Modalidades Fisioterapéuticas en el Manejo Del Dolor Neuropático Inducido por el Tratamiento del Cáncer de Mama: Revisión de la Literatura
DOI:
https://doi.org/10.32635/2176-9745.RBC.2024v70n1.4392Keywords:
Pain Management/methods, Polyneuropathy, Breast Neoplasms, Antineoplastics/pharmacology, Physical Therapy ModalitiesAbstract
Introduction: Women’s survival after breast cancer treatment has increased due to advances in early detection and available therapies. However, great physical and psychological burden are the result of adverse effects that
survivors commonly face. In addition to fatigue, pain is the most common persistent symptom after cancer treatment. Objective: Systematize the results of randomized clinical trials on physiotherapeutic intervention in peripheral neuropathic pain induced by breast cancer treatments . Method: The search was carried out on the MEDLINE databases via PubMed and Cochrane portals. Randomized clinical trials published since 2017 in English, that addressed physiotherapeutic modalities as intervention,
peripheral neuropathic pain induced by oncological treatments as outcome were selected, and the population of interest were women surviving breast cancer. The Cochrane-risk-of-bias tool was applied to evaluate the
methodological quality of the studies. Results: Four studies were fully reviewed. Most of the adverse effects of cancer treatment are due to taxanebased chemotherapy regimens. The outcomes assessed include, in addition to pain, other neuropathic signs and influence on activities of daily living.
The studies varied in terms of intervention and treatment phase. Only one of the studies demonstrated a significantly positive result in favor of the intervention group. Conclusion: Randomized clinical studies provide scant
evidence regarding the positive effects of physiotherapeutic intervention on
peripheral neuropathic pain induced by breast cancer treatments.
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References
Hauth F, De-Colle C, Weidner N, et al. Quality of life and fatigue before and after radiotherapy in breast cancer patients. Strahlenther Onkol. 2021;197(4):281-7. doi: https://doi.org/10.1007/s00066-020-01700-1 DOI: https://doi.org/10.1007/s00066-020-01700-1
Santos MO, Lima FCS, Martins LFL, et al. Estimativa de incidência de câncer no brasil, 2023-2025. Rev. Bras. Cancerol. 2023;69(1):e-213700. doi: https://doi.org/10.32635/2176-9745.RBC.2023v69n1.3700 DOI: https://doi.org/10.32635/2176-9745.RBC.2023v69n1.3700
Olsson Möller U, Beck I, Rydén L, et al. A comprehensive approach to rehabilitation interventions following breast cancer treatment - a systematic review of systematic reviews. BMC Cancer. 2019;19(1):472. doi: https://doi.org/10.1186%2Fs12885-019-5648-7 DOI: https://doi.org/10.1186/s12885-019-5648-7
Shien T, Iwata H. Adjuvant and neoadjuvant therapy for breast cancer. JPN J Clin Oncol. 2020;50(3):225-9. doi: https://doi.org/10.1093/jjco/hyz213 DOI: https://doi.org/10.1093/jjco/hyz213
Fontes F, Gonçalves M, Pereira S, et al. Neuropathic pain after breast cancer treatment and its impact on sleep quality one year after cancer diagnosis. Breast. 2017;33:125-31 doi https://doi.org/10.1016/j.breast.2017.03.013 DOI: https://doi.org/10.1016/j.breast.2017.03.013
Ilhan E, Chee E, Hush J, et al. The prevalence of neuropathic pain is high after treatment for breast cancer: a systematic review. Pain. 2017;158(11):2082-91. doi: https://doi.org/10.1097/j.pain.0000000000001004 DOI: https://doi.org/10.1097/j.pain.0000000000001004
Leysen L, Adriaenssens N, Nijs J, et al. Chronic pain in breast cancer survivors: nociceptive, neuropathic, or central sensitization pain? Pain Pract. 2019;19(2):1983-5. doi: https://doi.org/10.1111/papr.12732 DOI: https://doi.org/10.1111/papr.12732
Page MJ, McKenzie JE, Bossuyt PM, et al. A declaração PRISMA 2020: diretriz atualizada para relatar revisões sistemáticas. Rev Panam Salud Publica. 2022;46:e112. doi: https://doi.org/10.26633%2FRPSP.2022.112 DOI: https://doi.org/10.26633/RPSP.2022.112
University of York. Centre for Reviews and Dissemination. York: University of York; 2019. PROSPERO - International prospective register of systematic reviews. 2023. [acesso 2023 ago 31]. Disponível em: https://www.crd.york.ac.uk/PROSPERO/
RoB 2: Risk of Bias 2 [Internet]. Versão 5. [Copenhagen]: Cochrane Denmark; 2011. [acesso 2023 mar 9]. Disponível em: https://www.riskofbias.info/
Guijosa A, Freyria A, Espinosa-Fernandez Jr, et al. Pharmacogenetics of taxane-induced neurotoxicity in breast cancer: systematic review and meta-analysis. Clin Transl Sci. 2022;15(10):2403-36. doi: https://doi.org/10.1111%2Fcts.13370 DOI: https://doi.org/10.1111/cts.13370
Hammond EA, Pitz M, Shay B. Neuropathic pain in taxane-induced peripheral neuropathy: evidence for exercise in treatment. Neurorehabil Neural Repair. 2019;33(10):792-9. doi: https://doi.org/10.1177/1545968319860486 DOI: https://doi.org/10.1177/1545968319860486
Zhang YH, Hu HY, Xiong YC, et al. Exercise for neuropathic pain: a systematic review and expert consensus. Front Med (Lausanne). 2021;24(8). doi: https://doi.org/10.3389%2Ffmed.2021.756940 DOI: https://doi.org/10.3389/fmed.2021.756940
Santos FM, Grecco LH, Pereira MG, et al. The neural mobilization technique modulates the expression of endogenous opioids in the periaqueductal gray and improves muscle strength and mobility in rats with neuropathic pain. Behav Brain Funct. 2014;19(19). doi: https://doi.org/10.1186%2F1744-9081-10-19
Dhawan S, Andrews R, Kumar L, et al. A randomized controlled trial to assess the effectiveness of muscle strengthening and balancing exercises on chemotherapyinduced peripheral neuropathic pain and quality of life among cancer patients. Cancer Nurs. 2020;43(4):269-80. doi: https://doi.org/10.1097/ncc.0000000000000693 DOI: https://doi.org/10.1097/NCC.0000000000000693
Ammitzbel G, Andersen KG, Bidstrup PE, et al. Effect of progressive resistance training on persistent pain after axillary dissection in breast cancer: a randomized controlled trial. Breast Cancer Res Treat. 2019;179(1):173-83. doi: https://doi.org/10.1007/s10549-019-05461-z DOI: https://doi.org/10.1007/s10549-019-05461-z
Chimenti RL, Frey-Law LA, Sluka KA. A mechanismbased approach to physical therapist management of pain. Phys Ther. 2018;98(5):302-14. doi: https://doi.org/10.1093%2Fptj%2Fpzy030 DOI: https://doi.org/10.1093/ptj/pzy030
Garcia C, Karri J, Zacharias NA, et al. Use of cryotherapy for managing chronic pain: an evidence-based narrative. Pain Ther. 2021;10(1):81-100. doi: https://doi.org/10.1007%2Fs40122-020-00225-w DOI: https://doi.org/10.1007/s40122-020-00225-w
Griffiths C, Kwon N, Beaumont JL, et al. Cold therapy to prevent paclitaxel-induced peripheral neuropathy. Support Care Cancer. 2018;26:3461-9. doi: https://doi.org/10.1007/s00520-018-4199-9 DOI: https://doi.org/10.1007/s00520-018-4199-9
Izgua N, Metin ZG, Karadas C, et al. “Prevention of chemotherapy-Induced peripheral neuropathy with classical massage in breast cancer patients receiving paclitaxel: an assessor-blinded randomized controlled trial.” Eur. j. oncol. nurs. 2019;40:36-43, doi: https://doi.org/10.1016/j.ejon.2019.03.002 DOI: https://doi.org/10.1016/j.ejon.2019.03.002
Wang Q, Lin J, Yang P, et al. Effect of massage on the tlr4 signalling pathway in rats with neuropathic pain. Pain Res Manag. 2020;2020:8309745. doi: https://doi.org/10.1155%2F2020%2F8309745 DOI: https://doi.org/10.1155/2020/8309745
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