Estudo Clínico do VM-26 em Associação de Drogas no Tratamento dos Linfomas Malignos, Leucemias e Tumores Sólidos
DOI:
https://doi.org/10.32635/2176-9745.RBC.1977v27n4.3636Keywords:
Teniposide/therapeutic use, Neoplasms/drug therapy, Drug Therapy, CombinationAbstract
Epipophyllotoxin, 4'—demethyl—9—(4, 6-0—2—thenylidene—B—D—Glucopyranoside) VM-26, a new podophyllotoxin derivativa, was given to 26 patients with various types of malignant diseases — lymphoma, monocytoid leukaemia and carcinoma of bladder, breast, colon, jejunum and ovary. The authors found a special usefulness in pleural and peritoneal effusions. The results point to a valid application of V—26 in these conditions and in many cases partial remissions were obtained when other protocols failed. The side effects were gastrointestinal symptoms such as nausea and vomiting; alopecia and leukopenia were negligible.
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References
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