Evolution of the Nutritional status of Children and Adolescents with Acute Lymphoid Leukemia undergoing Cancer Therapy
DOI:
https://doi.org/10.32635/2176-9745.RBC.2022v68n2.1865Keywords:
precursor cell lymphoblastic leukemia-lymphoma/drug therapy, nutrition assessment, nutritional status, child, adolescentAbstract
Introduction: When it comes to childhood cancer, acute lymphoid leukemia (ALL) stands out due to its high prevalence in this population. Of all types of cancer affecting this population, children and adolescents seem to be more susceptible to adverse effects such as malnutrition and/or overweight during treatment. Objective: To evaluate the evolution of the nutritional status of children and adolescents with acute ALL undergoing cancer therapy. Method: Retrospective, longitudinal study with patients with ALL undergoing antineoplastic therapy carried out with 69 children and adolescents (up to 19 years old) of both sexes. Weight and height measurements were collected on eight different occasions throughout the treatment, the first at the beginning of the treatment and the last at the end of all the sessions of antineoplastic treatment. Results: At diagnosis, there was prevalence of patients classified as eutrophic. When the age group and the indicator of Height/Age for age were correlated, it was observed that children under 10 years old had lower values when compared to those older than 10 years during the treatment, in addition to a rising trend of the Weight/Age score slowly until its end. Conclusion: Patients undergoing antineoplastic treatment for ALL presented a reduction in the velocity of growth, in addition to a slight weight gain at the end of the therapy, which suggests a negative interference on the nutritional status of this population.
Downloads
References
American Cancer Society. Global cancer facts & figures [Internet]. 4th ed. Atlanta (GA): American Cancer Society; 2018 [cited 2020 Nov 15]. Available from: https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/global-cancer-facts-and-figures/global-cancer-facts-and-figures-4th-edition.pdf
Instituto Nacional de Câncer José Alencar Gomes da Silva. Estimativa 2020: incidência de câncer no Brasil [Internet]. Rio de Janeiro: INCA; 2019 [acesso 2020 setembro 19]. Disponível em: https://www.inca.gov.br/sites/ufu.sti.inca.local/files/media/document/estimativa-2020-incidencia-de-cancer-no-brasil.pdf
Seki Y, Okamoto Y, Kodama Y, et al. Risk factors and the prevention of weight gain during induction chemotherapy in children with acute lymphoblastic Leukemia. J Pediatr Hematol Oncol. 2018;40(6):e334-e337. doi: https://doi.org/10.1097/MPH.0000000000001098 DOI: https://doi.org/10.1097/MPH.0000000000001098
Orgel E, Genkinger JM, Aggarwal D, et al. Association of body mass index and survival in pediatric leukemia: a meta-analysis. Am J Clin Nutr. 2016;103(3):808-17. doi: https://doi.org/10.3945/ajcn.115.124586 DOI: https://doi.org/10.3945/ajcn.115.124586
Guler E, Col N, Buyukcelik M, et al. Prevalence of hypertension determined by ambulatory blood pressure monitoring (ABPM) and body composition in long-term survivors of childhood cancer. Pediatr Hematol Oncol. 2018;35(1):1-10. doi: https://doi.org/10.1080/08880018.2018.1425784 DOI: https://doi.org/10.1080/08880018.2018.1425784
Joffe L, Dwyer S, Glade Bender JL, et al. Nutritional status and clinical outcomes in pediatric patients with solid tumors: a systematic review of the literature. Semin Oncol. 2019;46(1):48-56. doi: https://doi.org/10.1053/j.seminoncol.2018.11.005 DOI: https://doi.org/10.1053/j.seminoncol.2018.11.005
Wędrychowicz A, Hull B, Tyrawa K, et al. Cushing disease in children and adolescents - assessment of the clinical course, diagnostic process, and effects of the treatment - experience from a single paediatric centre. Pediatr Endocrinol Diabetes Metab. 2019;25(3):127-43. doi: https://doi.org/10.5114/pedm.2019.87179 DOI: https://doi.org/10.5114/pedm.2019.87179
Vilela MIOP, Viana MB. Longitudinal growth and risk factors for growth deficiency in children treated for acute lymphoblastic leukemia. Pediatr Blood Cancer. 2007;48(1):86-92. doi: https://doi.org/10.1002/pbc.20901 DOI: https://doi.org/10.1002/pbc.20901
Bruzzi P, Bigi E, Predieri B, et al. Long-term effects on growth, development, and metabolism of ALL treatment in childhood. Expert Rev Endocrinol Metab. 2019;14(1):49-61. doi: https://doi.org/10.1080/17446651.2019.1561271 DOI: https://doi.org/10.1080/17446651.2019.1561271
World Health Organization. WHO child growth standards: length/height-for-age, weight-for-age, weight-for-length, weight-for-height and body mass index-for-age: methods and development. Geneva: WHO; 2006.
Conselho Nacional de Saúde (BR). Resolução nº 466, de 12 de dezembro de 2012. Aprova as diretrizes e normas regulamentadoras de pesquisas envolvendo seres humanos [Internet]. Diário Oficial da União, Brasília, DF. 2013 jun 13 [acesso 2021 out 2]; Seção 1:59. Disponível em: https://conselho.saude.gov.br/resolucoes/2012/Reso466.pdf
Laks D, Longhi F, Wagner MB, et al. Avaliação da sobrevida de crianças com leucemia linfocítica aguda tratadas com o protocolo Berlim-Frankfurt-Munique. J Pediatr (Rio J). 2003;79(2):149-58. doi: https://doi.org/10.1590/S0021-75572003000200010 DOI: https://doi.org/10.1590/S0021-75572003000200010
Revuelta Iniesta R, Paciarotti I, Davidson I, et al. Nutritional status of children and adolescents with cancer in Scotland: a prospective cohort study. Clin Nutr ESPEN. 2019;32:96-106. doi: https://doi.org/10.1016/j.clnesp.2019.04.006 DOI: https://doi.org/10.1016/j.clnesp.2019.04.006
Dudeja S, Gupta S, Sharma S, et al. Incidence of vincristine induced neurotoxicity in children with acute lymphoblastic leukemia and its correlation with nutritional deficiencies. Pediatr Hematol Oncol. 2019;36(6):344-51. doi: https://doi.org/10.1080/08880018.2019.1637981 DOI: https://doi.org/10.1080/08880018.2019.1637981
Oliveira BA, Lins MM, Pedrosa F, et al. Estado nutricional de crianças e adolescentes sobreviventes de leucemia linfoide aguda tratados em um Centro de Referência da Região Nordeste do Brasil. Rev Nutr. 2013;26(3):271-81. doi: https://doi.org/10.1590/S1415-52732013000300002 DOI: https://doi.org/10.1590/S1415-52732013000300002
Gomes CC, Silva CCG, Nascimento PRP, et al. Nutritional status and appetite-regulating hormones in early treatment of acute lymphoblastic leukemia among children and adolescents: a cohort study. Sao Paulo Med J. 2020;138(2):118-25. doi: https://doi.org/10.1590/1516-3180.2019.0307.r1.19112019 DOI: https://doi.org/10.1590/1516-3180.2019.0307.r1.19112019
Browne EK, Zhou Y, Chemaitilly W, et al. Changes in body mass index, height, and weight in children during and after therapy for acute lymphoblastic leukemia. Cancer. 2018;124(21):4248-59. doi: https://doi.org/10.1002/cncr.31736 DOI: https://doi.org/10.1002/cncr.31736
Collins L, Zarzabal LA, Nayiager T, et al. Growth in children with acute lymphoblastic leukemia during treatment. J Pediatr Hematol Oncol. 2010;32(8):e304-7. doi: https://doi.org/10.1097/MPH.0b013e3181ece2bb DOI: https://doi.org/10.1097/MPH.0b013e3181ece2bb
Arpe MLH, Rørvig S, Kok K, et al. The association between glucocorticoid therapy and BMI z-score changes in children with acute lymphoblastic leukemia. Support Care Cancer. 2015;23(12):3573-80. doi: https://doi.org/10.1007/s00520-015-2718-5 DOI: https://doi.org/10.1007/s00520-015-2718-5
Borim LNB, Ruiz MA, Conte ACF, et al. Estado nutricional como fator prognóstico em crianças portadoras de Leucemia Linfocítica Aguda. Rev Bras Hematol Hemoter. 2000;22(1):47-53. doi: https://doi.org/10.1590/S1516-84842000000100007 DOI: https://doi.org/10.1590/S1516-84842000000100007
Schmiegelow K, Attarbaschi A, Barzilai S, et al. Consensus definitions of 14 severe acute toxic effects for childhood lymphoblastic leukaemia treatment: a Delphi consensus. Lancet Oncol. 2016;17(6):e231-e239. doi: https://doi.org/10.1016/S1470-2045(16)30035-3 DOI: https://doi.org/10.1016/S1470-2045(16)30035-3
Koshimoto S, Arimoto M, Saitou K, et al. Need and demand for nutritional counselling and their association with quality of life, nutritional status and eating-related distress among patients with cancer receiving outpatient chemotherapy: a cross-sectional study. Support Care Cancer. 2019;27(9):3385-94. doi: https://doi.org/10.1007/s00520-018-4628-9 DOI: https://doi.org/10.1007/s00520-018-4628-9
den Hoed MAH, Pluijm SMF, de Groot-Kruseman HA, et al. The negative impact of being underweight and weight loss on survival of children with acute lymphoblastic leukemia. Haematologica. 2015;100(1):62-9. doi: https://doi.org/10.3324/haematol.2014.110668 DOI: https://doi.org/10.3324/haematol.2014.110668
Withycombe JS, Smith LM, Meza JL, et al. Weight change during childhood acute lymphoblastic leukemia induction therapy predicts obesity: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2015;62(3):434-9. doi: https://doi.org/10.1002/pbc.25316 DOI: https://doi.org/10.1002/pbc.25316
Published
How to Cite
Issue
Section
License
Os direitos morais e intelectuais dos artigos pertencem aos respectivos autores, que concedem à RBC o direito de publicação.
This work is licensed under a Creative Commons Attribution 4.0 International License.