy of scalp cooling in preventing and recovering from chemotherapy-induced alopecia in breast cancer patients: the HOPE study. Front Oncol. 2019;9:733. doi: https://doi.org/10.3389/fonc.2019.00733 DOI: https://doi.org/10.3389/fonc.2019.00733

Lugtenberg RT, van den Hurk CJG, Smorenburg CH, et al. Comparable effectiveness of 45- and 20-min postinfusion scalp cooling time in preventing paclitaxelinduced alopecia — a randomized controlled trial. Suppor Care Cancer. 2022;30(8):6641-8. doi: https://doi.org/10.1007/s00520-022-07090-7 DOI: https://doi.org/10.1007/s00520-022-07090-7

Carbognin L, Accetta C, Giorgio D, et al. Prospective study investigating the efficacy and safety of a scalp cooling device for the prevention of alopecia in women undergoing (Neo)adjuvant chemotherapy for breast cancer. Curr Oncol. 2022;29(10):7218-28. doi: https://doi.org/10.3390/curroncol29100569 DOI: https://doi.org/10.3390/curroncol29100569

Brunner C, Emmelheinz M, Kofler R, et al. Hair safe study: effects of scalp cooling on hair preservation and hair regrowth in breast cancer patients receiving chemotherapy - a prospective interventional study. Breast. 2022;64:50-5. doi: https://doi.org/10.1016/j.breast.2022.04.008 DOI: https://doi.org/10.1016/j.breast.2022.04.008

Ohsumi S, Kiyoto S, Takahashi M, et al. Prospective study of hair recovery after (neo)adjuvant chemotherapy with scalp cooling in Japanese breast cancer patients. Support Care Cancer. 2021;29(10):619-25. doi: https://doi.org/10.1007%2Fs00520-021-06168-y DOI: https://doi.org/10.1007/s00520-021-06168-y

Bitto FF, König A, Phan-Brehm T, et al. EVA-Scalp: evaluation of patient satisfaction with a scalp cooling device to prevent chemotherapy-induced alopecia in breast cancer patients. Breast Care (Basel). 2019;15(2):1-7. doi: https://doi.org/10.1159%2F000501393 DOI: https://doi.org/10.1159/000501393

Gianotti E, Razzini G, Bini M, et al. Scalp cooling in daily clinical practice for breast cancer patients undergoing curative chemotherapy: a multicenter interventional study. Asia Pac J Oncol Nurs. 2019;6(3):277. doi: https://doi.org/10.4103/apjon.apjon_4_19 DOI: https://doi.org/10.4103/apjon.apjon_4_19

Saad M, Alip A, Chong FT, et al. The efficacy and tolerability of scalp cooling in preventing chemotherapyinduced alopecia in patients with breast cancer receiving anthracycline and taxane-based chemotherapy in an Asian setting. Indian J Cancer. 2018;55(2):157-61. doi: https://doi.org/10.4103/ijc.ijc_581_17 DOI: https://doi.org/10.4103/ijc.IJC_581_17

Fehr MK, Welter J, Sell W, et al. Sensor-controlled scalp cooling to prevent chemotherapy-induced alopecia in female cancer patients. Curr Oncol. 2016;23(6):576. doi: https://doi.org/10.3747%2Fco.23.3200 DOI: https://doi.org/10.3747/co.23.3200

Rugo HS, Melin SA, Voigt J. Scalp cooling with adjuvant/neoadjuvant chemotherapy for breast cancer and the risk of scalp metastases: systematic review and meta-analysis. Breast Cancer Res Treat. 2017;163(2):199-205. doi: https://doi.org/10.1007/s10549-017-4185-9 DOI: https://doi.org/10.1007/s10549-017-4185-9

Belum VR, Barros Silva G, Laloni MT, et al. Cold thermal injury from cold caps used for the prevention of chemotherapy-induced alopecia. Breast Cancer Res Treat. 2016;157(2):395-400. doi: https://doi.org/10.1007%2Fs10549-016-3799-7 DOI: https://doi.org/10.1007/s10549-016-3799-7

Keim S, Hempel L, Ebner F, et al. Scalp cooling for prevention of chemotherapy-induced alopecia for women and men with various cancer entities: a twoyears survey of an outpatient cancer center in Germany. Oncol Res Treat. 2022;45(7-8):395-9. doi: https://doi.org/10.1159/000523759 DOI: https://doi.org/10.1159/000523759

Monteiro DE. Resultados da crioterapia capilar na redução da alopecia em pacientes com câncer de mama em tratamento quimioterápico [dissertação]. Niterói: Universidade Federal Fluminense; 2021. [acesso 2023 jan 23]. Disponível em: https://app.uff.br/riuff/handle/1/23393

National Institutes of Health. Common Terminology Criteria for Adverse Events (CTCAE). Version 4.0. Washington, D.C: NIH/NCI; 2010. [acesso 2023 out 14]. Disponível em: https://evs.nci.nih.gov/ftp1/CTCAE/CTCAE_4.03/CTCAE_4.03_2010-06-14_QuickReference_8.5x11.pdf

Instituto Nacional de Câncer José Alencar Gomes da Silva. Estimativa 2023: Incidência de Câncer no Brasil. Rio de Janeiro: Instituto Nacional de Câncer José Alencar Gomes da Silva; 2022.

Publicado

2024-06-03

Cómo citar

1.
Santana NCS de, Góes Ângela CF. Crioterapia en el Manejo de la Alopecia Inducida por Quimioterapia: Revisión Integradora. Rev. Bras. Cancerol. [Internet]. 3 de junio de 2024 [citado 22 de julio de 2024];70(2):e-094587. Disponible en: https://rbc.inca.gov.br/index.php/revista/article/view/4587

Número

Sección

REVISIÓN DE LA LITERATURA