Granulosa cell tumors of the ovary: staging and treatment

Abstract

The purpose of this study was to analise the surgical and histoIogicaI resuIts which could help in the management for staging and treating patients with ovarian granulosa cell tumors. Eleven women with this type of tumor who were seen in the Center of Integral Assistance to Women's Health (University of Campinas - State of São Paulo) from January 1990 to Dezember 1994 were analised. Follow-up was done until August 1996. The mean age was 46 (18-67). Two patients underwent a bilateral salpingooforecromy with hysterectom) apendicectomy and omentectomy, and in seven the surgical procedure included also a pelvic and paraortic retroperitonial lymphadenectomy. Two patients had unressected intrabdominal disease. Concluding the surgical and histological analysis, five women had stage IJIC disease; one, stage IC, and five, stage IA. The histological review showed 10 adult-type neoplasm and juvenile-type one. In all cases there were diagnosed two or more histological granulosa cell tumor patterns, predominantely the solid type (7/11). Adjuvant cheinotherapy - six cycles of carboplatin (300 mg/m²) and ciclophosphamide (500 mg/ m²) - was done in al patients in stage IC or IIIC. At the last follow-up, 20 to 71 months after; all patients with localized, tumors were disease-free. On the other hand, three out five women with advanced cancer had persistent tumors in spite of adjuvant treatment.