Leiomyosarcoma Metastatic to the Skull and Spine: a Case Report

Abstract

Background: Uterine leiomyosarcomas account for approximately 30% of uterine sarcomas. The peak incidence age is around the mid-thirties reaching a plateau in the mid-fifties. It rarely metastasizes to the skull and the bone. Case Presentation: In this report, we describe an unusual case of uterine leiomyosarcoma metastasizing to both the spine and the skull. This patient had a known diagnosis of uterine leiomyosarcoma following a total hysterectomy five years before. She underwent resection of the skull mass and radiotherapy for the spinal lesions. Conclusion: Leiomyosarcoma is usually accompanied by widespread metastases and a poor chance of survival. Skull metastases are usually seen in the advanced stage of the disease. Surgery cannot change the course of the underlying disease, but can relieve local discomfort. Treatment options for spinal metastases are varied, and definitive statements regarding efficacy cannot be made. To our knowledge, this is the first case of simultaneous metastatic deposits in both spine and skull.