Impact of Antineoplastic Treatment on Oral Cavity and Oropharyngeal Microbiota of Head and Neck Cancer Patients: Systematic Review
DOI:
https://doi.org/10.32635/2176-9745.RBC.2022v68n1.1581Keywords:
mouth neoplasms, head and neck neoplasms, microbiota, antineoplastic agentsAbstract
Introduction: A great diversity of microorganisms are found in the oral and oropharyngeal cavities, which are normally in homeostasis with other microorganisms and the host itself. Patients with head and neck cancer undergoing cancer treatment may trigger physiological changes in their bodies and impact in the resident microbiota. Objective: Systematically review studies on the impact of antineoplastic treatment on oral and oropharyngeal microbiota in patients with head and neck cancer. Method: Systematic review carried out between April and June 2020. Articles were searched in the Virtual Health Library, Google Scholar, PubMed and ScienceDirect databases in English, utilizing the descriptors “head and neck neoplasms”, “mouth neoplasms” and “microbiota” and “neoplasias de cabeca e pescoco”, “neoplasias bucais” and “microbiota” in Portuguese. Original articles available in full, published in the last decade (2010 to 2020), in Portuguese and English were selected. Results: 8 articles were included in this review. Most of studies have shown quantitative changes in resident microorganisms or invasion of exogenous bacteria in patients in antineoplastic treatment; uncontrolled microbiota homeostasis triggered cariogenic and inflammatory processes in the mucosa. Conclusion: Changes in the microbiome of the oral cavity and oropharyngeal resulting from antineoplastic treatment may be predisposing factors for adverse effects as the development of caries and oral mucositis.
Downloads
References
Colombo J, Rahal P. Alterações genéticas em câncer de cabeça e pescoço. Rev Bras Cancerol. 2009;55(2):165-74. doi: https://doi.org/10.32635/2176-9745.RBC.2009v55n2.1648
Instituto Nacional de Câncer José Alencar Gomes da Silva. Estimativa 2020: incidência de câncer no Brasil [Internet]. Rio de Janeiro: INCA; 2019 [acesso 2020 maio 25]. Disponível em: https://www.inca.gov.br/sites/ufu.sti.inca.local/files/media/document/estimativa-2020-incidencia-de-cancer-no-brasil.pdf
Instituto Nacional de Câncer José Alencar Gomes da Silva. Dia Nacional de Combate ao Câncer: estimativa 2016: incidência de câncer no Brasil [Internet]. Rio de Janeiro: INCA; 2015 [acesso 2020 maio 25]. Disponível em: http://www.oncoguia.org.br/pub//10_advocacy/Estimativas_INCA.pdf [Apresentação em Powerpoint].
Lee SC, Tang IP, Avatar SP, et al. Head and neck cancer: possible causes for delay in diagnosis and treatment. Med J Malaysia. 2011;66(2):101-4.
Lambert R, Sauvaget C, Camargo Cencela M, et al. Epidemiology of cancer from the oral cavity and oropharynx. Eur J Gastroenterol Hepatol. 2011;23(8):633-41. doi: https://doi.org/10.1097/MEG.0b013e3283484795
Chen T, Yu WH, Izard J. et al. The human oral microbiome database: a web accessible resource for investigating oral microbe taxonomic and genomic information. Database (Oxford). 2010;2010:baq013. doi: https://doi.org/10.1093/database/baq013
Sampaio-Maia B, Caldas IM, Pereira ML, et al. The oral microbiome in health and its implication in oral and systemic diseases. Adv Appl Microbiol. 2016;97:171‐210. doi: https://doi.org/10.1016/bs.aambs.2016.08.002
Jenkinson HF, Lamont RJ. Oral microbial communities in sickness and in health. Trends Microbiol. 2005;13(12):589-95. doi: https://doi.org/10.1016/j.tim.2005.09.006
Lemos JA, Palmer SR, Zeng L, et al. The Biology of Streptococcus mutans. Microbiol Spectr. 2019;7(1):GPP3-0051-2018. doi: https://doi.org/10.1128/microbiolspec.GPP3-0051-2018
Komiyama EY, Lepesqueur LSS, Yassuda CG, et al. Enterococcus species in the oral cavity: prevalence, virulence factors and antimicrobial susceptibility. PloS One. 2016;11(9):e0163001. doi: https://doi.org/10.1371/journal.pone.0163001
Leão-Vasconcelos LSNO, Lima ABM, Costa DM, et al. Enterobacteriaceae isolates from the oral cavity of workers in a Brazilian oncology hospital. Rev Inst Med Trop São Paulo. 2015;57(2):121‐7. doi: https://doi.org/10.1590/S0036-46652015000200004
Ghannoum MA, Jurevic RJ, Mukherjee PK, et al. Characterization of the oral fungal microbiome (Mycobiome) in healthy individuals. PLoS Pathog. 2010;6(1):e1000713. doi: https://doi.org/10.1371/journal.ppat.1000713
Moon JH, Lee J. Probing the diversity of healthy oral microbiome with bioinformatics approaches. BMB Rep. 2016;49(12):662-570. doi: https://doi.org/10.5483/bmbrep.2016.49.12.164
Costalonga M, Herzberg MC. The oral microbiome and the immunobiology of periodontal disease and caries. Immunol Lett. 2014;162(2 Pt A):22-38. doi: https://doi.org/10.1016/j.imlet.2014.08.017
Nasry B, Choong C, Flamiatos E, et al. Diversity of the oral microbiome and dental health and disease. Int J Clin Med Microbiol. 2016;1(1):1-8. doi: https://doi.org/10.15344/2456-4028/2016/108
Terai T, Okumura T, Imai S, et al. Screening of probiotic candidates in human oral bacteria for the prevention of dental disease. PLoS One. 2015;10(6):e0128657. doi: https://doi.org/10.1371/journal.pone.0128657
Kim BS, Han DH, Lee H, et al. Association of salivary microbiota with dental caries incidence with dentine involvement after 4 years. J Microbiol Biotechnol. 2018;28(3):454-64. doi: https://doi.org/10.4014/jmb.1710.10028
Instituto Latino Americano de Sepse [Internet]. São Paulo: Sepse; c2016. Santa Casa faz alerta à sociedade no Dia Mundial de Combate à Sepse; 2016 dez 6 [acesso 2020 jun 3]. Disponível em: https://ilas.org.br/interacao/?p=230
Galvão TF, Pereira MG. Revisões sistemáticas da literatura: passos para sua elaboração. Epidemiol Serv Saúde. 2014.;23(1):183-4. doi: http://doi.org/10.5123/S1679-49742014000100018
Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097. doi: http://doi.org/10.1371/journal.pmed.1000097
Ouzzani M, Hammady H, Fedorowicz Z, et al. Rayyan--a web and mobile app for systematic reviews. Syst Rev. 2016;5:210. doi: https://doi.org/10.1186/s13643-016-0384-4
Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209-49. doi: http://doi.org/10.3322/caac.21660
Muzic JG, Schmitt AR, Wright AC, et al. Incidence and trends of basal cell carcinoma and cutaneous squamous cell carcinoma: a population-based study in olmsted county, Minnesota, 2000 to 2010. Mayo Clin Proc. 2017;92(6):890‐8. doi: https://doi.org/10.1016/j.mayocp.2017.02.015
Curado MP, Hashibe M. Recent changes in the epidemiology of head and neck cancer. Curr Opin Oncol. 2009;21(3):194-200. doi: https://doi.org/10.1097/CCO.0b013e32832a68ca
Mougeot JC, Stevens CB, Almon KG, et al. Caries-associated oral microbiome in head and neck cancer radiation patients: a longitudinal study. J Oral Microbiol. 2019;11(1):1586421. doi: https://doi.org/10.1080/20002297.2019.1586421
Zhu XX, Yang XJ, Chao YL, et al. The potential effect of oral microbiota in the prediction of mucositis during radiotherapy for nasopharyngeal carcinoma. EBioMedicine. 2017;18:23‐31. doi: https://doi.org/10.1016/j.ebiom.2017.02.002
Souza FRN, Meca LB, Correia ASC, et al. Microrganismos oportunistas na boca de pacientes irradiados: avaliação de 12meses pós-tratamento. Arch Health Invest. 2015;4(5):55-61.
Vidal-Casariego A, Fernández-Natal I, Calleja-Fernández A, et al. Nutritional, microbiological, and therapeutic factors related to mucositis in head and neck cancer patients: a cohort study. Nutr Hosp. 2015;32(3):1208‐13. doi: https://doi.org/10.3305/nh.2015.32.3.9299
Hu YJ, Shao ZY, Wang Q, et al. Exploring the dynamic core microbiome of plaque microbiota during head-and-neck radiotherapy using pyrosequencing. PLoS One. 2013;8(2):e56343. doi: https://doi.org/10.1371/journal.pone.0056343
Gaetti-Jardim Jr E, Ciesielski FIN, Nunes de Sousa FR, et al. Occurrence of yeasts, pseudomonads and enteric bacteria in the oral cavity of patients undergoing head and neck radiotherapy. Braz J Microbiol. 2011;42(3):1047-55. doi: https://doi.org/10.1590/S1517-83822011000300024
Simões CA, Castro JFL, Cazal C. Candida Oral como fator agravante da mucosite radioinduzida. Rev Bras Cancerol. 2011;57(1):23-9. doi: https://doi.org/10.32635/2176-9745.RBC.2011v57n1.681
Dabas PS. An approach to etiology, diagnosis and management of different types of candidiasis. J Yeast Fungal Res. 2013;4(6):63-74. doi: https://doi.org/10.5897/JYFR2013.0113
Zhang J, Liu H, Liang X. et al. Investigation of salivary function and oral microbiota of radiation caries-free people with nasopharyngeal carcinoma. PLoS One. 2015;10(4):e0123137. doi: https://doi.org/10.1371/journal.pone.0123137
Published
How to Cite
Issue
Section
License
Os direitos morais e intelectuais dos artigos pertencem aos respectivos autores, que concedem à RBC o direito de publicação.
This work is licensed under a Creative Commons Attribution 4.0 International License.
