A Ceruloplasmina Como Enzima Marcadora de Atividade Neoplásica Maligna
DOI:
https://doi.org/10.32635/2176-9745.RBC.1984v30n3.3460Keywords:
Ceruloplasmin/metabolism, Ceruloplasmin/drug effects, Sarcoma, Experimental/enzymology, Cyclophosphamide/pharmacologyAbstract
Hyperceruloplasminemia was detected in U strain isogenic male rats bearing a syngeneic sarcoma in all phases of neoplasm evolution. Normal levels of ceruloplasmin oxidase activity were only observed after lhe first dose of intraperitoneally administered cyclophosphamide (100 mg/kg). However subsequent weekly therapy with the drug did not prevent the return of high levels of sérum ceruloplasmin in the tumor hosts. Healthy rats treated similarly with cyclophosphamide presented a fall in the enzyme activity after the first dose. The constant hyperceruloplasminemia observed suggests the presence of viable latent sarcoma celles and can serve as a biochemical test to monitorize the malignant process.
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