Carcinoma Avançado do Colo do Útero: Tratamento Inicial pela Quimioterapia

Authors

  • Jurandyr Moreira de Andrade Departamento de Ginecologia e Obstetrícia - Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto. Universidade de São Paulo (USP). São Paulo (SP), Brasil
  • Heitor Ricardo Cosiski Marana Departamento de Ginecologia e Obstetrícia - Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto. Universidade de São Paulo (USP). São Paulo (SP), Brasil
  • Maria Angeles S. L. Velludo Departamento de Ginecologia e Obstetrícia - Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto. Universidade de São Paulo (USP). São Paulo (SP), Brasil
  • Sérgio Bighetti Departamento de Ginecologia e Obstetrícia - Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto. Universidade de São Paulo (USP). São Paulo (SP), Brasil

DOI:

https://doi.org/10.32635/2176-9745.RBC.1994v40n4.3000

Keywords:

Quimioterapia e Carcinoma do Colo do Útero, Carcinoma do Colo do Útero, Carcinoma Avançado do Colo do Útero, Tratamento Neoadjuvante

Abstract

A new approach to the treatment of advanced cervical carcinoma was utilized in order to make patients operable. Forty patients in stages lla, llb and II Ib ofthe disease were initially treated with chemotherapy (cisplatinum 80-100/m2/cycle and bleomycin 15 mg/cycle) followed by radiotherapy. After combined treatment, 21 patients could be operated upon (12 Wertheim Meigs and nine pan-hysterectomies), without further complications. 85.7% of the operated tumors were exophytic, andonly 19.3% endophiticus. No residual tumors were foundin eight patients (21.7%> ofthe cases). Samples obtained by pelvic lymphadenectomy revealed a low percentage of nodular metastasis (16.7%). Two patients who died and one who had a recurrence on the vaginal fornix were from the endophytic group. We conclude that combined chemotherapy and radiotherapy were effective in rendering more than half the patients susceptible to surgery. Exophytic tumors had the best prognosis in terms of clinical response and disease-free survival. Chemotherapy probably reduced the percentage of pelvic node metastasis.

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References

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Published

2023-06-05

How to Cite

1.
Andrade JM de, Marana HRC, Velludo MASL, Bighetti S. Carcinoma Avançado do Colo do Útero: Tratamento Inicial pela Quimioterapia. Rev. Bras. Cancerol. [Internet]. 2023 Jun. 5 [cited 2024 Nov. 25];40(4):191-5. Available from: https://rbc.inca.gov.br/index.php/revista/article/view/3000

Issue

Vol. 40 No. 4 (1994): Oct./Nov./Dec.

Section

ORIGINAL ARTICLE

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