Aspectos dos quadros clínico, citológico e da microbiota fúngica da mucosa bucal de pacientes com carcinoma da boca, antes e durante a radioterapia
DOI:
https://doi.org/10.32635/2176-9745.RBC.1990v36n1/4.3116Keywords:
Oral Cancer, Oral Cytology, Gram Smears, Fungi, C. AlbicansAbstract
The authors studied clinically lesions of the oral mucosa as well as control areas in patients with oral cancer, before and during radiotherapy, utilizing exfoliative cytology (Papanicolaou and PAS) and smears stained by Gram. A significative increase of yeasts during treatment was observed with predominance of filamentous forms as well as cytologic alterations. Clinically, well defined areas of candidosis of atrophic or pseudomembranous type were observed beside areas of mucositis. A great majority of the alterations were represented by white and red lesions, difficulting a clinical dia gnosis. Symptomatology was negative before treatment and during treatment patients revealed a high number of complaints including burning sensation, xerostomy and loss of taste among other symptoms.
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References
BODEY GP. Candidiasis in cancer patients. Proceedings of a Symposium: Candidiasis. A growing concern. Amer J Med 1984; 77: 9-13.
BODEY GP. Infection in patients with cancer. In: HolIandJF& Frei E. Cancer Medicine. Philadelphia: Lea& Febiger 1982: 1339-72.
BOGGS DR, WILLIAMS AF, HOWELL JR. A. Thrush in malignant neoplasticdisease. Arch Inter Med 1961; 107: 354-60. DOI: https://doi.org/10.1001/archinte.1961.03620030042005
BORAK S, BIRMAN EG. Alterações da mucosa normal em pacientes portadores de carcinoma epidermóide submetidos a tratamento radioterápico. Estudo clínico e citológico. Rev Bras Cirurg Cab Pesc 1984; 8: 71-83.
BROWN LA, DREIZEN S, HANDLER S, JOHNSTON DA. Effect of radiation-induced xerostomia on human oral microflora. J Dent Res 1975; 54: 740-50. DOI: https://doi.org/10.1177/00220345750540040801
CHEN TY, WEBSTER JH. Oral monilia study on patients with head and neck cancer during radiotherapy. cancer 1974; 34: 246-9. DOI: https://doi.org/10.1002/1097-0142(197408)34:2<246::AID-CNCR2820340203>3.0.CO;2-J
BREIZEN S. Oral Candidiasis. Proceedings of a Symposium: Candidiasis. A growing concern. Amer J Med 1984; 77: 28-33.
FLETCHER GH, MACCOMB WS. Radiation therapy in the management of cancers of the oral cavity and oropharynx. Springfield, Thomas 1962: 3-12.
HART PD, RUSSEL Jr. EL, REMINGTON JS. The compromised host and infection II - Deep tungal infection. J lnfect Dis 1969; 120: 169-91. DOI: https://doi.org/10.1093/infdis/120.2.169
HOANSTEIN OP, GRÂBEL A, SCHIRNER E. Prevalence rates of candidosis in leukoplakias and carcinomas of the oral cavity. Arch Derm Res 1979; 266: 99-102. DOI: https://doi.org/10.1007/BF00412869
HURLEY A, WINNER H. The pathogenicity of Candida tropic.alls. J Path Bact 1962; 84: 33-8. DOI: https://doi.org/10.1002/path.1700840104
KING ER, ELZAY RP, DETTMAN PM. Effects of ionizing radiation in the human oral cavity and oropharynx: results of a survey. Radiology 1980; 91: 1001-7. DOI: https://doi.org/10.1148/91.5.1001
KOLNICK JR. Oral candidosis - Report of a case implicating Candida parapsilosis as a pathogen. Oral Surg 1980; 50: 411-5. DOI: https://doi.org/10.1016/S0030-4220(80)80007-7
MARTIN MV, AL-TlKRlTl V, BRAMLEY PA. Yeasts of the mouth and skin during and after irradiation for oral and laryngeal cancer. AmerJ Microbiol 1981; 14: 457-67. DOI: https://doi.org/10.1099/00222615-14-4-457
MONTGOMERY PW. A study of exfoliative cytology of normal human oral mucosa. J Dent Res 1951; 30: 1-8. DOI: https://doi.org/10.1177/00220345510300010501
RIPPON M. Medical Mycology. Philadelphia: Saunders 1982: 484-531.
ROBU B, GRIFFIN IL, GROCKERMAN JP. Oral candidiasis in cancer patients. Sth Med (Bgham, Ala) 1984; 77: 312-4. DOI: https://doi.org/10.1097/00007611-198403000-00011
ROSENTHAL LE, BERNARD W. The effects of radiotherapy on oral tissue. J Prosth Dent 1965; 15: 153-6. DOI: https://doi.org/10.1016/0022-3913(65)90075-2
RUBIN RL, DOKU HC. Therapeutic radiology - The modalities and their effects on oral tissues. J Amer Dent Ass 1976; 92: 732-9. DOI: https://doi.org/10.14219/jada.archive.1976.0449
SHEDD DP. Cancer of the head neck. In: Hoíland JE & Frei III, E. Cancer medicine. Philadelphia: Lea & Febiger 1982: 1671-85.
SHEPHERD MG. Candidiasis: and infectious disease eI increasing importance. N Z DentJ 1982: 78: 89-93.
SILVERMAN JR. S, CHIERICI G. Radiation therapy of oral carcinoma. I - Eftects on oral tissue and management of the periodontium. J Periodont 1965; 36: 478-84. DOI: https://doi.org/10.1902/jop.1965.36.6.478
SILVERMAN JR. S, LUANGJARMEKORN L, GREENSPAN D. Occurrence eI oral Candida in irradiated head and neck cancer patients. J Oral Med 1984; 39: 194-5.
TASCHDJIAN CL, KOZINN PJ, TONI EF. Laboratory and clinical studies on candidiasis in newborn inlants. J Pediat 1957; 50: 425-33. DOI: https://doi.org/10.1016/S0022-3476(57)80252-2
TASCHDJIAN CL, KOZINN PJ, TONI EF. Opportunistic yeasts infections, with special reference to candidiasis. Ann NY Acad Sci 1970; 174: 606-22. DOI: https://doi.org/10.1111/j.1749-6632.1970.tb45586.x
