Tumores Germinativos Avançados - Tratamento com PVB
DOI:
https://doi.org/10.32635/2176-9745.RBC.1987v33n2.3200Keywords:
Germ-Cell Tumors, ChemotherapyAbstract
Thirteen patients with advanced germ-cell tumors were treated with PVB chemotherapy at Hospital de Oncologia - INA MPS - Rio de Janeiro, Brazil, during the last three years. One of these patients was not suitable for evaluation. In eight patients there was complete (66.7%) and in four partial remission (33.3%); in two cases relapses ocurred 12 and is 16 months after chemotherapy Three patients died afterpartial remission, two af ter failure of second choice therapeutic scheme (VP16 + CDDP), and one for discontinuing second choice scheme. Only one patient underwent two chemotherapy cicles. Mean follow-up was 21 months. The scheme was considered to be effectual and well tolerated. Remission indexes must be re-evaluated after longer periods of time.
Downloads
References
Hainswortb JD, Greco FA - Testicular Gerrrr-cefl Neoplasms. The American Journal of Medicirre, 1983, 75; 817-832. DOI: https://doi.org/10.1016/0002-9343(83)90413-8
Logothetis CJ et al. - chemotherapy of Extragonadai Germ-CeH Tumors. —J Ciin. Oncol 1985; 3, 316-325 DOI: https://doi.org/10.1200/JCO.1985.3.3.316
Einhorn LH - combination chemotherapy with Cis-diciorodiammineplatinum in disserriinated testicular cancer. Cancer Treat. Rep. 1979; 63 1659-1662
Stanton GF, Bosi GJ, Whitmore WF, Herr HJr, Sogani P, Morse M, Golbey RB - VAB-6 as initial treatment of patients with advanced seminoma J. Chn Oncology 1985, 3. 336339 DOI: https://doi.org/10.1200/JCO.1985.3.3.336
Vugrin D, Wiritmore FJr, Golver RB - vinbiastine, Actinomycin D, Bieomycin, ciclophosphamide and cis-platinum combination chemotherapy in metastatic testis cancer A 1 year program. The Journal of uroiogy 1982, 128 1205-1208. DOI: https://doi.org/10.1016/S0022-5347(17)53426-6
Einhorn LH - Chemotherapy of Testicular Cancer. Mediguide to Oncology 1982, ,2 issue 1. DOI: https://doi.org/10.1007/978-1-4471-1332-4_10
Montie JE - changing concep:s in lhe management of testis cancer, Cleveland clinic quarterly 1984; 51. 381-385. DOI: https://doi.org/10.3949/ccjm.51.2.381
Donohue JP, Rowland RG - The role of surgery lo advanced testicular cancer. Cancer 1984; 54 2716-2721. DOI: https://doi.org/10.1002/1097-0142(19841201)54:2+<2716::AID-CNCR2820541418>3.0.CO;2-H
Brenner J, Vugrin D, Whitmore WF - cytoreductive Surgery for Advanced Non-seminomatous Germ-cell Tumors of Testis Urology 1982, XiX: 6. DOI: https://doi.org/10.1016/0090-4295(82)90001-2
Logothetis CJ, Samuels ML, Trindade A, Davelas J - The Growing Teratorna Syndrome. Cancer 1982, 50: 1629-1635. DOI: https://doi.org/10.1002/1097-0142(19821015)50:8<1629::AID-CNCR2820500828>3.0.CO;2-1
Chong C, Logothetis CJ, Escbenbach AV, Ayala A, Sawveis M – Orchiectomy o advanced Germ-Cell Cancer Following intensive Chemotherapy: A companson of systemic to testicular response. The Journal of Urology 1986, 136. 1221-1223 DOI: https://doi.org/10.1016/S0022-5347(17)45290-6
Ozols RF, Gorden BJ, Wesley JJM M, Ostchega Y, Young RC - High-dose Cisplatinum in hipertonic Sahne Annals of internal Medicine 1984, 100, 19-24 DOI: https://doi.org/10.7326/0003-4819-100-1-19
Von der Maase H et al - The other testicle Bril. Med J. 1986, 293' 1398-1401 clinicai Oncology Alert 1987, 2 2 DOI: https://doi.org/10.1136/bmj.293.6559.1398
Loeher PJ, Williams SB, Ciark SA - Pr. Am. Soc Clin Oncol 1983,2 139
Golbey RB, Reynonds T vugrin O - chemotherapy of metastatic germ-cell tumors. Seminars in oncology 1979; 6: 1
Einhorn LH, Willians SD, Mandelbaun I, Donohue JP - Surgical Ressection in disseminated testicular cancer following Chemotherapeutic Cytoreduction Cancer 1981, 48. 904 908. DOI: https://doi.org/10.1002/1097-0142(19810815)48:4<904::AID-CNCR2820480407>3.0.CO;2-O
Vugrin D, Whithmore WF, Sogami PC, Bains M, Herr HW, Golbey RB - Combined Chemotherapy and Surgery in treatment of advanced germ-cell tumors. Cancer 1981, 47: 2228-2231. DOI: https://doi.org/10.1002/1097-0142(19810501)47:9<2228::AID-CNCR2820470920>3.0.CO;2-D
Boble A, Studer E, Sonntag 6W, Scherdegger JR - Primary or Secondary extragonadal germ-cell tumors The .Journal of Urology 1986; 135. 939942. DOI: https://doi.org/10.1016/S0022-5347(17)45930-1
Gelderman WAH, Koops HS, Sleilfer D, Oosterhuis JW, Hoff JO - Treatment of retroperitoneal residual tumor after PVB chemotherapy of nonseminomatous testicular tumors. Cancer 1986; 58. 1418-1421 DOI: https://doi.org/10.1002/1097-0142(19861001)58:7<1418::AID-CNCR2820580706>3.0.CO;2-T
Wettlaufer JM, Feiner AS, Robinson WA - vincristine, Cisplatin and Bleomycin with surgery in the management of advanced metastatic nonseminomatous testis tumors. Cancer 1984; 53: 203-209 DOI: https://doi.org/10.1002/1097-0142(19840115)53:2<203::AID-CNCR2820530203>3.0.CO;2-U
