Funcionalidade de Indivíduos com Doença Oncológica Internados em Unidades de Terapia Intensiva

Autores

DOI:

https://doi.org/10.32635/2176-9745.RBC.2024v70n2.4605

Palavras-chave:

Estado Funcional, Neoplasias/complicações, Unidades de Terapia Intensiva, Deambulação Precoce, erviços de Fisioterapia

Resumo

Introdução: Indivíduos com câncer representam cerca de 20% de todas as admissões em unidades de terapia intensiva. A redução da
capacidade funcional é resultante do câncer e seus tratamentos e pode ser potencializada pela imobilização advinda neste setor. Objetivo: Analisar a funcionalidade de indivíduos com doença oncológica internados em unidades de terapia intensiva. Método: Estudo observacional de coorte prospectiva, no qual foram avaliados indivíduos com câncer, internados em unidades de terapia intensiva dentro de 24 horas da admissão e da alta quando esta ocorreu por meio da escala Perme. As condições sociodemográficas foram coletadas com a aplicação de um questionário e as informações clínicas obtidas do prontuário. Os dados foram analisados por estatística descritiva e inferencial. Foi aplicado o teste t para amostras pareadas e independentes. Para correlacionar as variáveis quantitativas, foi utilizado o teste de correlação de Pearson. Resultados: Foram incluídos 42 indivíduos com câncer em estado crítico, predominantemente homens e com média de idade de 62,86 anos. O principal tipo tumoral identificado foi no sistema gastrointestinal (40,5%). A ventilação mecânica foi indicativa de menor funcionalidade. Foram registradas associações significativas entre o tempo de internação e a funcionalidade na admissão e alta. O desfecho dos pacientes admitidos com menor funcionalidade foi o óbito. Ao comparar os resultados de admissão e alta, houve melhora significativa do estado funcional. Conclusão: Os indivíduos com câncer admitidos em unidades de terapia intensiva apresentaram melhora da funcionalidade durante a internação.

Downloads

Não há dados estatísticos.

Referências

Pastores SM. Critical care and oncology. Crit Care Clin. 2021;37(1):15-6. doi: https://doi.org/10.1016/j.ccc.2020.10.001

Schellongowski P, Sperr WR, Wohlfarth P, et al. Critically ill patients with cancer: chances and limitations of intensive care medicine: a narrative review. ESMO Open. 2016;1(5):1-18. doi: https://doi.org/10.1136/esmoopen-2015-000018

Martos-Benítez FD, Soto-García A, Gutiérrez-Noyola A. Clinical characteristics and outcomes of cancer patients requiring intensive care unit admission: a prospective study. J Cancer Res Clin Oncol. 2018;144(4):717-23. doi: https://doi.org/10.1007/s00432-018-2581-0

Wigmore TJ, Farquhar-Smith P, Lawson A. Intensive care for the cancer patient: unique clinical and ethical challenges and outcome prediction in the critically ill cancer patient. Best Pract Res Clin Anaesthesiol. 2013;27(4):527-43. doi: https://doi.org/10.1016/j.bpa.2013.10.002

Grusdat NP, Stäuber A, Tolkmitt M, et al. Routine cancer treatments and their impact on physical function, symptoms of cancer-related fatigue, anxiety, and depression. Support Care Cancer. 2022;30(5):3733-44. doi: https://doi.org/10.1007/s00520-021-06787-5

Sassoon CS, Zhu E, Caiozzo VJ. Assist-control mechanical ventilation attenuates ventilator-induced diaphragmatic dysfunction. Am J Respir Crit Care Med. 2004;170(6):626-32. doi: https://doi.org/10.1164/rccm.200401-042oc

Dantas CM, Silva PF, Siqueira FH, et al. Influência da mobilização precoce na força muscular periférica e respiratória em pacientes críticos. Rev Bras Ter Intensiva. 2012;24(2):173-8. doi: https://doi.org/10.1590/S0103-507X2012000200013

Costa RT, Zampieri FG, Caruso P. Performance status and acute organ dysfunction influence hospital mortality in critically ill patients with cancer and suspected infection: a retrospective cohort analysis. Rev Bras Ter Intensiva. 2021;33(2):298-303. doi: https://doi.org/10.5935/0103-507X.20210038

Zampieri FG, Romano TG, Salluh JI, et al. Trends in clinical profiles, organ support use and outcomes of patients with cancer requiring unplanned ICU admission: a multicenter cohort study. Intensive Care Med. 2021;47(2):170-79. doi: https://doi.org/10.1007/s00134-020-06184-2

Conselho Nacional de Saúde (BR). Resolução n° 466, de 12 de dezembro de 2012. Aprova as diretrizes e normas regulamentadoras de pesquisas envolvendo seres humanos. Diário Oficial da União, Brasília, DF. 2013 jun 13; Seção I:59.

Perme C, Nawa RK, Winkelman C. A tool to assess mobility status in critically ill patients: the Perme Intensive Care Unit Mobility Score. Methodist Debakey Cardiovasc J. 2014;10(1):41-9. doi: https://doi.org/10.14797/mdcj-10-1-41

SPSS®: Statistical Package for Social Science (SPSS)[Internet]. Versão 20.0. [Nova York]. International Business Machines Corporation. [acesso 2023 mar 9]. Disponível em: https://www.ibm.com/br-pt/spss?utm_content=SRCWW&p1=Search&p4=43700077515785492&p5=p&gclid=CjwKCAjwgZCoBhBnEiwAz35Rwiltb7s14pOSLocnooMOQh9qAL59IHVc9WP4ixhNTVMjenRp3-aEgxoCubsQAvD_BwE&gclsrc=aw.ds

Mishra P, Singh U, Pandey CM, et al. Application of student’s t-test, analysis of variance, and covariance. Ann Card Anaesth. 2019;22(4):407-11. doi: https://doi.org/10.4103/aca.aca_94_19

Schober P, Boer C, Schwarte LA. Correlation coefficients: appropriate use and interpretation. Anesth Analg. 2018;126(5):1763-8. doi: https://doi.org/10.1213/ANE.0000000000002864

Jemal A, Ward EM, Johnson CJ, et al. Annual report to the nation on the status of cancer, 1975-2014, featuring survival. J Natl Cancer Inst. 2017;109(9):1-22. doi: https://doi.org/10.1093/jnci/djx030

Torres VB, Vassalo J, Silva UV, et al. Outcomes in critically ill patients with cancer-related complications. PLoS One. 2016;11(10):e0164537. doi: https://doi.org/10.1371/journal.pone.0164537

Soares M, Lobo SM, Torelly AP, et al. Desfecho de pacientes com câncer internados em unidades de terapia intensiva brasileiras com lesão renal aguda. Rev Bras Ter Intensiva. 2010;22(3):236-44. doi: https://doi.org/10.1590/S0103-507X2010000300004

Azevedo LC, Park M, Salluh JI, et al. Clinical outcomes of patients requiring ventilatory support in Brazilian intensive care units: a multicenter, prospective, cohort study. Critical Care (Fullerton). 2013;17(2):63-76. doi: https://doi.org/10.1186/cc12594

Romano AM, Gade KE, Nielsen G, et al. Early palliative care reduces end‐of‐Life intensive care unit (ICU) use but not ICU course in patients with advanced cancer. Oncologist. 2017;22(3):318-23. doi: https://doi.org/10.1634/theoncologist.2016-0227

Jeong BH, Na SJ, Lee DS. Readmission and hospital mortality after ICU discharge of critically ill cancer patients. PLoS One. 2019;14(1):211-15. doi: https://doi.org/10.1371/journal.pone.0211240

Zheng B, Reardon PM, Fernando SM, et al. Costs and outcomes of patients admitted to the intensive care unit with cancer. J Intensive Care Med. 2020;36(2):203-10. doi: https://doi.org/10.1177/0885066619899653

Hsu SH, Campbell C, Weeks AK, et al. A pilot survey of ventilated cancer patients’ perspectives and recollections of early mobility in the intensive care unit. Support Care Cancer. 2019;28(2):747-53. doi: https://doi.org/10.1007/s00520-019-04867-1

Fane M, Weeraratna AT. How the ageing microenvironment influences tumour progression. Nat Rev Cancer. 2020;20(2):89-106. doi: https://doi.org/10.1038/s41568-019-0222-9

Nightingale G, Battisti NM, Loh KP, et al. Perspectives on functional status in older adults with cancer: An interprofessional report from the International Society of Geriatric Oncology (SIOG) nursing and allied health interest group and young SIOG. J Geriatr Oncol. 2021;12(4):658-65. doi: https://doi.org/10.1016/j.jgo.2020.10.018

Heo SJ, Kim G, Lee CK, et al. Prediction of short- and long-term survival for advanced cancer patients after ICU admission. Support Care Cancer. 2015;23(6):1647-55. doi: https://doi.org/10.1007/s00520-014-2519-2

Luna ECW, Perme C, Gastaldi AC. Relationship between potential barriers to early mobilization in adult patients during intensive care stay using the Perme ICU Mobility score. Can J Respir Ther. 2021;57(1):148-53. doi: https://doi.org/10.29390/cjrt-2021-018

Siegel RL, Miller KD, Fuchs HE, et al. Cancer statistics, 2022. CA Cancer J Clin. 2022;72(1):7-33. doi: https://doi.org/10.3322/caac.21708

Klein SL, Flanagan KL. Sex differences in immune responses. Nat Rev Immunol. 2016;16(10):626-38. doi: https://doi.org/10.1038/nri.2016.90

Haviland K, Tan KS, Schwenk N, et al. Outcomes after long-term mechanical ventilation of cancer patients. BMC Palliat Care. 2020;19(42):1-6. doi: https://doi.org/10.1186/s12904-020-00544-x

Pereira CS, Carvalho AT, Bosco AD, et al. The Perme scale score as a predictor of functional status and complications after discharge from the intensive care unit in patients undergoing liver transplantation. Rev Bras Ter Intensiva. 2019;31(1):57-62. doi: https://doi.org/10.5935/0103-507x.20190016

Timenetsky KT, Serpa Neto A, Lazarin AC, et al. The perme mobility index: a new concept to assess mobility level in patients with coronavirus (COVID-19) infection. PLoS One. 2021;16(4):1-15. doi: https://doi.org/10.1371/journal.pone.0250180

Nawa RK, Serpa Neto A, Lazarin AC, et al. Analysis of mobility level of COVID-19 patients undergoing mechanical ventilation support: a single center, retrospective cohort study. PLoS One. 2022;17(8):1-17. doi: https://doi.org/10.1371/journal.pone.0272373

Cabilan CJ, Hines S. The short-term impact of colorectal cancer treatment on physical activity, functional status and quality of life: a systematic review. JBI Database System Rev Implement Rep. 2017;15(2):517-66. doi: https://doi.org/10.11124/jbisrir-2016003282

Morishima T, Sato A, Nakata K, et al. Barthel Index-based functional status as a prognostic factor in young and middle-aged adults with newly diagnosed gastric, colorectal and lung cancer: a multicentre retrospective cohort study. BMJ Open. 2021;11(4):1-10. doi: https://doi.org/10.1136/bmjopen-2020-046681

Ronning B, Wyller TB, Jordhoy MS, et al. Frailty indicators and functional status in older patients after colorectal cancer surgery. J Geriatr Oncol. 2014;5(1):26-32. doi: https://doi.org/10.1016/j.jgo.2013.08.001

Grimer R, Athanasou N, Gerrand C, et al. UK guidelines for the management of bone sarcomas. Clin Sarcoma Res. 2010;2010(1):1-14. doi: https://doi.org/10.1186/s13569-016-0047-1

Krajewski S, Furtak J, Zawadka-Kunikowska M, et al. Comparison of the functional state and motor skills of patients after cerebral hemisphere, ventricular system, and cerebellopontine angle tumor surgery. Int J Environ Res Public Health. 2022;19(4):2308-22. doi: https://doi.org/10.3390/ijerph19042308

Druml W, Zajic P, Schellongowski P, et al. Association of acute kidney injury receiving kidney replacement therapy with prognosis of critically ill patients with and without cancer: a retrospective study. Crit Care Med. 2021;49(11):1932-42. doi: https://doi.org/10.1097/ccm.ccm.0000000000005102

Lameire N, Van Biesen W, Vanholder R. Acute renal problems in the critically ill cancer patient. Curr Opin Crit Care. 2008;14(6):635-46. doi: https://doi.org/10.1097/mcc.0b013e32830ef70b

AbuSara AK, Nazer LH, Hawari FI. ICU readmission of patients with cancer: incidence, risk factors and mortality. J Crit Care. 2019;51(1):84-7. doi: https://doi.org/10.1016/j.jcrc.2019.02.008

Puthucheary ZA, Rawal J, McPhail M, et al. Acute skeletal muscle wasting in critical illness. JAMA. 2013;310(15):1591-600. doi: https://doi.org/10.1001/jama.2013.278481

Vanhorebeek I, Latronico N, Van den Berghe G. ICU-acquired weakness. Intensive Care Med. 2020;46(4):637-53. doi: https://doi.org/10.1007/s00134-020-05944-4

Schweickert WD, Pohlman MC, Pohlman AS, et al. Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet. 2009;373(9678):1874-82. doi: https://doi.org/10.1016/s0140-6736(09)60658-9

Dubb R, Nydahl P, Hermes C, et al. Barriers and strategies for early mobilization of patients in intensive care units. Ann Am Thorac Soc. 2016;13(5):724-30. doi: https://doi.org/10.1513/annalsats.201509-586cme

Publicado

2024-06-25

Como Citar

1.
Käfer DC, Matos E de O de, de Cesaro D, Savaris M, Seger CA, Teixeira AC, Jorge MSG. Funcionalidade de Indivíduos com Doença Oncológica Internados em Unidades de Terapia Intensiva. Rev. Bras. Cancerol. [Internet]. 25º de junho de 2024 [citado 13º de dezembro de 2024];70(2):e-234605. Disponível em: https://rbc.inca.gov.br/index.php/revista/article/view/4605

Edição

Seção

ARTIGO ORIGINAL