Dialquilnitrosaminas e câncer
DOI:
https://doi.org/10.32635/2176-9745.RBC.1991v37n1/4.3100Palabras clave:
Nitrosaminas, CâncerResumen
Apresenta informações referentes a compostos N-nitroso, particularmente dialquilnitrosaminas, e sua participação na indução de neoplasias experimentais, bem como no homem. Trabalho realizado no Hospital Universitário Antônio Pedro - Niterói - RJ.
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REDDY B5, COHEN LA, McCOY GD, HILL P, WEISBURGER JH, WYNDER EL. Nutrition and its relationship to cancer. Adv Cancer Res 1980; 32: 237-345. DOI: https://doi.org/10.1016/S0065-230X(08)60363-2
WEISBURGER JH, WILLIAMS GM. Etiology of cancer. Chemical carcinogenesis. In: HOLLAND JF, FREI III E. Cancer Medicine. Philadelphia: Lea & Febiger 1982: 42-95. DOI: https://doi.org/10.1007/978-1-4615-6598-7_9
SCHMÂHL D, OSSWALD H. Carcinogenesis in different animals species by diethylnitrosamine. Experientia 1967; 23: 497-498. DOI: https://doi.org/10.1007/BF02142199
WOGAN G. The induction of liver cell cancer by chemicals. In: CAMERON HM, LINSELL DA, WARWICK GP eds. Liver Cell Cancer. Amsterdam: Elsevier 1976: 121-152. DOI: https://doi.org/10.1016/B978-0-444-41542-4.50011-0
IARC-WHO. N-nitrosodiethylamine. IARC monographs on the evaluation of the carcinogenic risk of chemicais to humans 1978; (17): 83-124. DOI: https://doi.org/10.1016/0013-9351(78)90068-3
MARGISON GP, O'CONNOR PJ. Nucleic acid modification by N-nitroso compounds. in: GROVER PL, ed. Chemical Carcinogens and DNA. Vol 1, 2nd ed., Boca Raton, Florida: CRC Press 1980: 111-159.
UDASHIMA S. Overview: N-nitroso compounds as carcinogens for experimental animais and man. Oncology 1980; 37: 282-286. DOI: https://doi.org/10.1159/000225453
PURCHASE 1 FH. Inter-species comparisons ofcarcinogenicity. Br J Cancer 1980; 41: 454-A68. DOI: https://doi.org/10.1038/bjc.1980.70
DE PAOLA D. Câncer e MeioAmbiente. Rio de Janeiro: Medsi 1985: 54.
LIJINSKY W. Species diferences in nitrosamine carcinogenesis. J Cancer Res Clin Oncol 1984; 108: 46-55. DOI: https://doi.org/10.1007/BF00390972
CULVENOR CCJ, JAGO MV. Carcinogenic plant products and DNA. in: GROVER PL ed. Chemical Carcinogens and DNA. Vol 1, 2nd ed. Boca Raton. Florida: CRC Press 1980: 161-186.
Mc CORMICK A, NICHOLSON MJ, BAYLIS MA, UNDERWOOD JG. Nitrosamine in cigarette smoke condensate. Nature 1973; 244: 237-38. DOI: https://doi.org/10.1038/244237a0
SELKIRK JK. Chemical carcinogenesis: a brief overview of the mechanism of action of polycyclic hydrocarbons, aromatic amines, nitrosamines, and aflatoxins. in: SLAGA TJ ed. Modifiers of Chemical Carcinogenesis. NewYork: Raven Press 1980:1-31.
WEISBURGER EK. Metabolism and activation of chemical carcinogens. Molec Cell Biochem 1980; 32:95-104. DOI: https://doi.org/10.1007/BF00227802
MIRVISH SS, BULAY O, RUNGE R, PATIL K. Study of the carcinogenicity of large doses of dimethylnitramine, N-nitroso-L-proline, and sodium nitrite administered in drinking water to rates. JNCI 1980; 64: 1435- 1442. DOI: https://doi.org/10.1093/jnci/64.6.1435
FlNE DH, ROSS A, ROUNBEHLER DP, SILVERGLEID A, SONG L. Formation in vivo of volatile N-nitrosamines in man after ingestion of cooked bacon and spinach. Nature 1977; 265: 753-75. DOI: https://doi.org/10.1038/265753a0
ZEISEL SH, DA COSTA K. Increase in human exposure to methylamine precursors of N-nitrosamines after eating fish. Cancer Res 1986; 46: 6136-138.
HEATH DF. The decomposition and toxicity of dialkylnitrosamines in rats. Biochem J 1962; 85: 72-91. DOI: https://doi.org/10.1042/bj0850072
BRITEBBO EB, LFBERG B, TJÂLVE H. Sites of metabolism of N-nitrosodiethylamine in mice. Chem-Biol lnteract 1981; 34:209-221. DOI: https://doi.org/10.1016/0009-2797(81)90132-0
MAGEE PN, FARBER E. Toxic liver injury and carcinogenesis. Methylation of rat-liver nucleic acids by dimethylnitrosamine in vivo. BiochemJ 1962; 83: 114-124. DOI: https://doi.org/10.1042/bj0830114
MAGEE PN, HULTIN T. Toxic liver injury and carcinogenesis. Methylation of proteins of rat-liver slices by dimethylnitrosamine in vitro. Biochem J 1962; 83: 106-114. DOI: https://doi.org/10.1042/bj0830106
MAGEE PN, LEE KY. Ceilular injury and carcinogenesis. Alkylation of ribonucieic acid of rat liver by diethylnitrosamine and n-butylmethylnitrosamine in vivo. Biochem J 1964; 91:35-42. DOI: https://doi.org/10.1042/bj0910035
SWANN PF, MAGEE PN. Nitrosamine-induced carcinogenesis. The alkylation of N-7 of guanine of nucieic acids of the rat by dieth-ylnitrosamine, N-ethyl-N-nitrosoureaand ethyI-mthanesulphonate. BiochemJ 1971; 125: 841-847. DOI: https://doi.org/10.1042/bj1250841
CRADDOCK VM. Ceil proliferation and experimental liver cancer. IN: CAMERON HM, LINSELL DA, WARWICK GP, eds. Liver Cell Cancer. Amsterdam: Elsevier 1976: 153-201. DOI: https://doi.org/10.1016/B978-0-444-41542-4.50012-2
WILLIAMS GM. The pathogenesis of rat liver cancer caused by chemical carcinogens. Biochem Biophys Acta 1980; 605: 167-189. DOI: https://doi.org/10.1016/0304-419X(80)90003-7
RABES HM. Deveiopment and growth of early preneoplastic lesions induced in the liver by chemical carcinogens. J Cancer Res Clin Oncol 1983; 106: 85-92. DOI: https://doi.org/10.1007/BF00395384
PARTHASARATHY R, FRIDEY SM. Conformation of 06-alkyiguariosides: molecular mechanism of mutagenesis. Carcinogenesis 1986: 7: 221-227. DOI: https://doi.org/10.1093/carcin/7.2.221
FUNATO T, YOKOTA J, SAKAMOTO H et aI. Activation of N-ras gene in a rat hepatoceilular carcinoma induced by dibutylnitrosamine and butylated hudroxytoluene. Jpn J Cancer Res (Gann) 1987; 78: 689-94.
FARBER E. The pathology of experimental liver cell cancer. In: CAMERON HM, LINSELL DA, WARWICK GP eds. Livor Cell Cancer. Amsterdam: Elsevier 1976: 243-277. DOI: https://doi.org/10.1016/B978-0-444-41542-4.50014-6
RABES H, HARTENSTEIN R, SCHOLZE P. Specific stages of celular response to homeostatic control during diethylnitrosamine-induced liver carcinogenesis. Experientia 1970: 26: 1356-1359. DOI: https://doi.org/10.1007/BF02113030
PITOT HC. The natural history of neoplasia. Newer insights into na old problem. Am J Pathol 1977:89: 402-411.
SOLT D, FARBER E. New principie for the analysis of chemical carcinogenesis. Nature 1976: 263: 701-703. DOI: https://doi.org/10.1038/263701a0
KOEN H, PUGH TD, GOLDFARB S. Hepatocarcinogenesis in the mouse. Combined morphologic stereologic studies. Am J Pathol 1983: 112: 89-100.
PERAINO C, CARNES BA, STEVENS FJ. Evidence for growth heterogeneity among foci with different phenotypes in the population of altered hepatocyte foci induced by a single neonatal treatment with carcinogen. Carcinogenesis 1986: 7: 191-192. DOI: https://doi.org/10.1093/carcin/7.2.191
ARGUS MF, HOCH-LIGETI C. Induction of malignant tumors in the guinea pig by oral administration of diethylnitrosamine. JNCI 1963; 30: 533-551.
HERROLD KM, DUNHAM U. Induction of tumors in the syrian hamster with diethylnitrosamirie (N-nitrosodiethylamine). Cancer Res 1963: 23: 773-777.
THOMAS C, SCHMÃHL D. The morphology of diethylnitrosamine induced hepatic tumors in the mouse guinea pig. Z Krebsforsch 1963; 65: 531-536. DOI: https://doi.org/10.1007/BF00525227
TAKAYAMA 5, OOTA K. Induction of malignant tumors in various strains of mico by oral administration of N-nitrosodimethylamine and N-nitrosodiethylamine. GAN N 1965: 56: 189-199.
MOHR U, ALTHOFF J, AUTHALER A. Diaplacental effect of the carcinogen diethylnitrosamine in the golden hamster. Cancer Res 1966: 26: 2349-2352.
REUBER MD, LEE CW. Effect of age and sex on hepatic lesions in Buffalo strain rats ingesting diethylnitrosamine. JNCI 1968; 41: 1133-1140.
CLAPP NK. Carcinogenicity of nitrosamines and methanesulphonate esters given intraperitoneally, in AF mico. Int J Cancer 1973: 12: 728-733. DOI: https://doi.org/10.1002/ijc.2910120320
AKAMATSU Y. Carcinogenicity of N-nitrosodiethylamine (DEN), N-nitrosodi-N-butylamine (DBN), and N-methyl-N-nitro-N-nitrosoguanidine (MNG) in strains of mico: single intragastric treatment of 10 times maximum tolerated dose (MTD). Proc Amor Ass Cancer Res 1975; 16:162.
HAAS H, KMOCH N, MOHR U. Susceptibility of gerbils (Meriones unguiculatus) to weekly subcutaneous and single intravenous injections of N-diethylnitrosamine. Z Krebsforsch 1975: 83: 233-238. DOI: https://doi.org/10.1007/BF00304093
DIWAN BA, MEIER H. Carcinogenic effects of a single dose 01 diethylnitrosamine in three unrelated strains of mice: genetc dependence of the induced tumor types and incidence. Cancer Lett 1976; 1: 249- 253. DOI: https://doi.org/10.1016/S0304-3835(75)97372-3
UCHIDA E, HIRONO 1. Effect of phenobarbital on induction of liver and lung tumors by dimethylnitrosamine in newborn mice. GANN 1979; 70: 639-644.
CRAMPTON RF. Carcinogenic dose-related response to nitrosamines. Oncology 1980; 37:251-254. DOI: https://doi.org/10.1159/000225446
VESSELINOVITCH SD, KOKA M, MIHAILOVICH N, RAO KVN. Carcinogenicity 01 diethylnitrosamine in newborn, inlant, and adult mice. J Cancer Res Clin Oncol 1984; 108: 60-65. DOI: https://doi.org/10.1007/BF00390974
DIWAN BA, RICE JM, OHSHIMA M, WARD JM. lnterstrain differences in susceptibility to liver carcinogenosis initiated by N-nitrosodiethylamirie and its promotion by phenobarbital in C5781/6NCr, C31-1/HeNCrlv and DBAJ2NCr. Carcinogenesis 1986; 7: 215-220. DOI: https://doi.org/10.1093/carcin/7.2.215
TSUDA H, MERAY, SEKI K, AOKI T, FUKUSHIMAS, ITO N. lnduction of tumors in the liver, urinary bladder, esophagus and forestomach by short-term treatment with different doses 01 N,N'dibutylnitrosamine in rats. Jpri J Cancer Res (Gann) 1987; 78: 227-234.
THOMAS C. Zur morphologie der durch Diâthylnitrosamin erzeugten Leberverânderungen und Tumoren bel der Ratte. Z Krebsforsch 1961 :64: 224-233. DOI: https://doi.org/10.1007/BF00525135
SVOBODA D, HIGGINJSON J. A comparison 01 ultrastructural changes in rat liver dueto chemical carcinogens. Cancer Res 1968; 28: 1703-1733.
WEISBURGER JH, MADISON RM, WARD JM, VIGUERA C, WEISBU ROER EK. Modification 01 diethylnitrosamine liver carcinogenesis with phenobarbital but not with immunosuppression. JNCI 1975; 54: 1185-1188. DOI: https://doi.org/10.1093/jnci/54.5.1185
MOCHIZUKI Y, FURUKAWA K, SAWADA N, GOTOH M. Dosedependent enhancing effect of phenobarbital on hepatocarcinogenesis initiated by diethylnitrosamine in the rat. GANN 1981; 72: 170- 173.
KITAGAWA T, SUGANO H. Enhancing effect cl phenobarbital on the development 01 enzymeltered islands and hepatoceliular carcinomas initiated by 3'-methyl-4-(dimethylamino)azobenzene or diethylnitrosamine. GANN 1978; 69: 679-687.
NISF-IIZUMI M. Etfect of phenobarbital, dichlorodiphenyltrichloroethar,e, and polychlorinated biphenyls on diethylnitrosamine-induced hepatocarcinogenesis. GANN 1979; 70: 835-837.
WILLIAMS GM, FURUYA K. Distinction between liver nooplasm promoting and syncarcinogenic effects demonstrated by exposure to phenobarbital or diethylnitrosamine either before or alter N-2-fluo-renylacetamide. Carcinogenesis 1984; 5: 171-174. DOI: https://doi.org/10.1093/carcin/5.2.171
Mc LEAN AEM, SMITH M, DRIVER HE. Liver tumours alter single dose dimethylnitrosamine, low and high protein diet, and phenobarbitone. Carcinogenesis 1982: 3: 701-709. DOI: https://doi.org/10.1093/carcin/3.6.707
SCHMÂHL D, THOMAS C, KÕNIG K. Versuche zur Krebserzeugung mit Diâthylnitrosamin by Mausori. Naturwissechaften 1963; 50: 407. DOI: https://doi.org/10.1007/BF01178611
KUNZ W, SCHAUDE G, THOMAS C. The effect cl fenobarbital and halogenated hydrocarboris on nitrosamine carcinogenesis. Z Krebsforsch 1969; 72: 291-304. DOI: https://doi.org/10.1007/BF00524342
GARGUS JL, PAYNTER OE, REESE Jr WH. Utilization of newborn mice in the bioassay of chemical carcinogens. Toxicol Appl Pharmacol 1969; 15: 552-559. DOI: https://doi.org/10.1016/0041-008X(69)90057-X
PEREIRA MA, KLAUNIG JE, HERREN-FREUND SL, RUCH RJ. Effect of phenobarbital on the development cl liver tumors in juvenile and adult mice. JNCI 1986; 77:449-452.
VESSELINOVITCH SD. lnfant mouse as a sensitive biossay system for carcinogenicity of N-nitroso compounds. IARC Sci Pubi 1980; (31): 645-655.
WARD JM, AlCE JM, CREASIA D, LYNCH P, RIGGS C. Dissimilar patterns cl promotion by di(2-ethyhexyl) phtalate and fenobarbital of hepatoceliular neoplasia initiated by diothylnitrosamine in B6C3F mice. Carcinogenesis 1983; 4: 1021-1029. DOI: https://doi.org/10.1093/carcin/4.8.1021
CARDESA A, POUR P, HAAS H, ALTHOFF J, MOHR U. Histogenesis cl tumors from the nasal cavities induced by diethylnitrosamine. Cancer 1976; 37: 346-355. DOI: https://doi.org/10.1002/1097-0142(197601)37:1<346::AID-CNCR2820370145>3.0.CO;2-#
GREEN U, KETKAR M. The influence cl diazepam and thiouracil upon the carcinogenic effect of diethylnitrosamino in gerbils. Z Krebsforsch 1978; 92: 55-62. DOI: https://doi.org/10.1007/BF00284094
