Planimetria do cone uterino: localização das displasias e neoplasias: um estudo de 23 peças de conização.
DOI:
https://doi.org/10.32635/2176-9745.RBC.1984v30n4.3467Keywords:
Conization, Carcinoma in Situ, Neoplasms, Glandular and EpithelialAbstract
23 specimens from cervical conization were submitted for histological examination and macroscopic and microscopic planimetry. A mapping of all cases was done. A total of 514 sections were studied. From 15 to 28 section (na average of 22,34) were obtained from each specimen. Sections varied from 0,1 to 0,4 cm in thickness. Serial step histological sections were stained by haematoxylin and eosin. Displastic and neoplastic of the squamous epitheliun werw observed.The latter included intraepithelial carcinoma, intraepithelial carcinoma with doubtful stromal invasion, intraepithelial carcinoma with early stromal invasion, microinvasive carcinoma and invasive carcinoma. Lesions were measured and mapped down on the macroscopic drawings. A mathematical conversion index was used to correct distortions due to Processing of the specimens and to secure that the measurements of the histological lesions corresponded, to the greatest possible degree to the ones in the original fresh specimens. Definite different results were obtained with and without the use of the conversion index. Lesions were confined to the external orifice in 10 cases. A predominance in the ectocervix and endocervix was seen in 4 and 5 cases, respectively. Whole endocervix lesions were found in 4 cases. This last finding is remarkable for its rather high incidence.
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ALLEN, A. C. Grading of carcinoma in situ of the cervix. Cancer 17: 979-82, 1964. DOI: https://doi.org/10.1002/1097-0142(196408)17:8<979::AID-CNCR2820170803>3.0.CO;2-D
ANDERSON, M. C. & HARTLEY, R. B. Cervical crypt involvement by intraepithelial neoplasia. Obstet. &Gynecol.55: 546-50, 1980.
BANGLE, R., BERGER, M., LEVIN, M. Vàriations in the morphogenesis of squamous carcinoma of the cervix. Cancer 16: 1151-9, 1963. DOI: https://doi.org/10.1002/1097-0142(196309)16:9<1151::AID-CNCR2820160909>3.0.CO;2-D
BURGHARDT, E. & HOLZER, E. Tretment of carcinoma in situ: evaluation of 1609 cases. Obstet. StGynecol. 5: 539-45, 1980.
CARSON, R. P. & GALL, E. A. Preinvasive carcinoma and precancerous metaplasia of cervix; serial block survey. Am. J. Path. 30; 15-29, 1954.
CASTRO, O. Histotopografia do carcinoma epidermóide do colo uterino. Rev. Bras. de Cancerologia 24 (n° 38) ; 27-46, 1968. DOI: https://doi.org/10.32635/2176-9745.RBC.1968v24n38.4003
CHRISTOPHERSON, W. M. Dysplasia, carcinoma in situ and micro invasive carcinoma of the uterine cervix. Human Pathology 8: 489-501, 1977. DOI: https://doi.org/10.1016/S0046-8177(77)80110-X
CHRISTOPHERSON, W. M., GRAY, L. A. & PARKER, J. E. Microinvasive carcinoma of the uterine cervix. Cancer 38: 629-32, 1976. DOI: https://doi.org/10.1002/1097-0142(197608)38:2<629::AID-CNCR2820380202>3.0.CO;2-E
FENNELL. R. H. Jr. Carcinoma in situ of uterine cervix; report of 118 cases. Cancer 9: 374-84, 1956. DOI: https://doi.org/10.1002/1097-0142(195603/04)9:2<374::AID-CNCR2820090224>3.0.CO;2-P
FENNELL. R. H. Jr. Review: Micro-invasive carcinoma of the uterina cervix. Obstet. Gynocol. Surv. 33: 406-11, 1978. DOI: https://doi.org/10.1097/00006254-197806000-00015
FIDLER, H. K. &BOYES, D. A. Patterns oi early invasion from intra-epithelial carcinoma of the cervix. Cancer 12: 673-80, 1959. DOI: https://doi.org/10.1002/1097-0142(195907/08)12:4<673::AID-CNCR2820120408>3.0.CO;2-0
FOOTE, F. W. Jr. & STEWART, F. W. The anatomical distribution of intraepithelial epidermoid carcinoma of the cervix. Cancer 1 ; 431-40, 1948. DOI: https://doi.org/10.1002/1097-0142(194809)1:3<431::AID-CNCR2820010309>3.0.CO;2-U
FOX, C. H. Biologic behavior of dysplasia and carcinoma in situ. Am. J. Obst. & Gynec. 99: 960-74, 1967. DOI: https://doi.org/10.1016/0002-9378(67)90251-7
GAGNON, F. Contribuition to the study of the etiology and prevention of cancer of the cervix of the uterus. Am. J. Obst. & Gynec. 60: 516-22, 1950. DOI: https://doi.org/10.1016/0002-9378(50)90422-4
HASUMI, K., SAKAMOTO, A. & SUGANO, H. Microinvasive carcinoma of the uterine cervix. Cancer 45: 928-31, 1980. DOI: https://doi.org/10.1002/1097-0142(19800301)45:5<928::AID-CNCR2820450515>3.0.CO;2-3
HASUMI, K., SUGANO, H., SAKAMOTO, G., MASUBUCHI, K., KUBO, H. Circumscribed carcinoma of the uterine cervix, with marked lymphocytic infiitration. Câncer 39; 2503-7, 1977. DOI: https://doi.org/10.1002/1097-0142(197706)39:6<2503::AID-CNCR2820390629>3.0.CO;2-M
HELD, E. intracervicale Lokalisation des nicht invasiven, atypischen Pflasterepitheis (Oberflächencarcinon, carcinoma in situ) und des beginnenden Pflasterzellcarcinoma. Arch. Gynák. 188: 376-90, 1957. DOI: https://doi.org/10.1007/BF00673038
HOLMQUIST, N. D., McMAHAN, C. A., WILLIAMS, D. D. Variability in classification of carcinoma in situ of the uterine cervix. Arch. Path. 84: 334-45, 1967.
HOWARD, L., CYRUS, E., STODDARD, L. D. A study of the incidence and histogenesis of endocervical metaplasia and intraepithelial carcinoma. Observations an 400 uteri removed for noncervical disease. Cancer 4: 1210-23, 1951. DOI: https://doi.org/10.1002/1097-0142(195111)4:6<1210::AID-CNCR2820040607>3.0.CO;2-9
JOHNSON, L. D. The histopathological approach to early cervical neoplasia. Obst. & Gynecol. Surv. 24: 735-67, 1969. DOI: https://doi.org/10.1097/00006254-196907001-00008
JOHNSON, L. D., EASTERDAY, C. L, GORE, H., HERTIG, A. T. Histogenesis of carcinoma in situ of the uterine cervix. A preliminar report of the origin of carcinoma in situ in subcylindrical cell anaplasia. Cancer 17; 213-29, 1964. DOI: https://doi.org/10.1002/1097-0142(196402)17:2<213::AID-CNCR2820170211>3.0.CO;2-V
JOHNSON, L. D., NICKERSON, R. J., EASTERDAY, C. L., STUART, R. S., HERTIG, A. T. Epidemiologic evidence for spectrum of change from dysplasia through carcinoma in situ to invasive cancer. Cancer 22: 901-14, 1968. DOI: https://doi.org/10.1002/1097-0142(196811)22:5<901::AID-CNCR2820220502>3.0.CO;2-J
KONIKOV, N. F., KEMPSON, R. U, PISKIE, V. Cytohistologic correlation of dysplasia, carcinoma in situ and invasive carcinoma of the uterine cervix. Am. J. Clin. Path. 51: 463-69, 1969. DOI: https://doi.org/10.1093/ajcp/51.4.463
KRIEGER, J. S., McCORMACK, L. J. The indications for conservative therapy for intraepithelial carcinoma of the uterine cervix. Am. J. Obst. & Gynec. 76: 312-20, 1958. DOI: https://doi.org/10.1016/0002-9378(58)90219-9
KRIEGER, J. S. & McCORMACK, L. J. Craded treatment for in situ carcinoma of the cervix. Am. J. Obst. & Gynec. 101: 171-82, 1968. DOI: https://doi.org/10.1016/0002-9378(68)90185-3
KRIEGER, J, S., McCORMACK, L. J., BRADLEY, V. F. Role of conization in the detection and treatment of cervical carcinoma in situ. Am. J. Obst. & Gynec. 86: 120-29, 1963. DOI: https://doi.org/10.1016/0002-9378(63)90083-8
LOHE, K. J. Eariy squamous cell carcinoma of the uterine cervix. I. Definition and histology. Gynecologic Oncology 6 : 10-30, 1978. DOI: https://doi.org/10.1016/0090-8258(78)90003-3
LOHE, K. J., BURGHARDT, E., HILLEMANNS, H. G., KAUFMANN C., OBER, K. G., ZANDER, J. Early squamous cell carcinoma of the uterine cervix. II. Clinical results of a Cooperativa Study in the management of 419 patients with early stromal invasion and microcarcinoma. Gynecologic Oncology 6: 31-50, 1978. DOI: https://doi.org/10.1016/0090-8258(78)90004-5
MORICARD, R., CARTIER, R. Topographie orificielle des dystrophies et de l'épithélial du col utérin. Bull. Féd. Soc. Gynéc. et Obst. 8: 314-18, 1956.
MURPHY, W. M., COLEMAN, S. A. The long-term course of carcinoma in situ of the uterine cervix. Cancer 38: 957-63, 1976. DOI: https://doi.org/10.1002/1097-0142(197608)38:2<957::AID-CNCR2820380247>3.0.CO;2-Q
MUSSEY, E., SOULE, E. H., WELCH, J. S. Microinvasive carcinoma of the cervix. Am. J. Obst. Gynecol. 104: 738-44, 1969. DOI: https://doi.org/10.1016/0002-9378(69)90617-6
NG, A. B. P., REAGAN, J. W. Microinvasive carcinoma of the uterine cervix. Am. J. Clin. Path. 52; 511-29, 1969. DOI: https://doi.org/10.1093/ajcp/52.5.511
PETERSEN, O. Spontaneous course of cervical precancerouns condition. Am. J. Obst. Gynecol. 72: 1063-71, 1956. DOI: https://doi.org/10.1016/0002-9378(56)90072-2
POULSEN, H. E., TAYLOR, C. W., SOBIN, L. H. International Histological Classification of Tumors; International Histological Typing of Female Genital Tract Tumors. Geneva, World Health Organization 1975.
PRYZBARA, L. A., PLUTOWA, A. Histological topography of carcinoma in situ of the cervix uteri. Cancer 12: 262-77, 1959. DOI: https://doi.org/10.1002/1097-0142(195903/04)12:2<263::AID-CNCR2820120210>3.0.CO;2-R
PUNO, E. R., AUERBACH, S. H. Preinvasive carcinoma of the cervix uteri. JAMA 131: 960-3, 1946. DOI: https://doi.org/10.1001/jama.1946.02870290010004
REAGAN, J. W., NG, A. B. P., WENTZ, W. B. Concepts of genesis and development in early cervical neoplasia. Obstet. Gynecol. Survey. 24: 860-74, 1969. DOI: https://doi.org/10.1097/00006254-196907001-00016
RICHART, R. M., BARRON, B. A. A follow-up study of patients with cervical dysplasia. Am. J. Obst. & Gynec. 105: 386-93, 1969. DOI: https://doi.org/10.1016/0002-9378(69)90268-3
RICHART, R. M., SCIARRA, J. J. Treatment of cervical dysplasia by out patient electrocauterization. Am. J. Obst. & Gynec. 101: 200-5, 1968. DOI: https://doi.org/10.1016/0002-9378(68)90188-9
RIOTTON, G., CHRISTOPHERSON, W. M., LUNT, R. International Histological Classification of Tumor; Cytology of the female Genital Tract Geneva, World Health Organization, 1973.
ROCHE, W. D., NORRIS, H. J. Microinvasive carcinoma of the cervix. The significance of lymphatic invasion and confluent patterns of stromal growth. Cancer 36: 180-6, 1975. DOI: https://doi.org/10.1002/1097-0142(197507)36:1<180::AID-CNCR2820360116>3.0.CO;2-K
RUBIN, I. C. The pathological diagnosis of incipient carcinoma of the uterus. Am. J. Obst. 62: 668-76, 1910.
RUBIO, C. A., LAGERLOF, B. Autoradiographic studies of dysplasia and carcinoma in situ in cervical cones. Acta Pathol. Microbiol. Scan. (A) 82: 411-18, 1974. DOI: https://doi.org/10.1111/j.1699-0463.1974.tb00366.x
SCHNEPPENHEIM, P., HAMPERL. H., KAUFMANN, C., OBER, K. G. die Beziehungen des Schleimepithels zum Plattenepithel an der Cervix Uteri. cited by HAMPERL, H., KAUFMANN, C. The cervix uteri at diferent ages. Obst. Gynec. 14: 621, 1959. DOI: https://doi.org/10.1007/BF00672656
SCHULMAN, H. CAVANAGH, D. Intraepithelial carcinoma of the cervix. The predictability of residual carcinoma in the uterus from microscopic study of the margins of the cone biopsy specimen. Cancer 14: 795-800, 1961. DOI: https://doi.org/10.1002/1097-0142(199007/08)14:4<795::AID-CNCR2820140415>3.0.CO;2-8
TeLINDE, R. W., GALVIN, G.. The minimal changs in biopsies to justify a diagnosis of cervical cancer. Am. J. Obstet. Gynecol. 48: 774-97, 1944. DOI: https://doi.org/10.1016/S0002-9378(16)40257-7
WHEELER, J. D., HERTIG, A. T. The pathologie anatomy of carcinoma of the uterus. I. Squamous carcinoma of the cervix. Am. J. histological Clin. Path. 25: 345-375, 1955. DOI: https://doi.org/10.1093/ajcp/25.4.345
WILKINSON, E. J., KOMOROWSKl, R. A. Borderline microinvasive carcinoma of the cervix. Obstet. Gynecol. 51; 472-76, 1978. DOI: https://doi.org/10.1097/00006250-197804000-00018
