The Genetic Risk of Cancer Therapy

Authors

  • Eliana Maria Minicucci Faculdade de Medicina. Universidade Estadual Paulista (UNESP). Botucatu (SP), Brasil.
  • Daísy Maria Favero Salvadari Departamento de Patologia. Faculdade de Medicina. Universidade Estadual Paulista (UNESP). Botucatu (SP), Brasil.
  • Lúcia Regina Ribeiro Departamento de Patologia. Faculdade de Medicina. Universidade Estadual Paulista (UNESP). Botucatu (SP), Brasil.
  • Maria Aparecida Conti Maia Hospital A. C. Camargo. São Paulo (SP), Brasil.
  • João Lauro Viana de Camargo Departamento de Patologia. Faculdade de Medicina. Universidade Estadual Paulista (UNESP). Botucatu (SP), Brasil.

DOI:

https://doi.org/10.32635/2176-9745.RBC.2000v46n2.3410

Keywords:

Genetic Risk, Radiotherapy, Brachytherapy, Chemotherapy

Abstract

The presente paper indicates the effects of the most common practices for cancer treatment on the genetic sample of the patient. The main objective of this report is to stress the importance of the risk/benefit assessment of the different therapeutic protocols adopted for cancer and the need for the development of new therapeutic practices and chemotherapy agents. After stressing the fact that cancer is a genetic disease that develops through multiple steps, the effects of ionizing radiation and of some therapeutic Chemicals on the DNA are presented. Besides, the deleterious effects on the DNA of the technical personnel who provides treatment are also indicated. Therefore, this paper discusses tn a general way the genetic damage induced by anti-neoplastic agents, which increases the risk for the development of another primary tumor.

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References

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Published

2022-12-15

How to Cite

1.
Minicucci EM, Salvadari DMF, Ribeiro LR, Maia MAC, Camargo JLV de. The Genetic Risk of Cancer Therapy. Rev. Bras. Cancerol. [Internet]. 2022 Dec. 15 [cited 2024 Jul. 22];46(2):147-54. Available from: https://rbc.inca.gov.br/index.php/revista/article/view/3410

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