Comparison of Mortality in Patients with Cancer Undergoing Invasive and Non-Invasive Ventilation: Retrospective Cohort Study
DOI:
https://doi.org/10.32635/2176-9745.RBC.2022v68n3.2466Keywords:
neoplasms/mortality, respiratory insufficiency, respiration, artificial, noninvasive ventilationAbstract
Introduction: Cancer patients have a high prevalence of acute respiratory failure (ARF) related to complications of cancer treatment. Mechanical ventilatory support is the main therapy to resolve this complication. However, this procedure/intervention can increase mortality. Objective: To investigate the mortality rate and intervening factors of cancer patients with ARF exposed to invasive (IMV) and non-invasive mechanical ventilation (NIV). Method: Retrospective cohort study. 121 cancer patients on mechanical ventilation were enrolled divided into groups: IMV in patients with hematological neoplasms (IMVHN, n=17), NIV in hematological neoplasms (NIVHN, n=36), IMV in solid neoplasms (IMVSN, n=39) and NIV in solid neoplasms (NIVSN, n=29). The outcomes evaluated were: mortality rate, length of stay, time of exposure to mechanical ventilation, NIV failure rate and factors related to NIV failure. Results: The overall mortality rate was 47.9%, distributed in IMVHN (82.4%), NIVHN (27.8%), IMVSN (69.2%) and NIVSN (24.1%). A high APACHE III score was associated with a higher mortality rate. The mortality rate associated with NIV failure was 71.4% IMVHN and 77.8% NIVSN. The variables associated with the highest NIV failure rate were APACHE III>17 and NIV exposure time>72 hours. Conclusion: The mortality rate of patients with hematologic and solid neoplasm in ARF was lower in patients exposed to NIV.
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