Fatores Prognósticos no Carcinoma do Colo de Útero, Estádio III
DOI:
https://doi.org/10.32635/2176-9745.RBC.1986v32n1.3230Keywords:
Cancer of the Cervix, Parametrial Infiltration, Anemia, Prognostic FactorAbstract
A total of 148 patients with carcinoma of the cervix, stage III, referred to the Radiotherapy Department of the Instituto Nacional de Câncer, from January 1975 to December 1979 were evaluated in order to try to establish possible prognostic factors. The extent of parametrial infiltration was found to be the most importante factor, patients with unilateral infiltration presenting a statistically superior survival rate over those with bilateral disease (p<0,005). Anemia was also of prognostic value and the hemoglobin level must be kept above 12gm. Although patients over 50 year of age did have a better survival rate, the difference did not reach statistical significance. The extent of parametrial infiltration seems to be the most important prognostic factor and should be kept in mind when designing new studies.
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References
Brumini R. Câncer no Brasil — dados histológicos 1976 — 1980 Campanha Nacional de Combate ao Câncer. Ministério da Saúde, 1982.
Parkin DM, Stjernsward J, Mu ir CS. Estimates of worldwide frequency of 12 major cancer. Bulletin of WH0. 1984; 62(2).
Vera R. Reflections on the management of cancer of the cervix in developing countries. Int J Radiat Oncol Biol Phys 1982; 8: 953-955. DOI: https://doi.org/10.1016/0360-3016(82)90109-2
Souhami L, Melo JAC, Pareja GV. The treatment of stage III carcinoma of uterine cervix with telecobalt irradiation. Gynec Oncol (no prelo).
Fletcher GH. Cancer of the uterine cervix, Janeway lecture - 1970. Am J Roentgenol 1971; 111: 225-242. DOI: https://doi.org/10.2214/ajr.111.2.224
Marcial VA. Carcinoma of the cervix. Present status and future. Câncer 1977; 39: 945-958. DOI: https://doi.org/10.1002/1097-0142(197702)39:2+<945::AID-CNCR2820390734>3.0.CO;2-U
Montana GS, Fowler WC, Varia MA, Walton LA, Marck Y, Shemanski L. Carcinoma of the cervix, stage III. Results of radiation therapy. Cancer 1986; 57: 148-154. DOI: https://doi.org/10.1002/1097-0142(19860101)57:1<148::AID-CNCR2820570130>3.0.CO;2-7
Isaacs JH. Variations in response to therapy for cervical câncer. Am J obstet Gynecol 1971; 110: 390. DOI: https://doi.org/10.1016/0002-9378(71)90735-6
Bush RS. In: Malignancies of the Ovary, Uterusand Cervix. Edward Arnold, London. 1979: 171.
Bush RS, Jenkin RDT, Allt WEC, et al. Definitive evidence for hypoxic cells influencing cure in cancer therapy. Br J Cancer (Supp) 1978; 37: 302-306. DOI: https://doi.org/10.1038/bjc.1978.96
Benstead K, Cowic VJ, Blair V, Hunter RD. Stage III carcinoma of cervix. The importance of increasing age and extent of parametrial infiltration. Radiot Oncol 1986; 5: 271-276. DOI: https://doi.org/10.1016/S0167-8140(86)80175-X
Prempree T, Patanaphan V, Viravathana T, et al. Radiation treatment of carcinoma of the cervix with extension into the endometrium: a reappraisal of its significance. Cancer 1982; 49: 2015-2020. DOI: https://doi.org/10.1002/1097-0142(19820515)49:10<2015::AID-CNCR2820491012>3.0.CO;2-3
Jenkin RDT, Stryken JA. The influence of blood pressure on survival in cancer of the cervix. Br J Radiol 1968; 41: 913-920. DOI: https://doi.org/10.1259/0007-1285-41-492-913
Dische S, Bennett MH, Saunders Ml, Anderson P. Tumour regression as a guide to prognosis: a clinical study. Br J Radiol 1979; 53: 454-461. DOI: https://doi.org/10.1259/0007-1285-53-629-454
Kaplan EL, Meier P. Non parametric estimation for incomplete obsentations. J Am Stat Assoe 1958; 53: 457-481. DOI: https://doi.org/10.1080/01621459.1958.10501452
Aristizabal SA, Valencia A, Ocampo G, Surwit E. Interstitial parametrial irradiation in cancer of the cervix stage II B-lll B. Endocurie Hypertherm Oncol 1985; 1: 41-48.
Prempree T. Parametrial implant in stage III B cancer of the cervix. III. Afive-year study. Câncer 1983; 52: 748-750. DOI: https://doi.org/10.1002/1097-0142(19830815)52:4<748::AID-CNCR2820520431>3.0.CO;2-O
Evans JC, Bergsjo P. Influence of anemia on the results of radiotherapy in carcinoma of the cervix. Radiol 1965; 84: 709-716. DOI: https://doi.org/10.1148/84.4.709
Hierlihy P, Jenkin RDT, Stryker JA. Anemia as a prognostic factor in cancer of the cervix. Can Med Assoe J 1969; 100: 1100-1102.
Thomson JM, Spratt JS. Tratment policies affecting survival in patients with carcinoma of the cervix. Radiol 1979; 127: 771-774. DOI: https://doi.org/10.1148/127.3.771
Kapp DS, Fischer D, Gutierrez E, Kohorn El, Schwartz PE. Pre treatment prognostic factors in carcinoma of the uterine cervix: a multivariate analysis of the effect of age, stage, histology and blood counts on survival. Int J Radiat Oncol Biol Phys 1983; 9: 445-455. DOI: https://doi.org/10.1016/0360-3016(83)90060-3
