Incidence, Mortality and Survival of Pediatric Cancer in Uruguay 2011-2015

Authors

  • Fabiana Morosini Centro Hospitalario Pereira Rossell, Departamento de Oncología y Hematología. Montevideo, Uruguay. https://orcid.org/0000-0002-3864-8967
  • Anaulina Silveira Centro Hospitalario Pereira Rossell, Departamento de Oncología y Hematología. Montevideo, Uruguay. https://orcid.org/0000-0003-3296-363X
  • Vanessa Arias Centro Hospitalario Pereira Rossell, Departamento de Oncología y Hematología. Montevideo, Uruguay. https://orcid.org/0000-0003-1527-7988
  • Luis Castillo Centro Hospitalario Pereira Rossell, Departamento de Oncología y Hematología. Montevideo, Uruguay. https://orcid.org/0000-0003-2880-0838

DOI:

https://doi.org/10.32635/2176-9745.RBC.2023v69n1.3054

Keywords:

neoplasms, infant mortality, survival rate, child, Uruguay

Abstract

Introduction: Childhood cancer is a small proportion of all cancers but is still a major public health problem. Objective: To describe the 5-year incidence and mortality rates and net survival of childhood cancer in Uruguay. Method: Data on all malignant tumors diagnosed in children aged 0-14 were included for the period 2011-2015, obtained from the National Pediatric Registry of Cancer and from the Ministry of Health Mortality Registry, classified according to the International Classification of Childhood Cancer (ICCC-3). Information on the total population was obtained from national census records. Follow up was made until December 2020. Results: The standardized incidence rate was 128/million children per year. The distribution of the disease was similar to developed countries. The overall mortality rate was 28.2/million, with a net overall survival of 79.6% for the total population. Conclusion: Childhood cancer incidence in Uruguay is similar to developed countries. Progress in diagnosis and care have improved survival immensely, but efforts must continue to keep this trend and ameliorate the outcomes.

Downloads

Download data is not yet available.

References

Howlader N, Noone AM, Krapcho M, et al., editors. SEER cancer statistics review, 1975-2018 [Internet]. Bethesda (MD): National Cancer Institute; 2021 [cited 2021 Aug 15]. Available from: https://seer.cancer.gov/csr/1975_2018

World Health Organization [Internet]. Geneva: WHO; c2023. Childhood cancer; 2021 Dec 13 [cited 2021 Aug 15]. Available from: https://www.who.int/news-room/fact-sheets/detail/cancer-in-children

Pan American Health Organization [Internet]. Washington (DC): PAHO; [date unknown]. Childhood and adolescence cancer; [cited 2021 Aug 15]. Available from: https://www.paho.org/en/topics/childhood-and-adolescence-cancer

International Agency for Research on Cancer; World Health Organization. Global initiative for cancer registry development [Internet]. Lyon (France): IARC; c2022. [cited 2021 Aug 15]. Available from: https://gicr.iarc.fr

Jensen OM, Parkin DM, MacLennan R, editors. Cancer registration: principles and methods [Internet]. Lyon (France): IARC; 1991. (IARC Scientific Publication; nº 95) [cited 2021 Aug 15]. Available from: https://publications.iarc.fr/_publications/media/download/3509/5f5f43d160b02029dea997b05cce7b7d41c50702.pdf

National Cancer Institute [Internet]. [Bethesda (MD)]: National Cancer Institute (US); [date unknown]. Cancer in children and adolescents; [reviewed 2021 Nov 4; cited 2021 Aug 15]. Available from: https://www.cancer.gov/types/childhood-cancers/child-adolescent-cancers-fact-sheet

Lam CG, Howard SC, Bouffet E, et al. Science and health for all children with cancer. Science. 2019;363(6432):1182-6. doi: https://doi.org/10.1126/science.aaw4892 DOI: https://doi.org/10.1126/science.aaw4892

Stiller CA. Epidemiology and genetics of childhood cancer. Oncogene. 2004;23(38):6429-44. doi: https://doi.org/10.1038/sj.onc.1207717 DOI: https://doi.org/10.1038/sj.onc.1207717

Steliarova-Foucher E, Colombet M, Ries LAG, et al. International incidence of childhood cancer, 2001-10: a population-based registry study. Lancet Oncol. 2017;18(6):719-31. doi: https://doi.org/10.1016/S1470-2045(17)30186-9 DOI: https://doi.org/10.1016/S1470-2045(17)30186-9

Castillo L, Fluchel M, Dabezies A, et al. Childhood cancer in Uruguay: 1992-1994. Incidence and mortality. Med Pediatr Oncol. 2001;37(4):400-4. doi: https://doi.org/10.1002/mpo.1217 DOI: https://doi.org/10.1002/mpo.1217

Castillo Malmiera L, Dabezies Antia A, Dufort y Álvarez G, et al. Evolución del cáncer pediátrico en Uruguay (1992-2011). Arch Pediatr Urug. 2012;83(1):26-30.

Comisión Honoraria de Lucha contra el Cáncer [Internet]. Montevideo: CHLCC; [1989]. Registro Nacional de Cáncer; [acceso 2022 jul 1]. Disponible en: https://www.comisioncancer.org.uy/categoria/Registro-Nacional-de-Cancer-14

Ministerio de Salud (UY) [Internet]. Montevideo (Uruguay): Ministerio de Salud; c2020. Estadísticas de defunciones; [acceso 2022 jul 1]. Disponible en: https://uins.msp.gub.uy/index.html#def

Instituto Nacional de Estadística. Resultados del Censo de población 2011: población, crecimiento y estructura por sexo y edad [Internet]. Uruguay: INE; [2012] [acceso 2022 jul 1]. Disponible en: https://www.ine.gub.uy/documents/10181/35289/analisispais.pdf

Steliarova-Foucher E, Stiller C, Lacour B, et al. International classification of childhood cancer, third edition. Cancer. 2005;103(7):1457-67. doi: https://doi.org/10.1002/cncr.20910 DOI: https://doi.org/10.1002/cncr.20910

Fritz A, Percy C, Jack A, et al., editors. ICD-O: International classification of diseases for oncology [Internet]. 3rd ed. Geneva: WHO; 2020 [cited 2022 July 1]. Available from: https://apps.who.int/iris/bitstream/handle/10665/96612/9789241548496_eng.pdf

Ahmad OB, Boschi-Pinto C, Lopez AD, et al. Age standardization of rates: a new WHO standard [Internet]. Geneva: World Health Organization; 2001. (GPE Discussion Paper Series; nº 31) [cited 2022 July 1]. Available from: https://cdn.who.int/media/docs/default-source/gho-documents/global-health-estimates/gpe_discussion_paper_series_paper31_2001_age_standardization_rates.pdf

Cho H, Howlader N, Mariotto AB, et al. Estimating relative survival for cancer patients from the SEER Program using expected rates based on Ederer I versus Ederer II method. [Bethesda (MD)]: National Cancer Institute (US); 2011. (Technical Report #2011-01). Available from: https://surveillance.cancer.gov/reports/

Stata statistical software: release 16. College Station (Texas): StataCorp LLC; 2019.

ACCIS: Automated Cancer Information System [Internet]. Lyon (France): IARC. c1965-2023 [cited 2021 Aug 15]. Available from: https://accis.iarc.fr

Chatenoud L, Bertuccio P, Bosetti C, et al. Childhood cancer mortality in America, Asia, and Oceania, 1970 through 2007. Cancer. 2010;116(21):5063-74. doi: https://doi.org/10.1002/cncr.25406 DOI: https://doi.org/10.1002/cncr.25406

Prieto Bravo C, Cuadrado C, Gónzales I. Cáncer Infantil en latinoamérica: un análisis comparativo de la respuesta de los sistemas de salud. Medwave [Internet]. 2019;19(Suppl 1):SP95. doi: http://doi.org/10.5867/medwave.2019.S1 DOI: https://doi.org/10.5867/medwave.2019.S1

Downloads

Published

2023-02-08

How to Cite

1.
Morosini F, Silveira A, Arias V, Castillo L. Incidence, Mortality and Survival of Pediatric Cancer in Uruguay 2011-2015. Rev. Bras. Cancerol. [Internet]. 2023 Feb. 8 [cited 2024 Jul. 22];69(1):e-163054. Available from: https://rbc.inca.gov.br/index.php/revista/article/view/3054

Issue

Section

ORIGINAL ARTICLE

Most read articles by the same author(s)