Quality of Life and Oral Health in Children undergoing Antineoplastic Therapy

Authors

DOI:

https://doi.org/10.32635/2176-9745.RBC.2022v68n2.2164

Keywords:

neoplasms, antineoplastic agents/adverse effects, oral manifestations, quality of life, child

Abstract

Introduction: Cancer is a burdensome disease whose treatment protocol can produce severe psychosocial and physical side effects. The main effects of antineoplastic treatment may affect the oral cavity, especially in children, compromising theirs and their family quality-of-life. Objective: To identify and describe side effects-related antineoplastic treatment and to assess its impact on the children’s and their families’ quality-of-life. Method: Qualitative and cross-sectional study, with the participation of 117 children, preschoolers, consulted at a referral hospital in the State of Paraíba, through the B-Ecohis questionnaire, dental clinical exams and medical records. The statistical treatment was based on descriptive analysis and Poisson Regression with robust variance in the Stepwise method (p<0.05). Results: The most common manifestations were mucositis and xerostomia (66.7% and 54.7% respectively). The impact on the children’s quality-of-life affected mostly the domain of functional limitation with mean of 3.0 (±1.8) and 1.0 (±1.0) for the family function in the family. Conclusion: The impact on the quality-of life in children was weak and not significant in the family.

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References

Instituto Nacional de Câncer José Alencar Gomes da Silva. Estimativa 2020: incidência de câncer no Brasil. Rio de Janeiro: INCA; 2019.

Goursand D, Borges CM, Alves KM, et al. Sequelas bucais em crianças submetidas à terapia antineoplásica: causas e definição do papel do cirurgião dentista. Arqu Odontol [Internet]. 2006 [acesso 2020 jul 11];42(3):161-256. Disponível em: https://periodicos.ufmg.br/index.php/arquivosemodontologia/article/view/3402

Barbosa AM, Ribeiro DM, Caldo-Teixeira AS. Conhecimentos e práticas em saúde bucal com crianças hospitalizadas com câncer. Ciênc Saúde Coletiva. 2010;15(Suppl 1):1113-22. doi: https://doi.org/10.1590/S1413-81232010000700019

Fraga GGAS, Macêdo DP, Jácome Júnior AT, et al. Aparecimento de manifestações orais em crianças ocasionadas pelo uso de terapias antineoplásicas. In: Castro LHA, Moreto FVC, Pereira TT, organizadores. Ações de saúde e geração de conhecimento nas ciências médicas 7. Ponta Grossa (PR): Atena; 2020. p. 92-100. doi: https://doi.org/10.22533/at.ed.02920230712 DOI: https://doi.org/10.22533/at.ed.02920230712

Tesch FC, Oliveira BH, Leão A. Equivalência semântica da versão em português do instrumento Early Childhood Oral Health Impact Scale. Cad Saúde Pública. 2008;24(8):1897-1909. doi: https://doi.org/10.1590/S0102-311X2008000800018 DOI: https://doi.org/10.1590/S0102-311X2008000800018

Martins-Júnior PA, Ramos-Jorge J, Paiva SM, et al. Validations of the Brazilian version of the Early Childhood Oral Health Impact Scale (ECOHIS). Cad Saúde Pública. 2012;28(2):367-74. doi: https://doi.org/10.1590/S0102-311X2012000200015 DOI: https://doi.org/10.1590/S0102-311X2012000200015

Conselho Nacional de Saúde (BR). Resolução nº 466, de 12 de dezembro de 2012. Aprova as diretrizes e normas regulamentadoras de pesquisas envolvendo seres humanos. Diário Oficial da União, Brasília, DF. 2013 jun 13; Seção 1:59.

Makvandi P, Josic U, Delfi M, et al. Drug Delivery (Nano) platforms for oral and dental applications: tissue regeneration, infection control, and cancer management. Adv Sci (Weinh). 2021;8(8):2004014. doi: https://doi.org/10.1002/advs.202004014 DOI: https://doi.org/10.1002/advs.202004014

Wogelius P, Rosthøj S, Dahllöf G, et al. Oral health-related quality of life among survivors of childhood cancer. Int J Paediatr Dent. 2011;21(6):465-7. doi: https://doi.org/10.1111/j.1365-263X.2011.01134.x DOI: https://doi.org/10.1111/j.1365-263X.2011.01134.x

Barbosa AM, Ribeiro DM, Caldo-Teixeira AS. Conhecimentos e práticas em saúde bucal com crianças hospitalizadas com câncer. Ciênc Saúde Coletiva. 2010;15(Suppl 1):1113-22. doi: https://doi.org/10.1590/S1413-81232010000700019 DOI: https://doi.org/10.1590/S1413-81232010000700019

Paredes SO, Galvão RN, Fonseca FRA. Influência da saúde bucal sobre a qualidade de vida de crianças pré-escolares. Rev Baiana Saúde Pública. 2014;38(1):125-39. doi: https://doi.org/10.22278/2318-2660.2014.v38.n1.a649 DOI: https://doi.org/10.22278/2318-2660.2014.v38.n1.a649

Villa A, Sonis ST. Mucositis: pathobiology and management. Curr Opin Oncol. 2015;27(3):159-64. doi: https://doi.org/10.1097/CCO.0000000000000180 DOI: https://doi.org/10.1097/CCO.0000000000000180

Ribeiro ILA, Melo ACR, Limão NP, et al. Oral mucositis in pediatric oncology patients: a nested case-control to a prospective cohort. Braz Dent J. 2020;31(1):78-88. doi: https://doi.org/10.1590/0103-6440201802881 DOI: https://doi.org/10.1590/0103-6440201802881

Gordón-Nuñez MA, Pinto LP. Candidíase e sua relação com a mucosite oral em pacientes oncológicos pediátricos. Rev Bras Patol Oral. 2003;2(2):4-9.

Damascena LCL, Lucena NNN, Ribeiro ILA, et al. Severe oral mucositis in pediatric cancer patients: survival analysis and predictive factors. Int J Environ Res Public Health. 2020;17(4):1235. doi: https://doi.org/10.3390/ijerph17041235 DOI: https://doi.org/10.3390/ijerph17041235

Amaral TMP, Campos CC, Santos TPM, et al. Effect of salivary stimulation therapies on salivary flow and chemotherapy-induced mucositis: a preliminary study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;113(5):628-37. doi: https://doi.org/10.1016/j.oooo.2011.10.012 DOI: https://doi.org/10.1016/j.oooo.2011.10.012

Lopes-Júnior LC, Bomfim EO, Nascimento LC, et al. Non-pharmacological interventions to manage fatigue and psychological stress in children and adolescents with cancer: an integrative review. Eur J Cancer Care (Engl). 2016;25(6):921-5. doi: https://doi.org/10.1111/ecc.12381 DOI: https://doi.org/10.1111/ecc.12381

Lopes IA, Nogueira DN, Lopes IA. Manifestações orais decorrentes da quimioterapia em crianças de um centro de tratamento oncológico. Pesq Bras Odontoped Clin Integr. 2012;12(1):113-9. DOI: https://doi.org/10.4034/PBOCI.2012.121.18

Jesus LG, Cicchelli M, Martins GB, et al. Repercussões orais de drogas antineoplásicas: uma revisão de literatura. RFO UPF. 2016;21(1):130-5. doi: https://doi.org/10.5335/rfo.v21i1.5052 DOI: https://doi.org/10.5335/rfo.v21i1.5052

Alves RF, Melo MO, Andrade SFO, et al. Qualidade de vida em pacientes oncológicos na assistência em casas de apoio. Aletheia. 2012;38(39):39-54.

Del Bianco Faria AM, Cardoso CL. Aspectos psicossociais de acompanhantes cuidadores de crianças com câncer: stress e enfrentamento. Estud Psicol. 2010;27(1):13-20. doi: https://doi.org/10.1590/S0103-166X2010000100002 DOI: https://doi.org/10.1590/S0103-166X2010000100002

Van der Gucht K, Takano K, Labarque V, et al. A mindfulness-based intervention for adolescents and young adults after cancer treatment: effects on quality of life, emotional distress, and cognitive vulnerability. J Adolesc Young Adult Oncol. 2017;6(2):307-17. doi: https://doi.org/10.1089/jayao.2016.0070 DOI: https://doi.org/10.1089/jayao.2016.0070

Velez-Florez G, Velez-Florez MC, Mantilla-Rivas JO, et al. Mind-body therapies in childhood cancer. Curr Psychiatry Rep. 2018;20(8):58. doi: https://doi.org/10.1007/s11920-018-0927-6 DOI: https://doi.org/10.1007/s11920-018-0927-6

Ponte YO, Ximenes RDA, Vasconcelos AA, et al. Saúde bucal em crianças com câncer: conhecimentos e práticas dos cuidadores. RFO UPF. 2019;24(2):183-91. doi: https://doi.org/10.5335/rfo.v24i2.10433 DOI: https://doi.org/10.5335/rfo.v24i2.10433

Published

2022-06-22

How to Cite

1.
Lima AKMMN de, Paulo AC, Duarte DA. Quality of Life and Oral Health in Children undergoing Antineoplastic Therapy. Rev. Bras. Cancerol. [Internet]. 2022 Jun. 22 [cited 2024 Jul. 22];68(2):e-202164. Available from: https://rbc.inca.gov.br/index.php/revista/article/view/2164

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Section

ORIGINAL ARTICLE