Experimental Chemical Carcinogenesis in the Salivary Glands - a Literature Review

Abstract

Objective: The most frequent neoplasms in experimental carcinogenesis of the salivary glands in animals are carcinomas and sarcomas, whether alone or in association. The diagnosis of carcinosarcoma has only been mentioned in more recent research. Literature review: 7,12-dimethylbenz[a]anthracene is the most common carcinogenic substance used in laboratory animals. This compound belongs to the polycyclic aromatic hydrocarbon group and is reported as the substance of choice in salivary gland experimental oncogenesis. Material and Methods: A literature review was performed to evaluate the data on animals suitable for carcinogenesis, carcinogen concentration, and tumor development related to salivary glands. Discussion and conclusion: The results showed both a lack of consensus among the authors and the need for standardization of the classification and nomenclature of DMBA induced glandular neoplasms.