Deferoxamine in the prophylaxis of experimentally induced actinic enteritis in rats

Abstract

The authors performed a study to evaluate the efficacy of Deferoxamine (DFX) in the prophylaxis of experimentally induced actinic enteritis in Wistar rats. Eight groups were used: I- Control, II- Sham, III- Radiation without DFX and sacrifice 15 hours after, IV- Radiation with DFX and sacrifice 15 hours after, V- Radiation without DFX and sacrifice 5 days after, VI- Radiation with DFX and sacrifice 5 days after, VII- Radiation without DFX and sacrifice 30 days after and VIII- Radiation with DFX and sacrifice 30 days after. The model, which groups III to VIII were submitted to, consisted in exposure of a segment of 10cm of ileus proximal to the ileal-cecal valve to 1.000cGy delivered by a cobalt source device. DFX (100mg per 1 kg of body weight) was given intraperitoneally one hour before radiation. Evaluation parameters were clinical (mortality), biochemical and histological (qualitative and quantitative). For statistical analysis the tests of Brieger and Tukey were used. Morphometry was normal in the30 day-after DFX group. The authors concluded that DFX was histologically efficient in the prophylaxis of actinic enteritis and attributed this to the capacity of DFX to decrease significantly early lipid peroxidation.