Revisão e atualização sobre carcinogênese química cutânea
DOI:
https://doi.org/10.32635/2176-9745.RBC.1995v41n2.2933Palavras-chave:
Carcinogênese, Iniciação, Promoção, PeleResumo
A pele de camundongo tem uma longa história como modelo experimental vantajoso no estudo da carcinogênese. As informações adquiridas através da indução química de tumores cutâneos indicam que o desenvolvimento neoplásico consiste de múltiplas etapas. As pesquisas mais recentes têm elucidado alguns dos eventos moleculares e celulares essenciais nas etapas de iniciação, promoção e progressão. Este artigo descreve os conceitos atuais sobre carcinogênese química cutânea multifásica e os mecanismos biológicos relacionados à iniciação tumoral.
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