Quimioterapia Adjuvante no Câncer da Mama
DOI:
https://doi.org/10.32635/2176-9745.RBC.1985v31n2.3320Keywords:
Breast Cancer, Adjuvant ChemotherapyAbstract
A retrospectiva analysis of adjuvant chemotherapy in 95 patients with breast cancer was carried out. Patient stratification was made according to pathological status of axilary lymphonodes: group A patients with 1-3 positive nodes and group B patients with more than 3 positive lymphnodes. At sixty months the probability of survival was 86.1% for group A and 83% for group B (p=0.042) and, probability of disease free survival was 86.1%> in group A and 64.4% in group B (p<0.001). Forty nine patients were foilowed for at least 2 years and analysis after 24 months showed survival of 95.4% for group A and 85,1% for B (p=0.014) and, survival free of disease of 86.3% in group A and 66,6% in group B (p =0.415). Recurrence rate was 23.4% for patients receiving 85%> or more of programmed dose and 45% for patients whith lower doses. Local recurrences were identical for patients with or without radiotherapy. A comparison with the Milan study was made.
Downloads
References
Adjuvant Chemotherapy of breast cancer. Summary of na NIH consensus statement. Bri Med J 281: 724-725, 1980. DOI: https://doi.org/10.1136/bmj.281.6242.724
Ahmann, D.: Status of adjuvant chemotherapy in patients with breast cancer. Cancer, 53: 724-728, 1984. DOI: https://doi.org/10.1002/1097-0142(19840201)53:3+<724::AID-CNCR2820531321>3.0.CO;2-8
Bedwinek, J.: Adjuvant irradiation for early breast cancer. Cancer, 53: 729-739, 1984. DOI: https://doi.org/10.1002/1097-0142(19840201)53:3+<729::AID-CNCR2820531322>3.0.CO;2-R
Bonadonna, G. et al.: Combination Chemotherapy as an adjuvante treatment in operable breast cancer. N EngI J Med, 294: 405-410, 1976. DOI: https://doi.org/10.1056/NEJM197602192940801
Bonadonna, G. et al.: The CMF program for operable breast cancer with positive axiliary nodes. Cancer, 39: 2904-2915, 1977. DOI: https://doi.org/10.1002/1097-0142(197706)39:6<2904::AID-CNCR2820390677>3.0.CO;2-8
Bonadonna, G. et al.: Are surgical adjuvant trials altering the course of breast cancer? Seminars in Oncol vol. 5, n? 4: 450-464, 1978.
Bonadonna, G. et al.: Dose-response effect of adjuvant chemotherapy in breast cancer. N Engl J Med, 304: 10-15, 1981. DOI: https://doi.org/10.1056/NEJM198101013040103
Carpenter, J. et al.: Favorabie factors in the adjuvant therapy of breast cancer. Câncer, 50: 18-23, 1982. DOI: https://doi.org/10.1002/1097-0142(19820701)50:1<18::AID-CNCR2820500105>3.0.CO;2-J
Chu, A. et al.: Comparasion of adjuvant postoperative radiotherapy and multiple-drug chemotherapy (CMF—VP) in operable breast cancer patients with more than four positive axiliary lymphnodes. Cancer, 50: 212-218, 1982, DOI: https://doi.org/10.1002/1097-0142(19820715)50:2<212::AID-CNCR2820500208>3.0.CO;2-V
Cowan, K. et al.: Recent progress in breast cancer management. Arch Intern Med, 141: 1055-1059, 1981. DOI: https://doi.org/10.1001/archinte.141.8.1055
Fisher, B. et al.: L-phenylaianine mustard (L—PAM) in the management of primary breast cancer. Cancer, 39: 2883-2903, 1977. DOI: https://doi.org/10.1002/1097-0142(197706)39:6<2883::AID-CNCR2820390676>3.0.CO;2-9
Fisher, E. et al.: Pathologic findings from the National Surgical Adjuvant Project for Breast Cancers (Protocol n° 4). Cancer, 53: 712-723, 1984. DOI: https://doi.org/10.1002/1097-0142(19840201)53:3+<712::AID-CNCR2820531320>3.0.CO;2-I
Harris, J. et al.: The role of radiation therapy in the primary treatment of carcinoma of the breast. Seminars in Oncol vol. 5, n° 4: 403-416, 1978.
Harris, J. et al.: Primary radiation therapy for early breast cancer. Cancer, 52: 2547-2552, 1983. DOI: https://doi.org/10.1002/1097-0142(19830615)51:12+<2547::AID-CNCR2820511328>3.0.CO;2-#
Henderson, C.: Chemotherapy of breast cancer. Cancer, 51: 2553-2559, 1983. DOI: https://doi.org/10.1002/1097-0142(19830615)51:12+<2553::AID-CNCR2820511329>3.0.CO;2-7
Kinne, D.: Surgical management of primary breast cancer. Cancer, 51: 2540-2546, 1983. DOI: https://doi.org/10.1002/1097-0142(19830615)51:12+<2540::AID-CNCR2820511327>3.0.CO;2-N
Mouridsen, H. et al.: Adjuvant systemic therapy in breast cancer; a review. Eur J Cancer Clin Oncol, vol. 19, n° 12: 1753-1770, 1983. DOI: https://doi.org/10.1016/0277-5379(83)90164-5
Stenkvist, B. et al.: Predicting breast cancer recurrence. Cancer, 50: 2884-2893, 1982. DOI: https://doi.org/10.1002/1097-0142(19821215)50:12<2884::AID-CNCR2820501231>3.0.CO;2-K
Veronesi, U. et al.: Conservative treatment of breast cancer. Cancer, 39: 2822-2826, 1977. DOI: https://doi.org/10.1002/1097-0142(197706)39:6<2822::AID-CNCR2820390670>3.0.CO;2-#
Veronesi, U.: Value of limited surgery for breast cancer. Seminars in Oncol vol. 5, n° 4: 395-402, 1978.
