Componente Psíquica da Síndrome da Toxicidade Precoce Induzida pela Quimioterapia Antineoplásica
DOI:
https://doi.org/10.32635/2176-9745.RBC.1985v31n2.3328Keywords:
Antincophasic Chemotherapy, Psychiatric Aspects, Precocious Toxicity Syndrome, Antecipatory Náusea and Vomiting, AnxietyAbstract
Precocious toxicity syndrome (PTS) due to cancer chemotherapy (CT) is defined as the symptoms that started until 24 hours after parenteral CT, with a variable duration of few hours up to 3 or more days; each symptom varies with time and intensity according to each drug and each patient. There are 2 components of this PTS: the first is a toxic component (with a theoretical pathogenic model which involves prostaglandins and leucotríens), and other psychosocial, with a different pathogenesis; they are independent from each other in time but interrelated in other aspects. This psychic component is described here in the following aspects: antecipatory nausea and/or vomiting, psychic reactional States (anxiety and depression) and psychological aspects of anorexia of the PTS. The author demonstrates that there is a positive correlation between anxiety and PTS' intensity. He also concludes that knowledge of diagnosis, fears content and cooperation by the patient to CT do not interfere or is modified by neither PTS' intensity nor anxiety.
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References
AItmaier, E. M.; Ross, W. E. & Moore, K.: A pilot investigation of the psychologic functioning of patients with antecipatory vomiting. Cancer 49: 201-4, 1982, DOI: https://doi.org/10.1002/1097-0142(19820101)49:1<201::AID-CNCR2820490139>3.0.CO;2-X
Bernstein, I. L.: Learned taste aversions in children receiving chemotherapy. Science 200: 1302-3, 1978. DOI: https://doi.org/10.1126/science.663613
Bernstein, I. L.; Webster, M. M. & Bernstein, I. D.: Food aversions in children receiving chemotherapy for cancer. Cancer 50: 2961-3, 1982. DOI: https://doi.org/10.1002/1097-0142(19821215)50:12<2961::AID-CNCR2820501243>3.0.CO;2-L
Blumberg, B.; Flaherty, M. & Lewis, J. (Eds.): Coping with cancer. National Institute of Health Publication, n° 80-2080, Sept. 1980.
Bonadonna, G.; Brusamolimo, E.; Valagussa, P.; Rossi, A.; Brugnatelli, L.; Brambilia, C.; De Lena, M.; Tancini, G.; Bajetta, E.; Musumeci, R. & Veronesi, U.: Combination chemotherapy as an adjuvant treatment in operable breast cancer. N. Engl. J. Med, 294: 405-10, 1976. DOI: https://doi.org/10.1056/NEJM197602192940801
Brophy, J. J.: Desordens psiquiátricas. In: Krupp, M. A. & Chatton, M. J. eds: Diagnóstico e Tratamento. 3a. ed. trad., Atheneu, São Paulo, 1980. p. 744-801.
Delgado, G. L.: Síndrome da toxicidade precoce dos quimioterápicos antineoplásicos: sua profilaxia e proposta de um modelo patogênico. Tese de Mestrado PUC-SP. Sorocaba (SP), outubro de 1983 (Banco de Teses da PUC-SP).
Delgado, G. L.; Stefanuto, W. & Novo, N. F.: Síndrome da toxicidade precoce induzida pela quimioterapia antineoplásica: efeito terapêutico da metoclopramida e corticosteróide versus placebo, e proposta de um modelo patogênico. Acta Oncológica Brasileira, 3: 19-29, 1983.
Delgado, G. L.: Anti-prostaglandínicos na profilaxia da síndrome da toxicidade precoce por quimioterápicos antineoplásícos. Tese de Doutorado PUC-SP. Sorocaba (SP), agosto de 1984. (Banco de Teses da PUC-SP).
Editorial: A view of general aspects of patient care in Oncology. Cancer Therapy Update, 2: 1-3, 1981.
HolIand, J.: Psychological aspects of oncology. Med. Clin. Norlit. Am, 61: 737-48, 1982. DOI: https://doi.org/10.1016/S0025-7125(16)31293-7
Kutz, I.; Borysenko, J. Z.; Come, S. E. & Benson, H.: Paradoxical emetic response to antiemetic treatment in cancer patient. N. Engl. J. Med, 303: 1480, 1980. DOI: https://doi.org/10.1056/NEJM198012183032514
Levy, S. M.: Biobehavioral interventions in behavioral medicine. An OverView. Cancer (Suppl) 50: 1928-35, 1982. DOI: https://doi.org/10.1002/1097-0142(19821101)50:9+<1928::AID-CNCR2820501305>3.0.CO;2-O
Maguire, P.: Psychosocial aspects and rehabilitation. Clin. Oncol, 1: 833-52, 1982.
May, R.: O significado da ansiedade. Zahar Editores S/A, Rio de Janeiro, 1980.
Meyerowitz, B. E.; Sparks, F. C. & Spears, I. K.: Adjuvant chemotherapy for breast carcinoma. Psychosocial implications. Cancer, 43: 1613-8, 1979. DOI: https://doi.org/10.1002/1097-0142(197905)43:5<1613::AID-CNCR2820430508>3.0.CO;2-8
Morrow, G. R.; Arseneau, J. C.; Asbury, R. F.; Bennett, J. M. & Boros, L.: Antecipatory nausea and vomiting with chemotherapy. N. Engl. J. Med, 306: 431-2, 1982. DOI: https://doi.org/10.1056/NEJM198202183060721
Morrow, G. R. & Morrei, C.: Behavioral treatment for the antecipatory nausea and vomiting induced by cancer chemotherapy. N. Engl. J. Med, 307: 1476-80, 1982. DOI: https://doi.org/10.1056/NEJM198212093072402
Nerenz, D. R.; Leventhal, H. & Love, R. R.: Factors contributing to emotional distress during cancer chemotherapy. Cancer, 50: 1020-7, 1982. DOI: https://doi.org/10.1002/1097-0142(19820901)50:5<1020::AID-CNCR2820500534>3.0.CO;2-J
Nesse, R. M.; Carli, T.; Curtis, G. C. & Kleinman, P. D.: Pretreatment nausea in cancer chemotherapy: a conditioned response? Psychosom Med, 42: 33-6, 1980. DOI: https://doi.org/10.1097/00006842-198001000-00004
Petitjean, F.; Sechter, D. & Bitoun, G.: Ansiedade e psico-terapias. Nouv Press Med (ed. bras.) 1: 577-80, 1982.
Peck, A. & Boland, J.: Emotional reactions to radiation treatment. Cancer, 40: 180-4, 1977. DOI: https://doi.org/10.1002/1097-0142(197707)40:1<180::AID-CNCR2820400129>3.0.CO;2-5
Sallan, S. E. & Cronin, C. M.: Nausea and vomiting. In: DeVita, V. T. Jr., Hellman, S. & Rosenberg, S. A. eds.: Cancer. Principies and practice of Oncology. J. B. Lipincott Co., Philadelphia, 1982. p. 1704-7.
Schavelzon, J.: Conducción psicológica del paciente y familiares. In: Schaveizon, J., ed.: Cancer. Enfoque psicológico. Editorial Galerna, Buenos Aires, 1978. p. 77-83.
Seigel, L. G. & Longo, D. L.: The control of chemotherapy induced emesis. Ann Intern Med, 95: 352-9, 1981. DOI: https://doi.org/10.7326/0003-4819-95-3-352
Senn, H. J.: General patient care. BulI Cancer, 19: 15-6, 1981,
Weddington, W. I/V. Jr.; Miller, N. J. & Sweet, D. L.: Antecipatory nausea and vomiting associated with cancer chemotherapy. N Engl J Med, 307: 825-6, 1982. DOI: https://doi.org/10.1056/NEJM198209233071321
Weiss, J. M.: Psychosocial factors in stress and disease. Scient Amer, 226: 104-13, 1972. DOI: https://doi.org/10.1038/scientificamerican0672-104
Wilcox, P. M.; Fetting, J. H.; Nettesheim, K. M. & Abeloff, M. D.: Antecipatory vomiting in women receiving cyclophosphamide, methotrexate and 5-FU (CMF) adjuvant chemotherapy for breast carcinoma. Cancer Treat Rep, 66: 1001-3, 1982.
