Progressive Premalignant and Malignant Development (Metachronous Appearance) in Multiple Burn Sears (Marjolm’s Ulcers) Report of a Rare Case and Review of the Literature

Authors

  • Horácio M. Scigliano Departamento de Ciências Morfo-Biológicas (DCMB). Universidade Federal do Rio Grande (FURG). Rio Grande (RS). Brasil.
  • Romeu Ferreira Daroda Departamento de Ciências Morfo-Biológicas (DCMB). Universidade Federal do Rio Grande (FURG). Rio Grande (RS). Brasil.
  • Marco Antônio da Silva Pereira Departamento de Ciências Morfo-Biológicas (DCMB). Universidade Federal do Rio Grande (FURG). Rio Grande (RS). Brasil.
  • Marisa I. Suarez Departamento de Ciências Morfo-Biológicas (DCMB). Universidade Federal do Rio Grande (FURG). Rio Grande (RS). Brasil.
  • Mareia Ferreira Daroda Departamento de Ciências Morfo-Biológicas (DCMB). Universidade Federal do Rio Grande (FURG). Rio Grande (RS). Brasil.

DOI:

https://doi.org/10.32635/2176-9745.RBC.1999v45n3.2782

Keywords:

Carcinoma, Squamous Cell Carcinoma, Bums, Skin Neoplasms, Skin Ulcers

Abstract

The eponym Marjolin’s ulcer is used to describe the malignant transformation of any skin ulcer or scar. A 35-year-old white woman sustained a thermal bum injury over her lower half of the body when she was 8 years old. After 16 years of the event and over 9 years, metaehronous skin ulcers, pseudocarcinomatous hyperplasia and well differentiated squamous cell carcinomas occured, mainly on both lower limbs. The clinical history, histologic aspects, histogenesis, follow-up data and therapeutic considerations are discussed along with a review of the relevant literature.

Downloads

Download data is not yet available.

References

Fleming, M.D.; Hunt, J.L.; Perdue, G.F.; Sandstad, J. Marjolin’s ulcer: a review and reevaluation of a difficult problem. J. Burn CareRehabil., 11: 460-469, 1990. DOI: https://doi.org/10.1097/00004630-199009000-00016

Fishman, J.R.; Parker, M.G. Malignancy and chronic wounds: Marjolin’s ulcer. J. Bum Gare Rehabil., 12: 218-223, 1991. DOI: https://doi.org/10.1097/00004630-199105000-00004

Barr, L.H.; Menard, J.W. Marjolin’s ulcer. TheLSU experience. Câncer, 52: 173-175, 1983. DOI: https://doi.org/10.1002/1097-0142(19830701)52:1<173::AID-CNCR2820520131>3.0.CO;2-6

Clairmont, A.A.; Hanna, D.C.; Gaisford, J.C.; Richardson, G.S. Marjolin’s ulcer. Penn. Med., 82: 31-33, 1979.

Steffen, C. Marjolin’s ulcer. Report of two cases and evidence that Marjolin did not describe caneer arising in scars of burns. Am. J. Dermatopathol., 6: 187-193, 1984. DOI: https://doi.org/10.1097/00000372-198404000-00015

Sedlin, E.D.; Fleming, J.L. Epidermoid car cinoma arising in Chronic osteomyelitis foci. J. Bone Joint Surg., 45: 827-832,1963. DOI: https://doi.org/10.2106/00004623-196345040-00017

Murphy, G.F.; Mihm, M.C. The skin. In: Cotran, R.S.; Kumar, V.; Robbins, S.L. Robbins pathological basis of disease. 5th ed. Philadelphia. WB Saunders, 1173-1211, 1984.

Hahn, S.B.; Kim, D.J.; Jeon, C.H. Clinical study of MarjoIi’s ulcer. Yonsei Med. J., 31:234-241, 1990. DOI: https://doi.org/10.3349/ymj.1990.31.3.234

Kirham, N. Tumors and cysts of the epidermis. In: Elder, D.; Elenitsas, R.; Jaworsky, C.; Johnson, B. Lever’s Histopathology of the skin. 8th ed. Philadelphia. Lippincott-Raven, 685-746, 1997.

Clements, B.; Lewis, H.; Lewis, H.; Mckinstrey, S.; Cray, J.; Byrnes, D. A late, fatal complication of a high energy thermal injury to the scalp. Ann. Plast. Surg., 35: 650-653, 1995. DOI: https://doi.org/10.1097/00000637-199512000-00016

Türegün, M.; Nisanci, M.; Güler, M. Burn scar carcinoma with longer lag period arising in previously grafted area. Burns, 23: 496-497, 1997. DOI: https://doi.org/10.1016/S0305-4179(97)00041-7

Kim, J.M.; Su, W.P.; Kurtin, P.J.; Ziesmer, S. Marjolin’s ulcer: immunohistochemical study of 17 cases and comparision with common squamous cell carcinoma and basal cell carcinoma. J. Cutan. Pathol., 19: 278-285, 1992. DOI: https://doi.org/10.1111/j.1600-0560.1992.tb01363.x

Alcolado, J.C.; Ray, K.; Baxter, M.; Edwards, C.W.; Dodson, P.M. Malignant change in dermatitis artefacta. Postgrad. Med. J., 69: 648-650, 1993. DOI: https://doi.org/10.1136/pgmj.69.814.648

Rahimizadeh, A.; Shelton, R.; Weinberg, H.; Sadick, N. The development of Marjolin’s câncer in a human immunodeficiency virus-positive hemophilic man and review of the literature. Dermatol. Surg., 23: 560-563, 1997. DOI: https://doi.org/10.1111/j.1524-4725.1997.tb00687.x

Bernstein, S.C.; Lim, K.K.; Brodland, D.G.; Heidelberg, K.A. The many faces of squa mous cell carcinoma. Dermatol. Surg., 22: 243-254, 1996. DOI: https://doi.org/10.1111/j.1524-4725.1996.tb00315.x

Goldberg, N.S.; Robinson, J.K.; Peterson, C. Gigantic malignant melanoma in a thermal burn scar. J. Am. Acad. Dermatol., 12: 949-952, 1985. DOI: https://doi.org/10.1016/S0190-9622(85)70120-X

Marjolin, J.N. Cours de Pathologie Chirurgical. Paris. 1837. 18- Olewiler, S.D. Marjolin’s ulcer due to venous stasis. Cutis, 56: 168-170, 1995.

Olewiler, S.D. Marjolin’s ulcer due to venous stasis. Cutis, 56: 168-170, 1995.

Hill, B.B.; Sloan,D.A.; Lee,E.Y.; McGrath, P.C.; Kenady, D.E. Marjolin’s ulcer of the foot caused by nonburn trauma. S. Med. J., 89: 707-710, 1996. DOI: https://doi.org/10.1097/00007611-199607000-00011

Schoeman, B.J. Squamous cell carcinoma in neuropathic plantar ulcers in leprosy: another example of Marjolin’s ulcer. S. Afr. Med., 86: 966-969, 1996.

Berkwits, L.; Yarkony, G.M.; Lewis, V. Marjolin’s ulcer complicating a pressure ulcer. Archiv. Physical Med. Rehab., 67: 831-833, 1986.

Stankard, C.E.; Cruse, C.W.; Wells, K.E.; Karl, R. Chronic pressure ulcer carcinomas. Ann. Plast. Surg., 30: 274-277, 1993. DOI: https://doi.org/10.1097/00000637-199303000-00014

Nkere, U.U.; Banjar, A. Malignant change in a chronic skin lesion induced by an intravenous cannula. Postgrad. Med. J., 73 :45-47, 1997. DOI: https://doi.org/10.1136/pgmj.73.855.45

Ames, P.C.; Hickey, R.C. Squamous cell carcinoma of the skin of the extremities. Int. Adv. Surg. OncoL, 3: 179-199, 1980.

Mosborg, D.A.; Grane, R.T.; Tami, T.A.; Parker, G.S. Burn scar carcinoma of the head and neck. Arch. Otolaryngol. Head Neck Surg., 114: 1038-1040, 1988. DOI: https://doi.org/10.1001/archotol.1988.01860210104027

Celikõz, B.; Demiriz, M.; Selmanpakoglu, N. A shorter lag period of mesenchymal malignancy on Marjolin’s ulcer. Burns, 23: 72-74, 1997. DOI: https://doi.org/10.1016/S0305-4179(96)00026-5

Hoxtell, E.O.; Mandell, J.S.; Murray, S.S. et al. Incidence of skin carcinoma after renal transplantation. Arch. Dermatol., 133: 436-441, 1977. DOI: https://doi.org/10.1001/archderm.1977.01640040044005

Alves, J.C.R. Aspectos da patologia da cicatrização. In: Mélega, J.M.; Zanini, A.S.; Psillakis, J.M. Cirurgia Plástica Reparadora e Estética. Rio de Janeiro, Ed. Medsi, 15-21, 1988.

Ryan, R.E.; Litwin, M.S.; Krementz, E.T. A new comcept in the manegement of Marjolin’s ulcer. Ann. Surg., 193:598-605, 1981. DOI: https://doi.org/10.1097/00000658-198105000-00009

Ryan, R.E.; Krementz, E.T.; Litwin, M.S. A role for topical 5-Eluorouracil therapy in melanoma. J. Surg. Oncol., 38:250-256, 1988. DOI: https://doi.org/10.1002/jso.2930380409

Iregbuken, L.M. Post-burn squamous cell cancers in Nigerians. Br. J. Plast. Surg., 40: 488-493, 1987. DOI: https://doi.org/10.1016/S0007-1226(87)90078-6

Published

2022-09-21

How to Cite

1.
Scigliano HM, Daroda RF, Pereira MA da S, Suarez MI, Daroda MF. Progressive Premalignant and Malignant Development (Metachronous Appearance) in Multiple Burn Sears (Marjolm’s Ulcers) Report of a Rare Case and Review of the Literature. Rev. Bras. Cancerol. [Internet]. 2022 Sep. 21 [cited 2024 May 14];45(3):39-44. Available from: https://rbc.inca.gov.br/index.php/revista/article/view/2782

Issue

Section

ORIGINAL ARTICLE

Most read articles by the same author(s)