Aspectos dos quadros clínico, citológico e da microbiota fúngica da mucosa bucal de pacientes com carcinoma da boca, antes e durante a radioterapia
DOI:
https://doi.org/10.32635/2176-9745.RBC.1990v36n1/4.3116Palabras clave:
Câncer Bucal, Leveduras, Radiomucosite, Citologia Esfolfativa, C. AlbicansResumen
Os autores estudaram clinicamente as lesões e alterações observadas na mucosa bucal de pacientes com carcinoma da boca, independente da neoplasia presente, antes e durante o tratamento radioterápico, por meio da citologia esfoliativa (Papanicolaou e PAS) e esfregaços corados pelo Gram. Comprovou-se um aumento de leveduras durante o tratamento, predominando as formas filamentosas, consideradas mais patogênicas. Podem-se detectar áreas bem definidas de candidose, quer do tipo atrófica ou pseudomembranosa, além de áreas de radiomucosite, embora a associação de lesões brancas e eritematosas predominassem levando a um mascaramento do quadro clínico presente. Aumento significativo de sintomas desde ardor a xerostomia, entre outros, foi observado durante o tratamento.
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BODEY GP. Candidiasis in cancer patients. Proceedings of a Symposium: Candidiasis. A growing concern. Amer J Med 1984; 77: 9-13.
BODEY GP. Infection in patients with cancer. In: HolIandJF& Frei E. Cancer Medicine. Philadelphia: Lea& Febiger 1982: 1339-72.
BOGGS DR, WILLIAMS AF, HOWELL JR. A. Thrush in malignant neoplasticdisease. Arch Inter Med 1961; 107: 354-60. DOI: https://doi.org/10.1001/archinte.1961.03620030042005
BORAK S, BIRMAN EG. Alterações da mucosa normal em pacientes portadores de carcinoma epidermóide submetidos a tratamento radioterápico. Estudo clínico e citológico. Rev Bras Cirurg Cab Pesc 1984; 8: 71-83.
BROWN LA, DREIZEN S, HANDLER S, JOHNSTON DA. Effect of radiation-induced xerostomia on human oral microflora. J Dent Res 1975; 54: 740-50. DOI: https://doi.org/10.1177/00220345750540040801
CHEN TY, WEBSTER JH. Oral monilia study on patients with head and neck cancer during radiotherapy. cancer 1974; 34: 246-9. DOI: https://doi.org/10.1002/1097-0142(197408)34:2<246::AID-CNCR2820340203>3.0.CO;2-J
BREIZEN S. Oral Candidiasis. Proceedings of a Symposium: Candidiasis. A growing concern. Amer J Med 1984; 77: 28-33.
FLETCHER GH, MACCOMB WS. Radiation therapy in the management of cancers of the oral cavity and oropharynx. Springfield, Thomas 1962: 3-12.
HART PD, RUSSEL Jr. EL, REMINGTON JS. The compromised host and infection II - Deep tungal infection. J lnfect Dis 1969; 120: 169-91. DOI: https://doi.org/10.1093/infdis/120.2.169
HOANSTEIN OP, GRÂBEL A, SCHIRNER E. Prevalence rates of candidosis in leukoplakias and carcinomas of the oral cavity. Arch Derm Res 1979; 266: 99-102. DOI: https://doi.org/10.1007/BF00412869
HURLEY A, WINNER H. The pathogenicity of Candida tropic.alls. J Path Bact 1962; 84: 33-8. DOI: https://doi.org/10.1002/path.1700840104
KING ER, ELZAY RP, DETTMAN PM. Effects of ionizing radiation in the human oral cavity and oropharynx: results of a survey. Radiology 1980; 91: 1001-7. DOI: https://doi.org/10.1148/91.5.1001
KOLNICK JR. Oral candidosis - Report of a case implicating Candida parapsilosis as a pathogen. Oral Surg 1980; 50: 411-5. DOI: https://doi.org/10.1016/S0030-4220(80)80007-7
MARTIN MV, AL-TlKRlTl V, BRAMLEY PA. Yeasts of the mouth and skin during and after irradiation for oral and laryngeal cancer. AmerJ Microbiol 1981; 14: 457-67. DOI: https://doi.org/10.1099/00222615-14-4-457
MONTGOMERY PW. A study of exfoliative cytology of normal human oral mucosa. J Dent Res 1951; 30: 1-8. DOI: https://doi.org/10.1177/00220345510300010501
RIPPON M. Medical Mycology. Philadelphia: Saunders 1982: 484-531.
ROBU B, GRIFFIN IL, GROCKERMAN JP. Oral candidiasis in cancer patients. Sth Med (Bgham, Ala) 1984; 77: 312-4. DOI: https://doi.org/10.1097/00007611-198403000-00011
ROSENTHAL LE, BERNARD W. The effects of radiotherapy on oral tissue. J Prosth Dent 1965; 15: 153-6. DOI: https://doi.org/10.1016/0022-3913(65)90075-2
RUBIN RL, DOKU HC. Therapeutic radiology - The modalities and their effects on oral tissues. J Amer Dent Ass 1976; 92: 732-9. DOI: https://doi.org/10.14219/jada.archive.1976.0449
SHEDD DP. Cancer of the head neck. In: Hoíland JE & Frei III, E. Cancer medicine. Philadelphia: Lea & Febiger 1982: 1671-85.
SHEPHERD MG. Candidiasis: and infectious disease eI increasing importance. N Z DentJ 1982: 78: 89-93.
SILVERMAN JR. S, CHIERICI G. Radiation therapy of oral carcinoma. I - Eftects on oral tissue and management of the periodontium. J Periodont 1965; 36: 478-84. DOI: https://doi.org/10.1902/jop.1965.36.6.478
SILVERMAN JR. S, LUANGJARMEKORN L, GREENSPAN D. Occurrence eI oral Candida in irradiated head and neck cancer patients. J Oral Med 1984; 39: 194-5.
TASCHDJIAN CL, KOZINN PJ, TONI EF. Laboratory and clinical studies on candidiasis in newborn inlants. J Pediat 1957; 50: 425-33. DOI: https://doi.org/10.1016/S0022-3476(57)80252-2
TASCHDJIAN CL, KOZINN PJ, TONI EF. Opportunistic yeasts infections, with special reference to candidiasis. Ann NY Acad Sci 1970; 174: 606-22. DOI: https://doi.org/10.1111/j.1749-6632.1970.tb45586.x
